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Filtration analysis of microparticles using paper-based microfluidics

A virus is a sub-microscopic infectious organism that causes diseases in humans, animals, and plants resulting in morbidity and may cause mortality. Proper diagnosis is necessary to initiate the treatment and pave the way to eradicate the viral infection. The current diagnostic kits for nucleic acid...

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Main Authors:	Bhuvaneshwari, K.S., Jeroish, Zachariah Ezhilnavaroji, Futane, Abhishek, Fahmi, Samsuri, Narayanamurthy, Vigneswaran
Format:	Article
Language:	English English
Published:	Springer 2024
Subjects:	T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering
Online Access:	http://umpir.ump.edu.my/id/eprint/42149/1/Filtration%20analysis%20of%20microparticles%20using%20paper-based%20microfluidics.pdf http://umpir.ump.edu.my/id/eprint/42149/2/Filtration%20analysis%20of%20microparticles%20using%20paper-based%20microfluidics_ABS.pdf http://umpir.ump.edu.my/id/eprint/42149/ https://doi.org/10.1007/s10337-024-04337-9 https://doi.org/10.1007/s10337-024-04337-9
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spelling	my.ump.umpir.421492024-09-30T04:51:07Z http://umpir.ump.edu.my/id/eprint/42149/ Filtration analysis of microparticles using paper-based microfluidics Bhuvaneshwari, K.S. Jeroish, Zachariah Ezhilnavaroji Futane, Abhishek Fahmi, Samsuri Narayanamurthy, Vigneswaran T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering A virus is a sub-microscopic infectious organism that causes diseases in humans, animals, and plants resulting in morbidity and may cause mortality. Proper diagnosis is necessary to initiate the treatment and pave the way to eradicate the viral infection. The current diagnostic kits for nucleic acid amplification assay, blood filtration, single-cell analysis are highly accurate, even though the procedure necessitates large sample volumes, complicated fabrication steps, time-consuming processes, and high costs. The filtration of viral samples from the blood is a tedious process. In this research, we have presented a home-based fabricated paper microfluidic chip to effectively filtrate viral particles from the sample to facilitate the nucleic acid amplification assay. The filtration analysis was exhibited for lateral and vertical flow paper chips fabricated via laser printing and polyethylene terephthalate (PET) encapsulation that circumvents the necessity of a traditional wax printer and hot plate. The results convey that the vertical flow paper chip with grade 4 inlet and outlet filters 98.57% of unnecessary particles from the sample. The paper-based microfluidic chip developed in this research is simple, easy to fabricate, and inexpensive to access in underdeveloped countries. The paper chip can pave the way for applications like lab-on-chip devices, POC assays, rapid nucleic acid amplification tests, cell cultures, and biomolecular research. Springer 2024 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42149/1/Filtration%20analysis%20of%20microparticles%20using%20paper-based%20microfluidics.pdf pdf en http://umpir.ump.edu.my/id/eprint/42149/2/Filtration%20analysis%20of%20microparticles%20using%20paper-based%20microfluidics_ABS.pdf Bhuvaneshwari, K.S. and Jeroish, Zachariah Ezhilnavaroji and Futane, Abhishek and Fahmi, Samsuri and Narayanamurthy, Vigneswaran (2024) Filtration analysis of microparticles using paper-based microfluidics. Chromatographia. pp. 1-11. ISSN 0009-5893. (In Press / Online First) (In Press / Online First) https://doi.org/10.1007/s10337-024-04337-9 https://doi.org/10.1007/s10337-024-04337-9
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
building	UMPSA Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Pahang Al-Sultan Abdullah
content_source	UMPSA Institutional Repository
url_provider	http://umpir.ump.edu.my/
language	English English
topic	T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering
spellingShingle	T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering Bhuvaneshwari, K.S. Jeroish, Zachariah Ezhilnavaroji Futane, Abhishek Fahmi, Samsuri Narayanamurthy, Vigneswaran Filtration analysis of microparticles using paper-based microfluidics
description	A virus is a sub-microscopic infectious organism that causes diseases in humans, animals, and plants resulting in morbidity and may cause mortality. Proper diagnosis is necessary to initiate the treatment and pave the way to eradicate the viral infection. The current diagnostic kits for nucleic acid amplification assay, blood filtration, single-cell analysis are highly accurate, even though the procedure necessitates large sample volumes, complicated fabrication steps, time-consuming processes, and high costs. The filtration of viral samples from the blood is a tedious process. In this research, we have presented a home-based fabricated paper microfluidic chip to effectively filtrate viral particles from the sample to facilitate the nucleic acid amplification assay. The filtration analysis was exhibited for lateral and vertical flow paper chips fabricated via laser printing and polyethylene terephthalate (PET) encapsulation that circumvents the necessity of a traditional wax printer and hot plate. The results convey that the vertical flow paper chip with grade 4 inlet and outlet filters 98.57% of unnecessary particles from the sample. The paper-based microfluidic chip developed in this research is simple, easy to fabricate, and inexpensive to access in underdeveloped countries. The paper chip can pave the way for applications like lab-on-chip devices, POC assays, rapid nucleic acid amplification tests, cell cultures, and biomolecular research.
format	Article
author	Bhuvaneshwari, K.S. Jeroish, Zachariah Ezhilnavaroji Futane, Abhishek Fahmi, Samsuri Narayanamurthy, Vigneswaran
author_facet	Bhuvaneshwari, K.S. Jeroish, Zachariah Ezhilnavaroji Futane, Abhishek Fahmi, Samsuri Narayanamurthy, Vigneswaran
author_sort	Bhuvaneshwari, K.S.
title	Filtration analysis of microparticles using paper-based microfluidics
title_short	Filtration analysis of microparticles using paper-based microfluidics
title_full	Filtration analysis of microparticles using paper-based microfluidics
title_fullStr	Filtration analysis of microparticles using paper-based microfluidics
title_full_unstemmed	Filtration analysis of microparticles using paper-based microfluidics
title_sort	filtration analysis of microparticles using paper-based microfluidics
publisher	Springer
publishDate	2024
url	http://umpir.ump.edu.my/id/eprint/42149/1/Filtration%20analysis%20of%20microparticles%20using%20paper-based%20microfluidics.pdf http://umpir.ump.edu.my/id/eprint/42149/2/Filtration%20analysis%20of%20microparticles%20using%20paper-based%20microfluidics_ABS.pdf http://umpir.ump.edu.my/id/eprint/42149/ https://doi.org/10.1007/s10337-024-04337-9 https://doi.org/10.1007/s10337-024-04337-9
_version_	1822924690262327296
score	13.23243

Filtration analysis of microparticles using paper-based microfluidics

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