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Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats

Glyceryl trinitrate (GTN) has been used widely as a potent vasodilator to treat heart conditions, such as angina pectoris and chronic heart failure. This study aims to elucidate the effect of exogenous nitric oxide (NO) administration, using GTN, on carbon tetrachloride (CCl4)-induced oxidative stre...

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Main Authors: Abdul Rahman, Mohamad Iqbal, SM Vasenwala
Format: Article
Language:English
Published: SAGE Publications 2017
Subjects:
RA Public aspects of medicine
Online Access:https://eprints.ums.edu.my/id/eprint/18804/1/Hepatoprotective%20potential%20of%20glyceryl%20trinitrate%20against%20chemically%20induced%20oxidative%20stress%20and%20hepatic%20injury%20in%20rats.pdf
https://eprints.ums.edu.my/id/eprint/18804/
https://doi.org/10.1177/0960327116665675
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spelling my.ums.eprints.188042018-02-18T11:56:54Z https://eprints.ums.edu.my/id/eprint/18804/ Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats Abdul Rahman Mohamad Iqbal SM Vasenwala RA Public aspects of medicine Glyceryl trinitrate (GTN) has been used widely as a potent vasodilator to treat heart conditions, such as angina pectoris and chronic heart failure. This study aims to elucidate the effect of exogenous nitric oxide (NO) administration, using GTN, on carbon tetrachloride (CCl4)-induced oxidative stress and liver injury in rats. The results obtained demonstrated that NO generated by the administration of GTN affords protection against CCl4-induced oxidative stress and liver injury. Administration of CCl4 resulted in a significant (p < 0.001) increase in lipid peroxidation and tissue damage markers (aspartate and alanine transaminase and lactate dehydrogenase) release in serum. Parallel to these changes, CCl4 also caused downregulation of antioxidant enzymes including glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST), and several fold induction in γ-glutamyl transpeptidase (GGT) activity. Subsequent administration of GTN resulted in significant (p < 0.001) recovery of GSH-metabolizing enzymes in a dose-dependent manner. Further, administration of NO inhibitor, NG-nitro-l-arginine methyl ester (l-NAME), exacerbated CCl4-induced oxidative tissue injury. Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats. SAGE Publications 2017 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/18804/1/Hepatoprotective%20potential%20of%20glyceryl%20trinitrate%20against%20chemically%20induced%20oxidative%20stress%20and%20hepatic%20injury%20in%20rats.pdf Abdul Rahman and Mohamad Iqbal and SM Vasenwala (2017) Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats. Human & Experimental Toxicology, 36 (8). pp. 785-794. ISSN 1477-0903 https://doi.org/10.1177/0960327116665675
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic RA Public aspects of medicine
spellingShingle RA Public aspects of medicine
Abdul Rahman
Mohamad Iqbal
SM Vasenwala
Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats
description Glyceryl trinitrate (GTN) has been used widely as a potent vasodilator to treat heart conditions, such as angina pectoris and chronic heart failure. This study aims to elucidate the effect of exogenous nitric oxide (NO) administration, using GTN, on carbon tetrachloride (CCl4)-induced oxidative stress and liver injury in rats. The results obtained demonstrated that NO generated by the administration of GTN affords protection against CCl4-induced oxidative stress and liver injury. Administration of CCl4 resulted in a significant (p < 0.001) increase in lipid peroxidation and tissue damage markers (aspartate and alanine transaminase and lactate dehydrogenase) release in serum. Parallel to these changes, CCl4 also caused downregulation of antioxidant enzymes including glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST), and several fold induction in γ-glutamyl transpeptidase (GGT) activity. Subsequent administration of GTN resulted in significant (p < 0.001) recovery of GSH-metabolizing enzymes in a dose-dependent manner. Further, administration of NO inhibitor, NG-nitro-l-arginine methyl ester (l-NAME), exacerbated CCl4-induced oxidative tissue injury. Overall, the study suggests that GTN might suppress oxidant-induced tissue injury and hepatotoxicity in rats.
format Article
author Abdul Rahman
Mohamad Iqbal
SM Vasenwala
author_facet Abdul Rahman
Mohamad Iqbal
SM Vasenwala
author_sort Abdul Rahman
title Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats
title_short Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats
title_full Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats
title_fullStr Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats
title_full_unstemmed Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats
title_sort hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats
publisher SAGE Publications
publishDate 2017
url https://eprints.ums.edu.my/id/eprint/18804/1/Hepatoprotective%20potential%20of%20glyceryl%20trinitrate%20against%20chemically%20induced%20oxidative%20stress%20and%20hepatic%20injury%20in%20rats.pdf
https://eprints.ums.edu.my/id/eprint/18804/
https://doi.org/10.1177/0960327116665675
_version_ 1760229495483138048
score 13.211869

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