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Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization

Carbamazepine-saccharin (CBZ-SAC) co-crystal is one of the most studied co-crystals to date. It is proven to be polymorphic, consisting of Form I (plate-like shape) and Form II (needle-like shape), which is rarely reported by researchers. The present study aimed to study the effect of SAC:CBZ ratio...

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Main Authors: Khairool Azizul, Mohammad, Wei, Michelle Ho Siaw, Engku Nuraishah Huda, Engku Zainudin, Syarifah, Abd Rahim
Format: Article
Language:English
English
Published: Springer Science and Business Media B.V. 2024
Subjects:
QD Chemistry
T Technology (General)
TA Engineering (General). Civil engineering (General)
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/42128/1/Impact%20of%20the%20SAC_CBZ%20ratio%20on%20polymorphic%20transformation.pdf
http://umpir.ump.edu.my/id/eprint/42128/2/Impact%20of%20the%20SAC_CBZ%20ratio%20on%20polymorphic%20transformation%20and%20morphology%20of%20carbamazepine-saccharin%20co-crystals%20using%20fast%20cooling%20crystallization_ABS.pdf
http://umpir.ump.edu.my/id/eprint/42128/
https://doi.org/10.1007/s10973-024-13379-y
https://doi.org/10.1007/s10973-024-13379-y
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spelling my.ump.umpir.421282024-09-30T04:50:01Z http://umpir.ump.edu.my/id/eprint/42128/ Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization Khairool Azizul, Mohammad Wei, Michelle Ho Siaw Engku Nuraishah Huda, Engku Zainudin Syarifah, Abd Rahim QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Carbamazepine-saccharin (CBZ-SAC) co-crystal is one of the most studied co-crystals to date. It is proven to be polymorphic, consisting of Form I (plate-like shape) and Form II (needle-like shape), which is rarely reported by researchers. The present study aimed to study the effect of SAC:CBZ ratio on the polymorphic transformation and morphology of CBZ-SAC co-crystals using ice bath fast cooling crystallization. A series of CBZ-SAC co-crystals were produced from different SAC:CBZ mol ratios (1:1, 2:1, 3:1, 4:1, 5:1, 6:1) and were compared in terms of their crystal form and morphology under microscope. The polymorphic changes were also studied from the CBZ-SAC suspension during co-crystallization process. The polymorphs of CBZ-SAC co-crystals were identified using PXRD, DSC, ATR-FTIR. The results showed that at lower ratio (1:1, 2:1, 3:1), only plate-like shaped crystals (Form I) was present. For higher mol ratio (4:1, 5:1, 6:1), mixture of Form I and II of CBZ-SAC co-crystals were observed and further confirmed by DSC and ATR-FTIR. The nucleation process showed that Form II could convert to Form I when varying the SAC:CBZ ratio. Hence, it is proven that SAC:CBZ mol ratio can affect the polymorphic transformation and morphology of CBZ-SAC co-crystals. Nonetheless, other parameters should be used to further study the formation of CBZ-SAC co-crystals since pure CBZ-SAC Form II co-crystals were not obtained in this study. Springer Science and Business Media B.V. 2024 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42128/1/Impact%20of%20the%20SAC_CBZ%20ratio%20on%20polymorphic%20transformation.pdf pdf en http://umpir.ump.edu.my/id/eprint/42128/2/Impact%20of%20the%20SAC_CBZ%20ratio%20on%20polymorphic%20transformation%20and%20morphology%20of%20carbamazepine-saccharin%20co-crystals%20using%20fast%20cooling%20crystallization_ABS.pdf Khairool Azizul, Mohammad and Wei, Michelle Ho Siaw and Engku Nuraishah Huda, Engku Zainudin and Syarifah, Abd Rahim (2024) Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization. Journal of Thermal Analysis and Calorimetry. pp. 1-13. ISSN 1388-6150. (In Press / Online First) (In Press / Online First) https://doi.org/10.1007/s10973-024-13379-y https://doi.org/10.1007/s10973-024-13379-y
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
English
topic QD Chemistry
T Technology (General)
TA Engineering (General). Civil engineering (General)
TP Chemical technology
spellingShingle QD Chemistry
T Technology (General)
TA Engineering (General). Civil engineering (General)
TP Chemical technology
Khairool Azizul, Mohammad
Wei, Michelle Ho Siaw
Engku Nuraishah Huda, Engku Zainudin
Syarifah, Abd Rahim
Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization
description Carbamazepine-saccharin (CBZ-SAC) co-crystal is one of the most studied co-crystals to date. It is proven to be polymorphic, consisting of Form I (plate-like shape) and Form II (needle-like shape), which is rarely reported by researchers. The present study aimed to study the effect of SAC:CBZ ratio on the polymorphic transformation and morphology of CBZ-SAC co-crystals using ice bath fast cooling crystallization. A series of CBZ-SAC co-crystals were produced from different SAC:CBZ mol ratios (1:1, 2:1, 3:1, 4:1, 5:1, 6:1) and were compared in terms of their crystal form and morphology under microscope. The polymorphic changes were also studied from the CBZ-SAC suspension during co-crystallization process. The polymorphs of CBZ-SAC co-crystals were identified using PXRD, DSC, ATR-FTIR. The results showed that at lower ratio (1:1, 2:1, 3:1), only plate-like shaped crystals (Form I) was present. For higher mol ratio (4:1, 5:1, 6:1), mixture of Form I and II of CBZ-SAC co-crystals were observed and further confirmed by DSC and ATR-FTIR. The nucleation process showed that Form II could convert to Form I when varying the SAC:CBZ ratio. Hence, it is proven that SAC:CBZ mol ratio can affect the polymorphic transformation and morphology of CBZ-SAC co-crystals. Nonetheless, other parameters should be used to further study the formation of CBZ-SAC co-crystals since pure CBZ-SAC Form II co-crystals were not obtained in this study.
format Article
author Khairool Azizul, Mohammad
Wei, Michelle Ho Siaw
Engku Nuraishah Huda, Engku Zainudin
Syarifah, Abd Rahim
author_facet Khairool Azizul, Mohammad
Wei, Michelle Ho Siaw
Engku Nuraishah Huda, Engku Zainudin
Syarifah, Abd Rahim
author_sort Khairool Azizul, Mohammad
title Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization
title_short Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization
title_full Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization
title_fullStr Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization
title_full_unstemmed Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization
title_sort impact of the sac : cbz ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization
publisher Springer Science and Business Media B.V.
publishDate 2024
url http://umpir.ump.edu.my/id/eprint/42128/1/Impact%20of%20the%20SAC_CBZ%20ratio%20on%20polymorphic%20transformation.pdf
http://umpir.ump.edu.my/id/eprint/42128/2/Impact%20of%20the%20SAC_CBZ%20ratio%20on%20polymorphic%20transformation%20and%20morphology%20of%20carbamazepine-saccharin%20co-crystals%20using%20fast%20cooling%20crystallization_ABS.pdf
http://umpir.ump.edu.my/id/eprint/42128/
https://doi.org/10.1007/s10973-024-13379-y
https://doi.org/10.1007/s10973-024-13379-y
_version_ 1822924688768106496
score 13.244413

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