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Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers

Most vegetable farmers are using agricultural chemicals on their farms. Many of these chemicals are used to control pests and are known as pesticides. Pesticides can be considered according to their chemical basis. Most of the more toxic pesticides fall into chemical groups of organophosphates, carb...

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Main Authors: Shamsul Bahari Shamsudin, Hang Yap T
Format: Article
Language:English
Published: 2011
Subjects:
HD Industries. Land use. Labor
Online Access:https://eprints.ums.edu.my/id/eprint/19686/1/Occupational%20exposure%20of%20pesticides%20on%20activities%20of%20Alanine%20aminotransferase.pdf
https://eprints.ums.edu.my/id/eprint/19686/
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spelling my.ums.eprints.196862018-04-02T06:16:30Z https://eprints.ums.edu.my/id/eprint/19686/ Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers Shamsul Bahari Shamsudin Hang Yap T HD Industries. Land use. Labor Most vegetable farmers are using agricultural chemicals on their farms. Many of these chemicals are used to control pests and are known as pesticides. Pesticides can be considered according to their chemical basis. Most of the more toxic pesticides fall into chemical groups of organophosphates, carbamates and bipyridyls. Approach: The general objective to study the level of liver enzymes as a result of being exposed to pesticides among the farmers in Muar, Johor. The specific objectives of the study are to identified relationship between pesticides exposure durations with the liver enzyme level, frequency handling the pesticides and using PPE when application the pesticides, compare the liver enzyme level between exposure group and comparative group and finally identified the factor which can influence the liver enzyme lever at farmer who exposed to pesticides. The cross sectional study on the effect of pesticides to the liver enzymes among farmer at Muar Johor was conducted by using the liver enzymes such as Alanine Aminotransferase (ALAT) and g-Glutamyltranspeptidase (GGT) as indicators. 92 workers were selected as respondents, where 47 respondents are in the exposed group and the other 45 respondents in the comparative group. Respondents had been selected from farmers in Muar as the exposed group and respondents who from Terengganu Health District Office as the comparative group. The selection of the respondents was made through purposive sampling from list provided. The liver enzymes level was measured by taking blood from respondent. The Automatic Analyzer Hitachi 902 was used in the blood analysis. Two types of the liver enzymes (ALAT and GGT) were analyzed. Results: Mean GGT for exposed group was 63.5 Units/L and ALAT was 61.9 Units/L, significantly higher compare to comparative group while the mean of GGT was 20.7 Units/L and ALAT was 23 Units/L. Non-parametric difference Mann-Whitney U test showed there was significant different between exposed and comparative group on GGT (Z = -6.535; p£0.001) and ALAT level (Z = -5.315; p£0.001). Five occupational factors have been measured in this study which is years of working, number of pesticide used per day, frequency of handling pesticide per day, pesticide spraying durations and Personal Protective Equipment (PPE) scores. Result showed both GGT and ALAT enzymes level has significant correlations with pesticide spraying durations (r = 412; p = 0.004 and r = 0.445; p = 0.002) and Personal Protective Equipment(PPE) scores (r = -0.397; p = 0.006 and r = -0.478; p = 0.001). Pesticides spraying durations was the occupational exposure factoring which most influence GGT (b = 0.710; p<0.001) and ALAT (b = 0.574; p<0.001) enzymes level among exposed group after adjustments for all confounders in this study. Conclusion: After adjustments of the confounding factors, result shows that frequency of handling pesticide per day and pesticide spraying duration (hours) influence the enzyme GGT level among exposed workers, meanwhile years of working and pesticide spraying duration (hours) influence the enzyme ALAT level among exposed workers. 2011 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/19686/1/Occupational%20exposure%20of%20pesticides%20on%20activities%20of%20Alanine%20aminotransferase.pdf Shamsul Bahari Shamsudin and Hang Yap T (2011) Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers. American Medical Journal, 2 (2). pp. 87-92.
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic HD Industries. Land use. Labor
spellingShingle HD Industries. Land use. Labor
Shamsul Bahari Shamsudin
Hang Yap T
Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers
description Most vegetable farmers are using agricultural chemicals on their farms. Many of these chemicals are used to control pests and are known as pesticides. Pesticides can be considered according to their chemical basis. Most of the more toxic pesticides fall into chemical groups of organophosphates, carbamates and bipyridyls. Approach: The general objective to study the level of liver enzymes as a result of being exposed to pesticides among the farmers in Muar, Johor. The specific objectives of the study are to identified relationship between pesticides exposure durations with the liver enzyme level, frequency handling the pesticides and using PPE when application the pesticides, compare the liver enzyme level between exposure group and comparative group and finally identified the factor which can influence the liver enzyme lever at farmer who exposed to pesticides. The cross sectional study on the effect of pesticides to the liver enzymes among farmer at Muar Johor was conducted by using the liver enzymes such as Alanine Aminotransferase (ALAT) and g-Glutamyltranspeptidase (GGT) as indicators. 92 workers were selected as respondents, where 47 respondents are in the exposed group and the other 45 respondents in the comparative group. Respondents had been selected from farmers in Muar as the exposed group and respondents who from Terengganu Health District Office as the comparative group. The selection of the respondents was made through purposive sampling from list provided. The liver enzymes level was measured by taking blood from respondent. The Automatic Analyzer Hitachi 902 was used in the blood analysis. Two types of the liver enzymes (ALAT and GGT) were analyzed. Results: Mean GGT for exposed group was 63.5 Units/L and ALAT was 61.9 Units/L, significantly higher compare to comparative group while the mean of GGT was 20.7 Units/L and ALAT was 23 Units/L. Non-parametric difference Mann-Whitney U test showed there was significant different between exposed and comparative group on GGT (Z = -6.535; p£0.001) and ALAT level (Z = -5.315; p£0.001). Five occupational factors have been measured in this study which is years of working, number of pesticide used per day, frequency of handling pesticide per day, pesticide spraying durations and Personal Protective Equipment (PPE) scores. Result showed both GGT and ALAT enzymes level has significant correlations with pesticide spraying durations (r = 412; p = 0.004 and r = 0.445; p = 0.002) and Personal Protective Equipment(PPE) scores (r = -0.397; p = 0.006 and r = -0.478; p = 0.001). Pesticides spraying durations was the occupational exposure factoring which most influence GGT (b = 0.710; p<0.001) and ALAT (b = 0.574; p<0.001) enzymes level among exposed group after adjustments for all confounders in this study. Conclusion: After adjustments of the confounding factors, result shows that frequency of handling pesticide per day and pesticide spraying duration (hours) influence the enzyme GGT level among exposed workers, meanwhile years of working and pesticide spraying duration (hours) influence the enzyme ALAT level among exposed workers.
format Article
author Shamsul Bahari Shamsudin
Hang Yap T
author_facet Shamsul Bahari Shamsudin
Hang Yap T
author_sort Shamsul Bahari Shamsudin
title Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers
title_short Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers
title_full Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers
title_fullStr Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers
title_full_unstemmed Occupational exposure of pesticides on activities of Alanine aminotransferase (ALAT) and G-glutamyltranspeptidase (GGT) in blood among vegetables farmers
title_sort occupational exposure of pesticides on activities of alanine aminotransferase (alat) and g-glutamyltranspeptidase (ggt) in blood among vegetables farmers
publishDate 2011
url https://eprints.ums.edu.my/id/eprint/19686/1/Occupational%20exposure%20of%20pesticides%20on%20activities%20of%20Alanine%20aminotransferase.pdf
https://eprints.ums.edu.my/id/eprint/19686/
_version_ 1760229614228078592
score 13.211869

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