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Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines

The exponentially growing human population and the emergence of new diseases are clear indications that the world can no longer depend solely on conventional vaccine technologies and production schemes. The race to find a new vaccine technology is crucial to help speed up and complement the World He...

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Main Authors: Clarence M. Ongkudon, Jerry Ho, Michael K. Danquah
Format: Article
Language:English
Published: Taylor & Francis 2011
Subjects:
QR Microbiology
Online Access:https://eprints.ums.edu.my/id/eprint/20570/1/Mitigating%20the%20Looming%20Vaccine%20crisis.pdf
https://eprints.ums.edu.my/id/eprint/20570/
https://doi.org/10.3109/07388551.2010.483460
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spelling my.ums.eprints.205702018-08-07T07:12:47Z https://eprints.ums.edu.my/id/eprint/20570/ Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines Clarence M. Ongkudon Jerry Ho Michael K. Danquah QR Microbiology The exponentially growing human population and the emergence of new diseases are clear indications that the world can no longer depend solely on conventional vaccine technologies and production schemes. The race to find a new vaccine technology is crucial to help speed up and complement the World Health Organization (WHO) disease elimination program. The ultimate goal is to uncover fast and efficient production schemes in the event of a pandemic, and also to effectively fight deadly diseases such as malaria, bird flu, hepatitis, and human immunodeficiency virus (HIV). Plasmid DNA vaccines, if properly formulated, offer specific priming of the immune system and similar or even better prophylactic effects than conventional vaccines. This article discusses many of the critical issues that need to be considered when developing fast, effective, and reliable plasmid DNA vaccine manufacturing processes. Different modes of plasmid production via bacterial fermentation are compared. Plasmid purification by chromatography is specifically discussed as it is the most commercially viable bioprocess engineering technique for continuous purification of supercoiled plasmid DNA. Current techniques and progress covering the area of plasmid DNA vaccine design, formulation, and delivery are also put forward. Taylor & Francis 2011 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/20570/1/Mitigating%20the%20Looming%20Vaccine%20crisis.pdf Clarence M. Ongkudon and Jerry Ho and Michael K. Danquah (2011) Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines. Critical Reviews in Biotechnology. pp. 32-52. ISSN 0738-8551 https://doi.org/10.3109/07388551.2010.483460
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic QR Microbiology
spellingShingle QR Microbiology
Clarence M. Ongkudon
Jerry Ho
Michael K. Danquah
Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines
description The exponentially growing human population and the emergence of new diseases are clear indications that the world can no longer depend solely on conventional vaccine technologies and production schemes. The race to find a new vaccine technology is crucial to help speed up and complement the World Health Organization (WHO) disease elimination program. The ultimate goal is to uncover fast and efficient production schemes in the event of a pandemic, and also to effectively fight deadly diseases such as malaria, bird flu, hepatitis, and human immunodeficiency virus (HIV). Plasmid DNA vaccines, if properly formulated, offer specific priming of the immune system and similar or even better prophylactic effects than conventional vaccines. This article discusses many of the critical issues that need to be considered when developing fast, effective, and reliable plasmid DNA vaccine manufacturing processes. Different modes of plasmid production via bacterial fermentation are compared. Plasmid purification by chromatography is specifically discussed as it is the most commercially viable bioprocess engineering technique for continuous purification of supercoiled plasmid DNA. Current techniques and progress covering the area of plasmid DNA vaccine design, formulation, and delivery are also put forward.
format Article
author Clarence M. Ongkudon
Jerry Ho
Michael K. Danquah
author_facet Clarence M. Ongkudon
Jerry Ho
Michael K. Danquah
author_sort Clarence M. Ongkudon
title Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines
title_short Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines
title_full Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines
title_fullStr Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines
title_full_unstemmed Mitigating the Looming Vaccine crisis: production and delivery of Plasmid-Based Vaccines
title_sort mitigating the looming vaccine crisis: production and delivery of plasmid-based vaccines
publisher Taylor & Francis
publishDate 2011
url https://eprints.ums.edu.my/id/eprint/20570/1/Mitigating%20the%20Looming%20Vaccine%20crisis.pdf
https://eprints.ums.edu.my/id/eprint/20570/
https://doi.org/10.3109/07388551.2010.483460
_version_ 1760229732815732736
score 13.211869

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