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Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting

Restenosis typically occurs in regions of low and oscillating wall shear stress, which also favor the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to evaluate LDL transport and accumulation at the carotid artery bifurcation following carotid arter...

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Main Authors: Nasrul Hadi, Johari, Menichini, Claudia, Hamady, Mohamad S., Xu, Xiaoyun
Format: Article
Language:English
Published: John Wiley and Sons Inc 2023
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
Online Access:http://umpir.ump.edu.my/id/eprint/42877/1/Computational%20modeling%20of%20low-density%20lipoprotein%20accumulation.pdf
http://umpir.ump.edu.my/id/eprint/42877/
https://doi.org/10.1002/cnm.3772
https://doi.org/10.1002/cnm.3772
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spelling my.ump.umpir.428772025-01-07T05:00:25Z http://umpir.ump.edu.my/id/eprint/42877/ Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting Nasrul Hadi, Johari Menichini, Claudia Hamady, Mohamad S. Xu, Xiaoyun T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics Restenosis typically occurs in regions of low and oscillating wall shear stress, which also favor the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to evaluate LDL transport and accumulation at the carotid artery bifurcation following carotid artery stenting (CAS) by means of computational simulation. The computational model consists of coupled blood flow and LDL transport, with the latter being modeled as a dilute substance dissolved in the blood and transported by the flow through a convection-diffusion transport equation. The endothelial layer was assumed to be permeable to LDL, and the hydraulic conductivity of LDL was shear-dependent. Anatomically realistic geometric models of the carotid bifurcation were built based on pre- and post-stent computed tomography (CT) scans. The influence of stent design was investigated by virtually deploying two different types of stents (open- and closed-cell stents) into the same carotid bifurcation model. Predicted LDL concentrations were compared between the post-stent carotid models and the relatively normal contralateral model reconstructed from patient-specific CT images. Our results show elevated LDL concentration in the distal section of the stent in all post-stent models, where LDL concentration is 20 times higher than that in the contralateral carotid. Compared with the open-cell stents, the closed-cell stents have larger areas exposed to high LDL concentration, suggesting an increased risk of stent restenosis. This computational approach is readily applicable to multiple patient studies and, once fully validated against follow-up data, it can help elucidate the role of stent strut design in the development of in-stent restenosis after CAS. John Wiley and Sons Inc 2023-12 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/42877/1/Computational%20modeling%20of%20low-density%20lipoprotein%20accumulation.pdf Nasrul Hadi, Johari and Menichini, Claudia and Hamady, Mohamad S. and Xu, Xiaoyun (2023) Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting. International Journal for Numerical Methods in Biomedical Engineering, 39 (e3772). pp. 1-16. ISSN 2040-7939. (Published) https://doi.org/10.1002/cnm.3772 https://doi.org/10.1002/cnm.3772
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
Nasrul Hadi, Johari
Menichini, Claudia
Hamady, Mohamad S.
Xu, Xiaoyun
Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting
description Restenosis typically occurs in regions of low and oscillating wall shear stress, which also favor the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to evaluate LDL transport and accumulation at the carotid artery bifurcation following carotid artery stenting (CAS) by means of computational simulation. The computational model consists of coupled blood flow and LDL transport, with the latter being modeled as a dilute substance dissolved in the blood and transported by the flow through a convection-diffusion transport equation. The endothelial layer was assumed to be permeable to LDL, and the hydraulic conductivity of LDL was shear-dependent. Anatomically realistic geometric models of the carotid bifurcation were built based on pre- and post-stent computed tomography (CT) scans. The influence of stent design was investigated by virtually deploying two different types of stents (open- and closed-cell stents) into the same carotid bifurcation model. Predicted LDL concentrations were compared between the post-stent carotid models and the relatively normal contralateral model reconstructed from patient-specific CT images. Our results show elevated LDL concentration in the distal section of the stent in all post-stent models, where LDL concentration is 20 times higher than that in the contralateral carotid. Compared with the open-cell stents, the closed-cell stents have larger areas exposed to high LDL concentration, suggesting an increased risk of stent restenosis. This computational approach is readily applicable to multiple patient studies and, once fully validated against follow-up data, it can help elucidate the role of stent strut design in the development of in-stent restenosis after CAS.
format Article
author Nasrul Hadi, Johari
Menichini, Claudia
Hamady, Mohamad S.
Xu, Xiaoyun
author_facet Nasrul Hadi, Johari
Menichini, Claudia
Hamady, Mohamad S.
Xu, Xiaoyun
author_sort Nasrul Hadi, Johari
title Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting
title_short Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting
title_full Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting
title_fullStr Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting
title_full_unstemmed Computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting
title_sort computational modeling of low-density lipoprotein accumulation at the carotid artery bifurcation after stenting
publisher John Wiley and Sons Inc
publishDate 2023
url http://umpir.ump.edu.my/id/eprint/42877/1/Computational%20modeling%20of%20low-density%20lipoprotein%20accumulation.pdf
http://umpir.ump.edu.my/id/eprint/42877/
https://doi.org/10.1002/cnm.3772
https://doi.org/10.1002/cnm.3772
_version_ 1822924893840211968
score 13.235796

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