Cover Image

Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors

Diabetes mellitus (DM) is a long-term metabolic disease characterised by a controlled metabolism of fat, carbohydrates, and proteins. In recent decades, it has grown into a significant global public health issue. According to the International Diabetes Federation, there were 425 million DM globally...

Full description

Saved in:
Bibliographic Details
Main Authors: Roney, Miah, Huq, A. K. M. Moyeenul, Rullah, Kamal, Normaiza, Zamri, Mohd Fadhlizil Fasihi, Mohd Aluwi
Format: Article
Language:English
English
Published: Springer 2024
Subjects:
HD Industries. Land use. Labor
Q Science (General)
Online Access:http://umpir.ump.edu.my/id/eprint/42390/1/Curcumin%2C%20a%20bioactive%20compound%20of%20Turmeric%20%28Curcuma%20longa%29%20and%20its%20derivatives.pdf
http://umpir.ump.edu.my/id/eprint/42390/2/Curcumin%2C%20a%20bioactive%20compound%20of%20Turmeric%20%28Curcuma%20longa%29%20and%20its%20derivatives%20as%20%CE%B1-amylase%20and%20%CE%B1-glucosidase%20inhibitors.pdf
http://umpir.ump.edu.my/id/eprint/42390/
https://doi.org/10.1007/s12013-024-01477-5
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.ump.umpir.42390
record_format eprints
spelling my.ump.umpir.423902024-08-19T00:14:54Z http://umpir.ump.edu.my/id/eprint/42390/ Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors Roney, Miah Huq, A. K. M. Moyeenul Rullah, Kamal Normaiza, Zamri Mohd Fadhlizil Fasihi, Mohd Aluwi HD Industries. Land use. Labor Q Science (General) Diabetes mellitus (DM) is a long-term metabolic disease characterised by a controlled metabolism of fat, carbohydrates, and proteins. In recent decades, it has grown into a significant global public health issue. According to the International Diabetes Federation, there were 425 million DM globally in 2017, and the number might be increased to 629 million by 2045 (a global 48% increase). Approximately 4.2 million deaths globally attributed to DM occur before the age of 60. The existing class of anti-diabetic medications is limited by side effects, which has led to the hunt for novel inhibitors that specifically target the α-amylase and α-glucosidase enzymes. Curcumin is a small-molecular-weight compound found in the roots of the Curcuma longa L (C. longa). plant, which has been used for culinary, medicinal, and other purposes throughout Asia for thousands of years. Curcumin has potent anti-inflammatory, anti-cancer, anti-angiogenic, antispasmodic, antibacterial, and anti-parasitic qualities. Even though the potential of curcumin to cure DM has been well investigated, its low solubility, rapid metabolism, and short plasma half-life have limited its application in DM. Therefore, the objectives of this review were to review the chemical composition of C. longa, the structure of curcumin, the degradation of curcumin, and the effects of curcumin derivatives on anti-diabetic properties against α-amylase and α-glucosidase enzymes. The results showed that C. longa contains carbohydrates, moisture, protein, fat, minerals, volatiles, fibre, and curcuminoids. Among the curcuminoids, curcumin is 60–70% present in C. longa. Moreover, curcumin and its derivatives have a lot of potential for treating DM, which was highlighted in this review. This review emphasises the several biological applications of curcumin, which collectively establish the foundation for its anti-diabetic characteristics. Considering these results, curcumin derivatives may be considered as potential agents in the pharmacotherapeutic management of patients with DM. Springer 2024 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42390/1/Curcumin%2C%20a%20bioactive%20compound%20of%20Turmeric%20%28Curcuma%20longa%29%20and%20its%20derivatives.pdf pdf en http://umpir.ump.edu.my/id/eprint/42390/2/Curcumin%2C%20a%20bioactive%20compound%20of%20Turmeric%20%28Curcuma%20longa%29%20and%20its%20derivatives%20as%20%CE%B1-amylase%20and%20%CE%B1-glucosidase%20inhibitors.pdf Roney, Miah and Huq, A. K. M. Moyeenul and Rullah, Kamal and Normaiza, Zamri and Mohd Fadhlizil Fasihi, Mohd Aluwi (2024) Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors. Cell Biochemistry and Biophysics. pp. 1-19. ISSN 1085-9195. (In Press / Online First) (In Press / Online First) https://doi.org/10.1007/s12013-024-01477-5 10.1007/s12013-024-01477-5
