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Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis

Xylose reductase (XR) is an oxidoreductase having potential applications in the production of various specialty products, mainly xylitol. It is important to screen for compounds that can decrease XR activity and consequently can decrease xylitol production. We have identified the byproducts in...

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Main Authors: M. Rafiqul, Islam, Mimi Sakinah, A. M., Zularisam, A. W.
Format: Article
Language:English
Published: Springer Netherlands 2014
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/7993/1/Rafiq-2014b_%28BILE%29_%281%29.pdf
http://umpir.ump.edu.my/id/eprint/7993/
http://dx.doi.org/10.1007/s10529-014-1672-5
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spelling my.ump.umpir.79932018-11-29T07:26:06Z http://umpir.ump.edu.my/id/eprint/7993/ Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis M. Rafiqul, Islam Mimi Sakinah, A. M. Zularisam, A. W. TP Chemical technology Xylose reductase (XR) is an oxidoreductase having potential applications in the production of various specialty products, mainly xylitol. It is important to screen for compounds that can decrease XR activity and consequently can decrease xylitol production. We have identified the byproducts in the hemicellulosic hydrolysate that inhibit XR from Candida tropicalis and measured their effects. XR inhibitory activities of byproducts, glucose, acetic acid, arabinose, lignin-degradation products (LDPs), furfural and hydroxymethylfurfural (HMF), were evaluated by measuring the MIC and IC50 values. XR activity was 11.2 U/ml. Acetic acid, LDPs, furfural and HMF significantly inhibited XR with IC50 values of 11, 6.4, 2.3 and 0.4 g/l, respectively. This is the first report on the inhibitory activities of several byproducts for XR. Springer Netherlands 2014-09-12 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7993/1/Rafiq-2014b_%28BILE%29_%281%29.pdf M. Rafiqul, Islam and Mimi Sakinah, A. M. and Zularisam, A. W. (2014) Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis. Biotechnology Letters, 37 (1). pp. 191-196. ISSN 1573-6776 http://dx.doi.org/10.1007/s10529-014-1672-5 DOI: 10.1007/s10529-014-1672-5
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
M. Rafiqul, Islam
Mimi Sakinah, A. M.
Zularisam, A. W.
Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis
description Xylose reductase (XR) is an oxidoreductase having potential applications in the production of various specialty products, mainly xylitol. It is important to screen for compounds that can decrease XR activity and consequently can decrease xylitol production. We have identified the byproducts in the hemicellulosic hydrolysate that inhibit XR from Candida tropicalis and measured their effects. XR inhibitory activities of byproducts, glucose, acetic acid, arabinose, lignin-degradation products (LDPs), furfural and hydroxymethylfurfural (HMF), were evaluated by measuring the MIC and IC50 values. XR activity was 11.2 U/ml. Acetic acid, LDPs, furfural and HMF significantly inhibited XR with IC50 values of 11, 6.4, 2.3 and 0.4 g/l, respectively. This is the first report on the inhibitory activities of several byproducts for XR.
format Article
author M. Rafiqul, Islam
Mimi Sakinah, A. M.
Zularisam, A. W.
author_facet M. Rafiqul, Islam
Mimi Sakinah, A. M.
Zularisam, A. W.
author_sort M. Rafiqul, Islam
title Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis
title_short Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis
title_full Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis
title_fullStr Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis
title_full_unstemmed Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis
title_sort inhibition by toxic compounds in the hemicellulosic hydrolysates on the activity of xylose reductase from candida tropicalis
publisher Springer Netherlands
publishDate 2014
url http://umpir.ump.edu.my/id/eprint/7993/1/Rafiq-2014b_%28BILE%29_%281%29.pdf
http://umpir.ump.edu.my/id/eprint/7993/
http://dx.doi.org/10.1007/s10529-014-1672-5
_version_ 1643665768732164096
score 13.211869

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