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Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß)

Gynura procumbens is a medicinal plant, traditionally used to treat inflammation and fever. A yeast-based assay detected GSK3â-inhibitory activity in the aqueous extract of G. procumbens. GSK3â is now known to have a central role in the modulation of host inflammatory response during bacterial infec...

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Main Authors: Sok, Kuan Wong, Lee, Michelle Sue Jann, Suhaini Sudi, Wan Rozianoor Mohd Hassan, Lee, Ping Chin, Noor Embi, Hasidah Mohd Sidek
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2015
Subjects:
RC Internal medicine
Online Access:https://eprints.ums.edu.my/id/eprint/19001/1/Anti.....pdf
https://eprints.ums.edu.my/id/eprint/19001/
https://ukm.pure.elsevier.com/en/publications/anti-malarial-and-anti-inflammatory-effects-of-gynura-procumbens-
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spelling my.ums.eprints.190012018-02-28T06:49:49Z https://eprints.ums.edu.my/id/eprint/19001/ Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß) Sok, Kuan Wong Lee, Michelle Sue Jann Suhaini Sudi Wan Rozianoor Mohd Hassan Lee, Ping Chin Noor Embi Hasidah Mohd Sidek RC Internal medicine Gynura procumbens is a medicinal plant, traditionally used to treat inflammation and fever. A yeast-based assay detected GSK3â-inhibitory activity in the aqueous extract of G. procumbens. GSK3â is now known to have a central role in the modulation of host inflammatory response during bacterial infections. In this study, we investigated the involvement of GSK3â in the anti-malarial and anti-inflammatory effects of an aqueous extract of G. procumbens. Our results showed that G. procumbens inhibited growth of P. falciparum 3D7. Consecutive four-day administration of 250 mg/kg body weight (b.w.) G. procumbens resulted in strong chemosuppression and improved survivability in P. berghei-infected mice. B. pseudomallei-infected mice treated with G. procumbens (50 mg/kg b.w.) showed increased survivability. TNF-á and IFN-ã levels in liver and serum of B. pseudomallei-infected mice were lowered by G. procumbens treatment. IL-10 level was higher in serum of G. procumbens-administered infected mice. G. procumbens treatment of P. berghei-and B. pseudomallei-infected animals each resulted in increased hepatic GSK3â (Ser9) phosphorylation. It is noteworthy that kaempferol (one of the compounds in G. procumbens) also inhibited the growth of P. falciparum 3D7; showed strong chemosuppression and improved survivability in P. berghei-infected mice at 5 mg/kg b.w. B. pseudomallei-infected mice treated with kaempferol (10 mg/kg b.w.) showed improved survivability. Concomitantly, the described effects due to kaempferol also involved enhanced GSK3â (Ser9) phosphorylation as observed with G. procumbens. In summary, the observed anti-malarial and anti-inflammatory effects of G. procumbens involved inhibition of GSK3â and kaempferol may in part be responsible for the pharmacological effects. Penerbit Universiti Kebangsaan Malaysia 2015 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/19001/1/Anti.....pdf Sok, Kuan Wong and Lee, Michelle Sue Jann and Suhaini Sudi and Wan Rozianoor Mohd Hassan and Lee, Ping Chin and Noor Embi and Hasidah Mohd Sidek (2015) Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß). Sains Malaysiana, 44 (10). pp. 1489-1500. ISSN 0126-6039 https://ukm.pure.elsevier.com/en/publications/anti-malarial-and-anti-inflammatory-effects-of-gynura-procumbens-
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic RC Internal medicine
spellingShingle RC Internal medicine
Sok, Kuan Wong
Lee, Michelle Sue Jann
Suhaini Sudi
Wan Rozianoor Mohd Hassan
Lee, Ping Chin
Noor Embi
Hasidah Mohd Sidek
Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß)
description Gynura procumbens is a medicinal plant, traditionally used to treat inflammation and fever. A yeast-based assay detected GSK3â-inhibitory activity in the aqueous extract of G. procumbens. GSK3â is now known to have a central role in the modulation of host inflammatory response during bacterial infections. In this study, we investigated the involvement of GSK3â in the anti-malarial and anti-inflammatory effects of an aqueous extract of G. procumbens. Our results showed that G. procumbens inhibited growth of P. falciparum 3D7. Consecutive four-day administration of 250 mg/kg body weight (b.w.) G. procumbens resulted in strong chemosuppression and improved survivability in P. berghei-infected mice. B. pseudomallei-infected mice treated with G. procumbens (50 mg/kg b.w.) showed increased survivability. TNF-á and IFN-ã levels in liver and serum of B. pseudomallei-infected mice were lowered by G. procumbens treatment. IL-10 level was higher in serum of G. procumbens-administered infected mice. G. procumbens treatment of P. berghei-and B. pseudomallei-infected animals each resulted in increased hepatic GSK3â (Ser9) phosphorylation. It is noteworthy that kaempferol (one of the compounds in G. procumbens) also inhibited the growth of P. falciparum 3D7; showed strong chemosuppression and improved survivability in P. berghei-infected mice at 5 mg/kg b.w. B. pseudomallei-infected mice treated with kaempferol (10 mg/kg b.w.) showed improved survivability. Concomitantly, the described effects due to kaempferol also involved enhanced GSK3â (Ser9) phosphorylation as observed with G. procumbens. In summary, the observed anti-malarial and anti-inflammatory effects of G. procumbens involved inhibition of GSK3â and kaempferol may in part be responsible for the pharmacological effects.
format Article
author Sok, Kuan Wong
Lee, Michelle Sue Jann
Suhaini Sudi
Wan Rozianoor Mohd Hassan
Lee, Ping Chin
Noor Embi
Hasidah Mohd Sidek
author_facet Sok, Kuan Wong
Lee, Michelle Sue Jann
Suhaini Sudi
Wan Rozianoor Mohd Hassan
Lee, Ping Chin
Noor Embi
Hasidah Mohd Sidek
author_sort Sok, Kuan Wong
title Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß)
title_short Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß)
title_full Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß)
title_fullStr Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß)
title_full_unstemmed Anti-malarial and anti-inflammatory effects of Gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (GSK3ß)
title_sort anti-malarial and anti-inflammatory effects of gynura procumbens are mediated by kaempferol via inhibition of glycogen synthase kinase-3ß (gsk3ß)
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2015
url https://eprints.ums.edu.my/id/eprint/19001/1/Anti.....pdf
https://eprints.ums.edu.my/id/eprint/19001/
https://ukm.pure.elsevier.com/en/publications/anti-malarial-and-anti-inflammatory-effects-of-gynura-procumbens-
_version_ 1760229522255380480
score 13.211869

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