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Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity

This work aims to shed light in the fabrication of poly(3-hydroxybutyrate-co-44%-4-hydroxybutyrate)[P(3HB-co-44%4HB)]/chitosan-based silver nanocomposite material using different contents of silver nanoparticle (SNP); 1-9 wt%. Two approaches were applied in the fabrication; namely solvent casting an...

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Main Authors: Rennukka M, Coswald Stephen Sipaut @ Mohd Nasri, Amirul AA
Format: Article
Language:English
Published: American Institute of Chemical Engineers 2014
Subjects:
TP Chemical technology
Online Access:https://eprints.ums.edu.my/id/eprint/20282/1/Synthesis%20of%20poly.pdf
https://eprints.ums.edu.my/id/eprint/20282/
https://doi.org/10.1002/btpr.1986
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spelling my.ums.eprints.202822018-06-13T00:24:32Z https://eprints.ums.edu.my/id/eprint/20282/ Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity Rennukka M Coswald Stephen Sipaut @ Mohd Nasri Amirul AA TP Chemical technology This work aims to shed light in the fabrication of poly(3-hydroxybutyrate-co-44%-4-hydroxybutyrate)[P(3HB-co-44%4HB)]/chitosan-based silver nanocomposite material using different contents of silver nanoparticle (SNP); 1-9 wt%. Two approaches were applied in the fabrication; namely solvent casting and chemical crosslinking via glutaraldehyde (GA). A detailed characterization was conducted in order to yield information regarding the nanocomposite material. X-ray diffraction analysis exhibited the nature of the three components that exist in the nanocomposite films: P(3HB-co-4HB), chitosan, and SNP. In term of mechanical properties, tensile strength, and elongation at break were significantly improved up to 125% and 22%, respectively with the impregnation of the SNP. The melting temperature of the nanocomposite materials was increased whereas their thermal stability was slightly changed. Scanning electron microscopy images revealed that incorporation of 9 wt% of SNP caused agglomeration but the surface roughness of the material was significantly improved with the loading. Staphylococcus aureus and Escherichia coli were completely inhibited by the nanocomposite films with 7 and 9 wt% of SNP, respectively. On the other hand, degradation of the nanocomposite materials outweighed the degradation of the pure copolymer. These bioactive and biodegradable materials stand a good chance to serve the vast need of biomedical applications namely management and care of wound as wound dressing. American Institute of Chemical Engineers 2014 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/20282/1/Synthesis%20of%20poly.pdf Rennukka M and Coswald Stephen Sipaut @ Mohd Nasri and Amirul AA (2014) Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity. Biotechnology Progress, 30 (6). ISSN 1520-6033 https://doi.org/10.1002/btpr.1986
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Rennukka M
Coswald Stephen Sipaut @ Mohd Nasri
Amirul AA
Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity
description This work aims to shed light in the fabrication of poly(3-hydroxybutyrate-co-44%-4-hydroxybutyrate)[P(3HB-co-44%4HB)]/chitosan-based silver nanocomposite material using different contents of silver nanoparticle (SNP); 1-9 wt%. Two approaches were applied in the fabrication; namely solvent casting and chemical crosslinking via glutaraldehyde (GA). A detailed characterization was conducted in order to yield information regarding the nanocomposite material. X-ray diffraction analysis exhibited the nature of the three components that exist in the nanocomposite films: P(3HB-co-4HB), chitosan, and SNP. In term of mechanical properties, tensile strength, and elongation at break were significantly improved up to 125% and 22%, respectively with the impregnation of the SNP. The melting temperature of the nanocomposite materials was increased whereas their thermal stability was slightly changed. Scanning electron microscopy images revealed that incorporation of 9 wt% of SNP caused agglomeration but the surface roughness of the material was significantly improved with the loading. Staphylococcus aureus and Escherichia coli were completely inhibited by the nanocomposite films with 7 and 9 wt% of SNP, respectively. On the other hand, degradation of the nanocomposite materials outweighed the degradation of the pure copolymer. These bioactive and biodegradable materials stand a good chance to serve the vast need of biomedical applications namely management and care of wound as wound dressing.
format Article
author Rennukka M
Coswald Stephen Sipaut @ Mohd Nasri
Amirul AA
author_facet Rennukka M
Coswald Stephen Sipaut @ Mohd Nasri
Amirul AA
author_sort Rennukka M
title Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity
title_short Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity
title_full Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity
title_fullStr Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity
title_full_unstemmed Synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity
title_sort synthesis of poly (3-hydroxybutyrate-co-4 hydroxybutyrate)/chitosan/silver nanocomposite material with enhanced antimicrobial activity
publisher American Institute of Chemical Engineers
publishDate 2014
url https://eprints.ums.edu.my/id/eprint/20282/1/Synthesis%20of%20poly.pdf
https://eprints.ums.edu.my/id/eprint/20282/
https://doi.org/10.1002/btpr.1986
_version_ 1760229694043586560
score 13.211869

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