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Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method

A research was conducted on the screening of carbamazepine-ibuprofen co-crystal formation using stoichiometric method via co-grinding and solvent evaporation. Pharmaceutical co-crystals formation have been proven useful in enhancing the solubility, dissolution rate, stability, and bioavailability of...

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Main Author: Siti Salasiah, Mohd Khalid
Format: Undergraduates Project Papers
Language:English
Published: 2014
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/9012/1/CD8600%20%40%2028.pdf
http://umpir.ump.edu.my/id/eprint/9012/
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spelling my.ump.umpir.90122021-07-22T03:54:33Z http://umpir.ump.edu.my/id/eprint/9012/ Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method Siti Salasiah, Mohd Khalid TP Chemical technology A research was conducted on the screening of carbamazepine-ibuprofen co-crystal formation using stoichiometric method via co-grinding and solvent evaporation. Pharmaceutical co-crystals formation have been proven useful in enhancing the solubility, dissolution rate, stability, and bioavailability of APIs and recognized as the promising alternative to improve APIs properties. Thus, the purpose of this research is to determine the co-crystal formation of carbamazepine-ibuprofen (CBZ-IBU) using stoichiometric methods. In this method, two techniques are used which are solvent evaporation and co-grinding by using ethanol, acetonitrile, ethyl acetate, propanol and formic acid as a solvent. Then, the produced crystal was characterized using differential scanning calorimetry (DSC) and optical microscopy. From this research, it is shown the morphology of the crystals obtained shows prismatic blade like (isometric) morphology indicated that these crystals refer to IBU confirmed by DSC results. The findings concluded that co-crystal was not being able to be formed via these methods of screening 2014-01 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/9012/1/CD8600%20%40%2028.pdf Siti Salasiah, Mohd Khalid (2014) Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method. Faculty Of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang.
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Siti Salasiah, Mohd Khalid
Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method
description A research was conducted on the screening of carbamazepine-ibuprofen co-crystal formation using stoichiometric method via co-grinding and solvent evaporation. Pharmaceutical co-crystals formation have been proven useful in enhancing the solubility, dissolution rate, stability, and bioavailability of APIs and recognized as the promising alternative to improve APIs properties. Thus, the purpose of this research is to determine the co-crystal formation of carbamazepine-ibuprofen (CBZ-IBU) using stoichiometric methods. In this method, two techniques are used which are solvent evaporation and co-grinding by using ethanol, acetonitrile, ethyl acetate, propanol and formic acid as a solvent. Then, the produced crystal was characterized using differential scanning calorimetry (DSC) and optical microscopy. From this research, it is shown the morphology of the crystals obtained shows prismatic blade like (isometric) morphology indicated that these crystals refer to IBU confirmed by DSC results. The findings concluded that co-crystal was not being able to be formed via these methods of screening
format Undergraduates Project Papers
author Siti Salasiah, Mohd Khalid
author_facet Siti Salasiah, Mohd Khalid
author_sort Siti Salasiah, Mohd Khalid
title Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method
title_short Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method
title_full Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method
title_fullStr Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method
title_full_unstemmed Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method
title_sort screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method
publishDate 2014
url http://umpir.ump.edu.my/id/eprint/9012/1/CD8600%20%40%2028.pdf
http://umpir.ump.edu.my/id/eprint/9012/
_version_ 1706957184768671744
score 13.211869

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