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Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs

Natural products (NPs) and their derivatives constitute an important source of bioactive pharmaceutical compounds. Due to the increasing interest in NPs, finding new approaches for rapid screening of novel chemistries and evaluating their potential toxicity is of paramount significance. The extensiv...

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Main Authors:	Shahabipour, Fahimeh, Aldhaher, Abdullah, Doseff, Andrea I., Alavian, Seyed Ehsan, Elnour, Adam Hassan Mohammed, Ashammakhi, Nureddin
Format:	Book Chapter
Language:	English English
Published:	Elsevier 2023
Subjects:	T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/42517/1/Use%20of%20microfluidic%20organ-on-a-chip%20systems%20for%20the%20screening.pdf http://umpir.ump.edu.my/id/eprint/42517/2/Use%20of%20microfluidic%20organ-on-a-chip%20systems%20for%20the%20screening%20and%20development%20of%20phytopharmaceuticals%20and%20herbal%20drugs_ABS.pdf http://umpir.ump.edu.my/id/eprint/42517/ https://doi.org/10.1016/B978-0-323-99125-4.00013-5 https://doi.org/10.1016/B978-0-323-99125-4.00013-5
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id	my.ump.umpir.42517
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spelling	my.ump.umpir.425172024-12-02T01:14:16Z http://umpir.ump.edu.my/id/eprint/42517/ Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs Shahabipour, Fahimeh Aldhaher, Abdullah Doseff, Andrea I. Alavian, Seyed Ehsan Elnour, Adam Hassan Mohammed Ashammakhi, Nureddin T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Natural products (NPs) and their derivatives constitute an important source of bioactive pharmaceutical compounds. Due to the increasing interest in NPs, finding new approaches for rapid screening of novel chemistries and evaluating their potential toxicity is of paramount significance. The extensive repertoire of NPs and derivatives and their presence as complex mixtures presents challenges at multiple levels, including the screening for the bioactive components and real-time detection of drugs effects. Recent advances in microfluidic approaches such as organ-on-a-chip, Herbochip, microfluidic biochip, and multiorgan-on-chip have been developed to facilitate the real-time detection of drug effects on cancer cells. Microfluidic devices enable high throughput and reliable detection of drug cytotoxicity in cell-free systems. Here, we review different microfluidic devices, such as Herbochip and organ-on-chip. The impact of these devices is to identify active components from herbal extraction, the potential of helping to understand the mechanisms of botanical drugs, and determining cytotoxicity of new lead compounds. We also highlight the influence of microfluidic devices, such as organ-on-chip and Herbochip, in translating NP activities into the development of drugs toward precision medicine. Elsevier 2023-01-01 Book Chapter PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42517/1/Use%20of%20microfluidic%20organ-on-a-chip%20systems%20for%20the%20screening.pdf pdf en http://umpir.ump.edu.my/id/eprint/42517/2/Use%20of%20microfluidic%20organ-on-a-chip%20systems%20for%20the%20screening%20and%20development%20of%20phytopharmaceuticals%20and%20herbal%20drugs_ABS.pdf Shahabipour, Fahimeh and Aldhaher, Abdullah and Doseff, Andrea I. and Alavian, Seyed Ehsan and Elnour, Adam Hassan Mohammed and Ashammakhi, Nureddin (2023) Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs. In: Phytopharmaceuticals and Herbal Drugs : Prospects and Safety Issues in the Delivery of Natural Products. Elsevier, Amsterdam, Netherlands, pp. 323-339. ISBN 978-032399125-4, 978-032399369-2 https://doi.org/10.1016/B978-0-323-99125-4.00013-5 https://doi.org/10.1016/B978-0-323-99125-4.00013-5
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
building	UMPSA Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Pahang Al-Sultan Abdullah
content_source	UMPSA Institutional Repository
url_provider	http://umpir.ump.edu.my/
language	English English
topic	T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology
spellingShingle	T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Shahabipour, Fahimeh Aldhaher, Abdullah Doseff, Andrea I. Alavian, Seyed Ehsan Elnour, Adam Hassan Mohammed Ashammakhi, Nureddin Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs
description	Natural products (NPs) and their derivatives constitute an important source of bioactive pharmaceutical compounds. Due to the increasing interest in NPs, finding new approaches for rapid screening of novel chemistries and evaluating their potential toxicity is of paramount significance. The extensive repertoire of NPs and derivatives and their presence as complex mixtures presents challenges at multiple levels, including the screening for the bioactive components and real-time detection of drugs effects. Recent advances in microfluidic approaches such as organ-on-a-chip, Herbochip, microfluidic biochip, and multiorgan-on-chip have been developed to facilitate the real-time detection of drug effects on cancer cells. Microfluidic devices enable high throughput and reliable detection of drug cytotoxicity in cell-free systems. Here, we review different microfluidic devices, such as Herbochip and organ-on-chip. The impact of these devices is to identify active components from herbal extraction, the potential of helping to understand the mechanisms of botanical drugs, and determining cytotoxicity of new lead compounds. We also highlight the influence of microfluidic devices, such as organ-on-chip and Herbochip, in translating NP activities into the development of drugs toward precision medicine.
format	Book Chapter
author	Shahabipour, Fahimeh Aldhaher, Abdullah Doseff, Andrea I. Alavian, Seyed Ehsan Elnour, Adam Hassan Mohammed Ashammakhi, Nureddin
author_facet	Shahabipour, Fahimeh Aldhaher, Abdullah Doseff, Andrea I. Alavian, Seyed Ehsan Elnour, Adam Hassan Mohammed Ashammakhi, Nureddin
author_sort	Shahabipour, Fahimeh
title	Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs
title_short	Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs
title_full	Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs
title_fullStr	Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs
title_full_unstemmed	Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs
title_sort	use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs
publisher	Elsevier
publishDate	2023
url	http://umpir.ump.edu.my/id/eprint/42517/1/Use%20of%20microfluidic%20organ-on-a-chip%20systems%20for%20the%20screening.pdf http://umpir.ump.edu.my/id/eprint/42517/2/Use%20of%20microfluidic%20organ-on-a-chip%20systems%20for%20the%20screening%20and%20development%20of%20phytopharmaceuticals%20and%20herbal%20drugs_ABS.pdf http://umpir.ump.edu.my/id/eprint/42517/ https://doi.org/10.1016/B978-0-323-99125-4.00013-5 https://doi.org/10.1016/B978-0-323-99125-4.00013-5
_version_	1822924759566909440
score	13.235796

Use of microﬂuidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs

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