Staff View: Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor

Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor

This paper presents the utilization of tapered optical fiber (TOF) biosensor for the detection of 17-α-ethinylestradiol (EE2), an estrogen hormone. TOF with a waist diameter of 12 μm was fabricated from single mode fiber using heat and pull method. The tapered area was used as the sensing interface...

Full description

Saved in:

Bibliographic Details
Main Authors:	Rosyati, Hamid, Yasmin, Mustapha Kamil, Ahmad Zaharin, Aris, Muhammad Hafiz, Abu Bakar, Fariza Hanim, Suhailin, Alresheedi, Mohammed Thamer, Ng, Eng Khoon, Mohd Adzir, Mahdi
Format:	Article
Language:	English English
Published:	Elsevier Ltd 2024
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/42555/1/Detection%20of%2017-%CE%B1-Ethinylestradiol%20with%20Bio-Functionalized%20tapered%20optical%20fiber%20sensor_ABST.pdf http://umpir.ump.edu.my/id/eprint/42555/2/Detection%20of%2017-%CE%B1-Ethinylestradiol%20with%20Bio-Functionalized%20tapered%20optical%20fiber%20sensor.pdf http://umpir.ump.edu.my/id/eprint/42555/ https://doi.org/10.1016/j.measurement.2024.115305 https://doi.org/10.1016/j.measurement.2024.115305
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.ump.umpir.42555
record_format	eprints
spelling	my.ump.umpir.425552024-09-10T04:36:53Z http://umpir.ump.edu.my/id/eprint/42555/ Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor Rosyati, Hamid Yasmin, Mustapha Kamil Ahmad Zaharin, Aris Muhammad Hafiz, Abu Bakar Fariza Hanim, Suhailin Alresheedi, Mohammed Thamer Ng, Eng Khoon Mohd Adzir, Mahdi TP Chemical technology This paper presents the utilization of tapered optical fiber (TOF) biosensor for the detection of 17-α-ethinylestradiol (EE2), an estrogen hormone. TOF with a waist diameter of 12 μm was fabricated from single mode fiber using heat and pull method. The tapered area was used as the sensing interface between the evanescent waves propagating around the fiber due to its unique geometry and the attached molecules on the tapered surface. EE2 antibodies were used as biorecognition molecules towards the targeted analyte, EE2. When tested with different concentrations of EE2 within the range of 0.1 ng/L – 1 mg/L, the developed sensor attained a detection limit of 1 ng/L with a sensitivity value of 1.088 nm/ngL-1 within the operation range of 1 – 10 ng/L. The specificity of the sensor was validated by testing the developed sensor with estrone (E1) and no significant wavelength shift was observed. These findings highlight the potential of our approach for sensitive and selective detection of EE2. Elsevier Ltd 2024-07-14 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42555/1/Detection%20of%2017-%CE%B1-Ethinylestradiol%20with%20Bio-Functionalized%20tapered%20optical%20fiber%20sensor_ABST.pdf pdf en http://umpir.ump.edu.my/id/eprint/42555/2/Detection%20of%2017-%CE%B1-Ethinylestradiol%20with%20Bio-Functionalized%20tapered%20optical%20fiber%20sensor.pdf Rosyati, Hamid and Yasmin, Mustapha Kamil and Ahmad Zaharin, Aris and Muhammad Hafiz, Abu Bakar and Fariza Hanim, Suhailin and Alresheedi, Mohammed Thamer and Ng, Eng Khoon and Mohd Adzir, Mahdi (2024) Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor. Measurement, 238 (115305). pp. 1-11. ISSN 0263-2241. (Published) https://doi.org/10.1016/j.measurement.2024.115305 https://doi.org/10.1016/j.measurement.2024.115305
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
building	UMPSA Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Pahang Al-Sultan Abdullah
content_source	UMPSA Institutional Repository
url_provider	http://umpir.ump.edu.my/
language	English English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Rosyati, Hamid Yasmin, Mustapha Kamil Ahmad Zaharin, Aris Muhammad Hafiz, Abu Bakar Fariza Hanim, Suhailin Alresheedi, Mohammed Thamer Ng, Eng Khoon Mohd Adzir, Mahdi Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor
description	This paper presents the utilization of tapered optical fiber (TOF) biosensor for the detection of 17-α-ethinylestradiol (EE2), an estrogen hormone. TOF with a waist diameter of 12 μm was fabricated from single mode fiber using heat and pull method. The tapered area was used as the sensing interface between the evanescent waves propagating around the fiber due to its unique geometry and the attached molecules on the tapered surface. EE2 antibodies were used as biorecognition molecules towards the targeted analyte, EE2. When tested with different concentrations of EE2 within the range of 0.1 ng/L – 1 mg/L, the developed sensor attained a detection limit of 1 ng/L with a sensitivity value of 1.088 nm/ngL-1 within the operation range of 1 – 10 ng/L. The specificity of the sensor was validated by testing the developed sensor with estrone (E1) and no significant wavelength shift was observed. These findings highlight the potential of our approach for sensitive and selective detection of EE2.
format	Article
author	Rosyati, Hamid Yasmin, Mustapha Kamil Ahmad Zaharin, Aris Muhammad Hafiz, Abu Bakar Fariza Hanim, Suhailin Alresheedi, Mohammed Thamer Ng, Eng Khoon Mohd Adzir, Mahdi
author_facet	Rosyati, Hamid Yasmin, Mustapha Kamil Ahmad Zaharin, Aris Muhammad Hafiz, Abu Bakar Fariza Hanim, Suhailin Alresheedi, Mohammed Thamer Ng, Eng Khoon Mohd Adzir, Mahdi
author_sort	Rosyati, Hamid
title	Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor
title_short	Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor
title_full	Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor
title_fullStr	Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor
title_full_unstemmed	Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor
title_sort	detection of 17-α-ethinylestradiol with bio-functionalized tapered optical fiber sensor
publisher	Elsevier Ltd
publishDate	2024
url	http://umpir.ump.edu.my/id/eprint/42555/1/Detection%20of%2017-%CE%B1-Ethinylestradiol%20with%20Bio-Functionalized%20tapered%20optical%20fiber%20sensor_ABST.pdf http://umpir.ump.edu.my/id/eprint/42555/2/Detection%20of%2017-%CE%B1-Ethinylestradiol%20with%20Bio-Functionalized%20tapered%20optical%20fiber%20sensor.pdf http://umpir.ump.edu.my/id/eprint/42555/ https://doi.org/10.1016/j.measurement.2024.115305 https://doi.org/10.1016/j.measurement.2024.115305
_version_	1822924658780930048
score	13.244413

Detection of 17-α-Ethinylestradiol with Bio-Functionalized tapered optical fiber sensor

Similar Items