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Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release

To evaluate the antidiabetic properties of borapetol B known as compound 1 (C1) isolated from Tinospora crispa in normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats. Methods. The effect of C1 on blood glucose and plasma insulin was assessed by an oral glucose...

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Main Authors: Lokman, Faradianna E., Harvest, F. Gu, Wan Nazaimoon, Wan Mohamud, M. M., Yusoff, Keh, Leong Chia, Claes-Göran, Östenson
Format: Article
Language:English
Published: 2013
Subjects:
QD Chemistry
Online Access:http://umpir.ump.edu.my/id/eprint/4695/1/Antidiabetic_Effect_of_Oral_Borapetol_B_Compound%2C_Isolated_from_the_Plant_Tinospora_crispa%2C_by_Stimulating_Insulin_Release.pdf
http://umpir.ump.edu.my/id/eprint/4695/
http://www.hindawi.com/journals/ecam/2013/727602
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spelling my.ump.umpir.46952018-07-27T01:42:27Z http://umpir.ump.edu.my/id/eprint/4695/ Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release Lokman, Faradianna E. Harvest, F. Gu Wan Nazaimoon, Wan Mohamud M. M., Yusoff Keh, Leong Chia Claes-Göran, Östenson QD Chemistry To evaluate the antidiabetic properties of borapetol B known as compound 1 (C1) isolated from Tinospora crispa in normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats. Methods. The effect of C1 on blood glucose and plasma insulin was assessed by an oral glucose tolerance test. The effect of C1 on insulin secretion was assessed by batch incubation and perifusion experiments using isolated pancreatic islets. Results. An acute oral administration of C1 improved blood glucose levels in treated versus placebo groups with areas under glucose curves 0–120 min being versus  mmol/L () and versus  mmol/L () in W and GK rats, respectively. Plasma insulin levels were increased by 2-fold in treated W and GK rats versus placebo group at 30 min (). C1 dose-dependently increased insulin secretion from W and GK isolated islets at 3.3 mM and 16.7 mM glucose. The perifusions of isolated islets indicated that C1 did not cause leakage of insulin by damaging islet beta cells (). Conclusion. This study provides evidence that borapetol B (C1) has antidiabetic properties mainly due to its stimulation of insulin release. 2013-09-12 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/4695/1/Antidiabetic_Effect_of_Oral_Borapetol_B_Compound%2C_Isolated_from_the_Plant_Tinospora_crispa%2C_by_Stimulating_Insulin_Release.pdf Lokman, Faradianna E. and Harvest, F. Gu and Wan Nazaimoon, Wan Mohamud and M. M., Yusoff and Keh, Leong Chia and Claes-Göran, Östenson (2013) Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release. Evidence-Based Complementary and Alternative Medicine , 2013. http://www.hindawi.com/journals/ecam/2013/727602 Article ID 727602
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Lokman, Faradianna E.
Harvest, F. Gu
Wan Nazaimoon, Wan Mohamud
M. M., Yusoff
Keh, Leong Chia
Claes-Göran, Östenson
Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
description To evaluate the antidiabetic properties of borapetol B known as compound 1 (C1) isolated from Tinospora crispa in normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats. Methods. The effect of C1 on blood glucose and plasma insulin was assessed by an oral glucose tolerance test. The effect of C1 on insulin secretion was assessed by batch incubation and perifusion experiments using isolated pancreatic islets. Results. An acute oral administration of C1 improved blood glucose levels in treated versus placebo groups with areas under glucose curves 0–120 min being versus  mmol/L () and versus  mmol/L () in W and GK rats, respectively. Plasma insulin levels were increased by 2-fold in treated W and GK rats versus placebo group at 30 min (). C1 dose-dependently increased insulin secretion from W and GK isolated islets at 3.3 mM and 16.7 mM glucose. The perifusions of isolated islets indicated that C1 did not cause leakage of insulin by damaging islet beta cells (). Conclusion. This study provides evidence that borapetol B (C1) has antidiabetic properties mainly due to its stimulation of insulin release.
format Article
author Lokman, Faradianna E.
Harvest, F. Gu
Wan Nazaimoon, Wan Mohamud
M. M., Yusoff
Keh, Leong Chia
Claes-Göran, Östenson
author_facet Lokman, Faradianna E.
Harvest, F. Gu
Wan Nazaimoon, Wan Mohamud
M. M., Yusoff
Keh, Leong Chia
Claes-Göran, Östenson
author_sort Lokman, Faradianna E.
title Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
title_short Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
title_full Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
title_fullStr Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
title_full_unstemmed Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
title_sort antidiabetic effect of oral borapetol b compound, isolated from the plant tinospora crispa, by stimulating insulin release
publishDate 2013
url http://umpir.ump.edu.my/id/eprint/4695/1/Antidiabetic_Effect_of_Oral_Borapetol_B_Compound%2C_Isolated_from_the_Plant_Tinospora_crispa%2C_by_Stimulating_Insulin_Release.pdf
http://umpir.ump.edu.my/id/eprint/4695/
http://www.hindawi.com/journals/ecam/2013/727602
_version_ 1643665039250423808
score 13.211869

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