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Sponges from North Borneo and their bioactivity against human colorectal cancer cells

Sponges are major source of numerous cytotoxic compounds that are used for defence as well as adaptation to the environment. Numerous studies have discovered compounds from sponge extracts that were effective against a wide range of cancer cells. In this study, a total of 23 sponges comprising of 19...

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Main Authors: Yoong, Soon Yong, Swee, Cheng Lim, Lee, Ping Chin, Yee, Soon Ling
Format: Article
Language:English
English
Published: Borneo Marine Research Institute 2018
Subjects:
SH Aquaculture. Fisheries. Angling
Online Access:https://eprints.ums.edu.my/id/eprint/21865/1/Sponges%20from%20North%20Borneo%20and%20their%20bioactivity%20against%20human%20colorectal%20cancer%20cells.pdf
https://eprints.ums.edu.my/id/eprint/21865/7/Sponges%20from%20North%20Borneo%20and%20their%20bioactivity%20against%20human%20colorectal%20cancer%20cells.pdf
https://eprints.ums.edu.my/id/eprint/21865/
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spelling my.ums.eprints.218652023-06-07T00:45:37Z https://eprints.ums.edu.my/id/eprint/21865/ Sponges from North Borneo and their bioactivity against human colorectal cancer cells Yoong, Soon Yong Swee, Cheng Lim Lee, Ping Chin Yee, Soon Ling SH Aquaculture. Fisheries. Angling Sponges are major source of numerous cytotoxic compounds that are used for defence as well as adaptation to the environment. Numerous studies have discovered compounds from sponge extracts that were effective against a wide range of cancer cells. In this study, a total of 23 sponges comprising of 19 species were collected from Northeast Borneo. Sponges were treated and extracted using modified Folch extraction method, followed by cytotoxicity assay to determine their effectiveness against different colorectal cancer cells. Our results demonstrate that Monanchora clathrata, Dysidea sp., and Jaspis sp. possess different degrees of cytotoxicity against a wide range of human colorectal cancer cells. Monanchora clathrata (KDT07), Dysidea sp. (KDT09), and Jaspis sp. (KDT18) are among the demosponges which possess significant cytotoxicity against colorectal cancer cell lines, including HCT116, LoVo, SW480, and SW620. KDT08 and KDT21 which fall under the same genus Dysidea, possess insignificant cytotoxicity against colorectal cancer cells suggested environmental factors (symbiotic organisms) play a role in biosynthesizing bioactive compounds. Presented results suggested the importance of intensifying research on isolating and purifying natural products from marine sponges for useful applications. Borneo Marine Research Institute 2018-12 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/21865/1/Sponges%20from%20North%20Borneo%20and%20their%20bioactivity%20against%20human%20colorectal%20cancer%20cells.pdf text en https://eprints.ums.edu.my/id/eprint/21865/7/Sponges%20from%20North%20Borneo%20and%20their%20bioactivity%20against%20human%20colorectal%20cancer%20cells.pdf Yoong, Soon Yong and Swee, Cheng Lim and Lee, Ping Chin and Yee, Soon Ling (2018) Sponges from North Borneo and their bioactivity against human colorectal cancer cells. Borneo Journal of Marine Science and Aquaculture, 2. pp. 40-47. ISSN 2600-8637
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic SH Aquaculture. Fisheries. Angling
spellingShingle SH Aquaculture. Fisheries. Angling
Yoong, Soon Yong
Swee, Cheng Lim
Lee, Ping Chin
Yee, Soon Ling
Sponges from North Borneo and their bioactivity against human colorectal cancer cells
description Sponges are major source of numerous cytotoxic compounds that are used for defence as well as adaptation to the environment. Numerous studies have discovered compounds from sponge extracts that were effective against a wide range of cancer cells. In this study, a total of 23 sponges comprising of 19 species were collected from Northeast Borneo. Sponges were treated and extracted using modified Folch extraction method, followed by cytotoxicity assay to determine their effectiveness against different colorectal cancer cells. Our results demonstrate that Monanchora clathrata, Dysidea sp., and Jaspis sp. possess different degrees of cytotoxicity against a wide range of human colorectal cancer cells. Monanchora clathrata (KDT07), Dysidea sp. (KDT09), and Jaspis sp. (KDT18) are among the demosponges which possess significant cytotoxicity against colorectal cancer cell lines, including HCT116, LoVo, SW480, and SW620. KDT08 and KDT21 which fall under the same genus Dysidea, possess insignificant cytotoxicity against colorectal cancer cells suggested environmental factors (symbiotic organisms) play a role in biosynthesizing bioactive compounds. Presented results suggested the importance of intensifying research on isolating and purifying natural products from marine sponges for useful applications.
format Article
author Yoong, Soon Yong
Swee, Cheng Lim
Lee, Ping Chin
Yee, Soon Ling
author_facet Yoong, Soon Yong
Swee, Cheng Lim
Lee, Ping Chin
Yee, Soon Ling
author_sort Yoong, Soon Yong
title Sponges from North Borneo and their bioactivity against human colorectal cancer cells
title_short Sponges from North Borneo and their bioactivity against human colorectal cancer cells
title_full Sponges from North Borneo and their bioactivity against human colorectal cancer cells
title_fullStr Sponges from North Borneo and their bioactivity against human colorectal cancer cells
title_full_unstemmed Sponges from North Borneo and their bioactivity against human colorectal cancer cells
title_sort sponges from north borneo and their bioactivity against human colorectal cancer cells
publisher Borneo Marine Research Institute
publishDate 2018
url https://eprints.ums.edu.my/id/eprint/21865/1/Sponges%20from%20North%20Borneo%20and%20their%20bioactivity%20against%20human%20colorectal%20cancer%20cells.pdf
https://eprints.ums.edu.my/id/eprint/21865/7/Sponges%20from%20North%20Borneo%20and%20their%20bioactivity%20against%20human%20colorectal%20cancer%20cells.pdf
https://eprints.ums.edu.my/id/eprint/21865/
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score 13.211869

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