Cover Image

Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh

The SARS-CoV-2 virus caused the COVID-19 pandemic and subsequent worldwide health issues because of the introduction of many subvariants, including Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, and Omicron (Sheeza et al. 2024). Every variation has its own unique set...

Full description

Saved in:
Bibliographic Details
Main Authors: Roney, Miah, Mohd Fadhlizil Fasihi, Mohd Aluwi
Format: Article
Language:English
Published: Springer Nature 2024
Subjects:
HD Industries. Land use. Labor
Q Science (General)
Online Access:http://umpir.ump.edu.my/id/eprint/42389/1/Evolution%20of%20SARS-CoV-2%20from%20BA.2.86%20to%20JN.1%20variations%20and%20detection%20in%20Bangladesh.pdf
http://umpir.ump.edu.my/id/eprint/42389/
https://doi.org/10.1186/s42269-024-01233-y
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.ump.umpir.42389
record_format eprints
spelling my.ump.umpir.423892024-08-18T08:04:56Z http://umpir.ump.edu.my/id/eprint/42389/ Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh Roney, Miah Mohd Fadhlizil Fasihi, Mohd Aluwi HD Industries. Land use. Labor Q Science (General) The SARS-CoV-2 virus caused the COVID-19 pandemic and subsequent worldwide health issues because of the introduction of many subvariants, including Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, and Omicron (Sheeza et al. 2024). Every variation has its own unique set of challenges. Moreover, the COVID-19 infection induces several cytokines, including TNF, IL-1β, and IL-6, as well as pro-inflammatory chemokines including CCL20, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL16 (Marlia et al. 2024). On the other hand, the SARS-CoV-2 saltation variation BA.2.86 has drawn attention across the world and was immediately identified as a variety under surveillance upon its appearance. BA.2.86 was first discovered in August 2023, is phylogenetically distinct from the circulating SARS-CoV-2 omicron XBB lineages, which include EG.5.1 and HK.3 (Satapathy et al. 2024). The spike protein of BA.2.86 has more than thirty mutations, it has a higher potential for immune evasion than XBB and BA.2. Furthermore, BA.2.86 showed a very high affinity for ACE2 binding but lacked a considerable growth advantage and humoral immune escape, when compared to current dominant variants like EG.5.1 and HK.3 (Yang et al. 2024). The development of BA.2.86 led to the appearance of JN.1 (BA.2.86.1.1) (Pirola) in late 2023 (Kaku et al. 2024; Satapathy et al. 2024). Therefore, natural immunity could be involved in warding off the illness. Herd immunity may be important if JN.1 spreads rapidly because some individuals have not yet gotten their vaccinations. Public awareness of social distance and other personal hygiene measures should also be reemphasized (Marlia et al. 2024). Springer Nature 2024 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/42389/1/Evolution%20of%20SARS-CoV-2%20from%20BA.2.86%20to%20JN.1%20variations%20and%20detection%20in%20Bangladesh.pdf Roney, Miah and Mohd Fadhlizil Fasihi, Mohd Aluwi (2024) Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh. Bulletin of the National Research Centre, 48 (78). pp. 1-7. ISSN 2522-8307. (Published) https://doi.org/10.1186/s42269-024-01233-y 10.1186/s42269-024-01233-y
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic HD Industries. Land use. Labor
Q Science (General)
spellingShingle HD Industries. Land use. Labor
Q Science (General)
Roney, Miah
Mohd Fadhlizil Fasihi, Mohd Aluwi
Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh
description The SARS-CoV-2 virus caused the COVID-19 pandemic and subsequent worldwide health issues because of the introduction of many subvariants, including Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, and Omicron (Sheeza et al. 2024). Every variation has its own unique set of challenges. Moreover, the COVID-19 infection induces several cytokines, including TNF, IL-1β, and IL-6, as well as pro-inflammatory chemokines including CCL20, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL16 (Marlia et al. 2024). On the other hand, the SARS-CoV-2 saltation variation BA.2.86 has drawn attention across the world and was immediately identified as a variety under surveillance upon its appearance. BA.2.86 was first discovered in August 2023, is phylogenetically distinct from the circulating SARS-CoV-2 omicron XBB lineages, which include EG.5.1 and HK.3 (Satapathy et al. 2024). The spike protein of BA.2.86 has more than thirty mutations, it has a higher potential for immune evasion than XBB and BA.2. Furthermore, BA.2.86 showed a very high affinity for ACE2 binding but lacked a considerable growth advantage and humoral immune escape, when compared to current dominant variants like EG.5.1 and HK.3 (Yang et al. 2024). The development of BA.2.86 led to the appearance of JN.1 (BA.2.86.1.1) (Pirola) in late 2023 (Kaku et al. 2024; Satapathy et al. 2024). Therefore, natural immunity could be involved in warding off the illness. Herd immunity may be important if JN.1 spreads rapidly because some individuals have not yet gotten their vaccinations. Public awareness of social distance and other personal hygiene measures should also be reemphasized (Marlia et al. 2024).
format Article
author Roney, Miah
Mohd Fadhlizil Fasihi, Mohd Aluwi
author_facet Roney, Miah
Mohd Fadhlizil Fasihi, Mohd Aluwi
author_sort Roney, Miah
title Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh
title_short Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh
title_full Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh
title_fullStr Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh
title_full_unstemmed Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh
title_sort evolution of sars-cov-2 from ba.2.86 to jn.1 variations and detection in bangladesh
publisher Springer Nature
publishDate 2024
url http://umpir.ump.edu.my/id/eprint/42389/1/Evolution%20of%20SARS-CoV-2%20from%20BA.2.86%20to%20JN.1%20variations%20and%20detection%20in%20Bangladesh.pdf
http://umpir.ump.edu.my/id/eprint/42389/
https://doi.org/10.1186/s42269-024-01233-y
_version_ 1822924617193357312
score 13.235362

Similar Items