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Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats

We evaluated the effects of a standardized Labisia pumila var. alata (LPva) extract on body weight change, hydroxysteroid (11-beta) dehydrogenase 1 (HSD1 1B1) expressions and corticosterone (CORT) level in ovariectomized (OVX) rats. The decoction of LPva has been used for generations among Malay wo...

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Main Authors: M. M., Yusoff, Fazliana, Mansor, Gu, Harvest F., Östenson, Claes-Göran, Wan Mohamud, Wan Nazaimoon
Format: Article
Language:English
Published: Springer Japan 2012
Subjects:
Q Science (General)
Online Access:http://umpir.ump.edu.my/id/eprint/4728/1/Labisia%20pumila%20extract%20down-regulates%20hydroxysteroid%20%2811-beta%29.pdf
http://umpir.ump.edu.my/id/eprint/4728/
https://doi.org/10.1007/s11418-011-0575-1
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spelling my.ump.umpir.47282018-07-27T03:26:46Z http://umpir.ump.edu.my/id/eprint/4728/ Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats M. M., Yusoff Fazliana, Mansor Gu, Harvest F. Östenson, Claes-Göran Wan Mohamud, Wan Nazaimoon Q Science (General) We evaluated the effects of a standardized Labisia pumila var. alata (LPva) extract on body weight change, hydroxysteroid (11-beta) dehydrogenase 1 (HSD1 1B1) expressions and corticosterone (CORT) level in ovariectomized (OVX) rats. The decoction of LPva has been used for generations among Malay women in Malaysia to maintain a healthy reproductive system.Thirty-six Sprague–Dawley OVX rats were treated orally with LPva extract (10, 20 or 50 mg/kg/day) or estrogen replacement (ERT) for 30 days. Sham operated rats were used as controls. Compared to untreated OVX rats, LPva-treated rats showed less weight gain and had significantly down-regulated HSD11B1 mRNA in liver tissues. HSD11B1 mRNA in adipose tissues increased by 55% (p\0.05) in OVX rats but normalized in rats treated with LPva. Similarly, there was significant down-regulation (p\0.05) of protein levels of HSD11B1 in both liver and adipose tissue of LPva and ERT groups, and CORT levels were significantly reduced in both groups of rats. This is the first study ever conducted to evaluate the beneficial effects of LPva in relation to weight gain caused by estrogen insufficiency. Results implied that the bioactive components in LPva extract affect not only HSD11B1 expressions in both adipose and liver tissues but also decrease circulating CORT. The extract should be explored for its potential use as a natural remedy for weight management. Springer Japan 2012-04 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/4728/1/Labisia%20pumila%20extract%20down-regulates%20hydroxysteroid%20%2811-beta%29.pdf M. M., Yusoff and Fazliana, Mansor and Gu, Harvest F. and Östenson, Claes-Göran and Wan Mohamud, Wan Nazaimoon (2012) Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats. Journal of Natural Medicines, 66 (2). pp. 257-264. ISSN 1340-3443(print); 1861-0293(online) https://doi.org/10.1007/s11418-011-0575-1 DOI: 10.1007/s11418-011-0575-1
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
M. M., Yusoff
Fazliana, Mansor
Gu, Harvest F.
Östenson, Claes-Göran
Wan Mohamud, Wan Nazaimoon
Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
description We evaluated the effects of a standardized Labisia pumila var. alata (LPva) extract on body weight change, hydroxysteroid (11-beta) dehydrogenase 1 (HSD1 1B1) expressions and corticosterone (CORT) level in ovariectomized (OVX) rats. The decoction of LPva has been used for generations among Malay women in Malaysia to maintain a healthy reproductive system.Thirty-six Sprague–Dawley OVX rats were treated orally with LPva extract (10, 20 or 50 mg/kg/day) or estrogen replacement (ERT) for 30 days. Sham operated rats were used as controls. Compared to untreated OVX rats, LPva-treated rats showed less weight gain and had significantly down-regulated HSD11B1 mRNA in liver tissues. HSD11B1 mRNA in adipose tissues increased by 55% (p\0.05) in OVX rats but normalized in rats treated with LPva. Similarly, there was significant down-regulation (p\0.05) of protein levels of HSD11B1 in both liver and adipose tissue of LPva and ERT groups, and CORT levels were significantly reduced in both groups of rats. This is the first study ever conducted to evaluate the beneficial effects of LPva in relation to weight gain caused by estrogen insufficiency. Results implied that the bioactive components in LPva extract affect not only HSD11B1 expressions in both adipose and liver tissues but also decrease circulating CORT. The extract should be explored for its potential use as a natural remedy for weight management.
format Article
author M. M., Yusoff
Fazliana, Mansor
Gu, Harvest F.
Östenson, Claes-Göran
Wan Mohamud, Wan Nazaimoon
author_facet M. M., Yusoff
Fazliana, Mansor
Gu, Harvest F.
Östenson, Claes-Göran
Wan Mohamud, Wan Nazaimoon
author_sort M. M., Yusoff
title Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_short Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_full Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_fullStr Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_full_unstemmed Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_sort labisia pumila extract down-regulates hydroxysteroid (11-beta) dehydrogenase 1 expression and corticosterone levels in ovariectomized rats
publisher Springer Japan
publishDate 2012
url http://umpir.ump.edu.my/id/eprint/4728/1/Labisia%20pumila%20extract%20down-regulates%20hydroxysteroid%20%2811-beta%29.pdf
http://umpir.ump.edu.my/id/eprint/4728/
https://doi.org/10.1007/s11418-011-0575-1
_version_ 1643665047743889408
score 13.211869

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