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
English
topic HD Industries. Land use. Labor
Q Science (General)
spellingShingle HD Industries. Land use. Labor
Q Science (General)
Roney, Miah
Huq, A. K. M. Moyeenul
Rullah, Kamal
Normaiza, Zamri
Mohd Fadhlizil Fasihi, Mohd Aluwi
Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
description Diabetes mellitus (DM) is a long-term metabolic disease characterised by a controlled metabolism of fat, carbohydrates, and proteins. In recent decades, it has grown into a significant global public health issue. According to the International Diabetes Federation, there were 425 million DM globally in 2017, and the number might be increased to 629 million by 2045 (a global 48% increase). Approximately 4.2 million deaths globally attributed to DM occur before the age of 60. The existing class of anti-diabetic medications is limited by side effects, which has led to the hunt for novel inhibitors that specifically target the α-amylase and α-glucosidase enzymes. Curcumin is a small-molecular-weight compound found in the roots of the Curcuma longa L (C. longa). plant, which has been used for culinary, medicinal, and other purposes throughout Asia for thousands of years. Curcumin has potent anti-inflammatory, anti-cancer, anti-angiogenic, antispasmodic, antibacterial, and anti-parasitic qualities. Even though the potential of curcumin to cure DM has been well investigated, its low solubility, rapid metabolism, and short plasma half-life have limited its application in DM. Therefore, the objectives of this review were to review the chemical composition of C. longa, the structure of curcumin, the degradation of curcumin, and the effects of curcumin derivatives on anti-diabetic properties against α-amylase and α-glucosidase enzymes. The results showed that C. longa contains carbohydrates, moisture, protein, fat, minerals, volatiles, fibre, and curcuminoids. Among the curcuminoids, curcumin is 60–70% present in C. longa. Moreover, curcumin and its derivatives have a lot of potential for treating DM, which was highlighted in this review. This review emphasises the several biological applications of curcumin, which collectively establish the foundation for its anti-diabetic characteristics. Considering these results, curcumin derivatives may be considered as potential agents in the pharmacotherapeutic management of patients with DM.
format Article
author Roney, Miah
Huq, A. K. M. Moyeenul
Rullah, Kamal
Normaiza, Zamri
Mohd Fadhlizil Fasihi, Mohd Aluwi
author_facet Roney, Miah
Huq, A. K. M. Moyeenul
Rullah, Kamal
Normaiza, Zamri
Mohd Fadhlizil Fasihi, Mohd Aluwi
author_sort Roney, Miah
title Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
title_short Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
title_full Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
title_fullStr Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
title_full_unstemmed Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
title_sort curcumin, a bioactive compound of turmeric (curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
publisher Springer
publishDate 2024
url http://umpir.ump.edu.my/id/eprint/42390/1/Curcumin%2C%20a%20bioactive%20compound%20of%20Turmeric%20%28Curcuma%20longa%29%20and%20its%20derivatives.pdf
http://umpir.ump.edu.my/id/eprint/42390/2/Curcumin%2C%20a%20bioactive%20compound%20of%20Turmeric%20%28Curcuma%20longa%29%20and%20its%20derivatives%20as%20%CE%B1-amylase%20and%20%CE%B1-glucosidase%20inhibitors.pdf
http://umpir.ump.edu.my/id/eprint/42390/
https://doi.org/10.1007/s12013-024-01477-5
_version_ 1822924617344352256
score 13.235362

Similar Items