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Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI

Sepsis-induced acute kidney injury (SAKI) patients are linked to high rates of death and morbidity. Additionally, infection and injury increase blood glucose levels, making glycemic control difficult. To control the glycemic level, insulin therapy is required to maintain blood glucose in a normal ra...

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Main Authors: Farhah, M., Fatanah, M. S., Mohd Zulfakar, M., Ummu Kulthum, Jamaludin, Normy, R., Syatirah, M. Z., Jihan, M. Z.N.
Format: Conference or Workshop Item
Language:English
English
Published: Institute of Electrical and Electronics Engineers Inc. 2022
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
Online Access:http://umpir.ump.edu.my/id/eprint/42104/1/Modeling%20of%20insulin%20sensitivity%20for%20Sepsis-AKI%20and%20Sepsis%20Non-AKI.pdf
http://umpir.ump.edu.my/id/eprint/42104/2/Modeling%20of%20insulin%20sensitivity%20for%20Sepsis-AKI%20and%20Sepsis%20Non-AKI_ABS.pdf
http://umpir.ump.edu.my/id/eprint/42104/
https://doi.org/10.1109/IECBES54088.2022.10079433
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spelling my.ump.umpir.421042024-09-30T04:46:22Z http://umpir.ump.edu.my/id/eprint/42104/ Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI Farhah, M. Fatanah, M. S. Mohd Zulfakar, M. Ummu Kulthum, Jamaludin Normy, R. Syatirah, M. Z. Jihan, M. Z.N. T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics Sepsis-induced acute kidney injury (SAKI) patients are linked to high rates of death and morbidity. Additionally, infection and injury increase blood glucose levels, making glycemic control difficult. To control the glycemic level, insulin therapy is required to maintain blood glucose in a normal range. Hence, this study intended to investigate the sepsis and AKI factors in blood glucose outcomes, especially for successful glycemic control. In this study, blood glucose level, insulin administration, and insulin sensitivity between sepsis-AKI And sepsis non-AKI were compared, along with the stochastic model of the two cohorts. Using retrospective clinical data of 20 ICU patients aged 18 years old and above from Hospital University Sains Malaysia from September to November 2021, 10 sepsis AKI patients spent longer total treatment hours (2526) and longer length of stay (median = 8 days) and had a higher median APACHE II score (median = 28) compared to sepsis non-AKI. Additionally, they had higher blood glucose levels per cohort (median = 9.8mmol/L) and higher insulin administration (median = 0.5 U/hr). However, the statistical analysis determined no significant difference between sepsis AKI and sepsis non-AKI in blood glucose level per cohort, per patient metrics, insulin sensitivity, and insulin dosage. In conclusion, it can be concluded that sepsis contributes much to reducing insulin sensitivity and thus plays an important role in affecting the blood glucose level. Clinical Relevance - This demonstrates that, despite AKI, sepsis had more impact on insulin sensitivity and plays an essential role in blood glucose outcome and the success of glycemic control. Institute of Electrical and Electronics Engineers Inc. 2022 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42104/1/Modeling%20of%20insulin%20sensitivity%20for%20Sepsis-AKI%20and%20Sepsis%20Non-AKI.pdf pdf en http://umpir.ump.edu.my/id/eprint/42104/2/Modeling%20of%20insulin%20sensitivity%20for%20Sepsis-AKI%20and%20Sepsis%20Non-AKI_ABS.pdf Farhah, M. and Fatanah, M. S. and Mohd Zulfakar, M. and Ummu Kulthum, Jamaludin and Normy, R. and Syatirah, M. Z. and Jihan, M. Z.N. (2022) Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI. In: 7th IEEE-EMBS Conference on Biomedical Engineering and Sciences, IECBES 2022 - Proceedings. 7th IEEE-EMBS Conference on Biomedical Engineering and Sciences, IECBES 2022 , 7 - 9 December 2022 , Virtual, Online. pp. 223-227.. ISBN 978-166549469-4 (Published) https://doi.org/10.1109/IECBES54088.2022.10079433
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
Farhah, M.
Fatanah, M. S.
Mohd Zulfakar, M.
Ummu Kulthum, Jamaludin
Normy, R.
Syatirah, M. Z.
Jihan, M. Z.N.
Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI
description Sepsis-induced acute kidney injury (SAKI) patients are linked to high rates of death and morbidity. Additionally, infection and injury increase blood glucose levels, making glycemic control difficult. To control the glycemic level, insulin therapy is required to maintain blood glucose in a normal range. Hence, this study intended to investigate the sepsis and AKI factors in blood glucose outcomes, especially for successful glycemic control. In this study, blood glucose level, insulin administration, and insulin sensitivity between sepsis-AKI And sepsis non-AKI were compared, along with the stochastic model of the two cohorts. Using retrospective clinical data of 20 ICU patients aged 18 years old and above from Hospital University Sains Malaysia from September to November 2021, 10 sepsis AKI patients spent longer total treatment hours (2526) and longer length of stay (median = 8 days) and had a higher median APACHE II score (median = 28) compared to sepsis non-AKI. Additionally, they had higher blood glucose levels per cohort (median = 9.8mmol/L) and higher insulin administration (median = 0.5 U/hr). However, the statistical analysis determined no significant difference between sepsis AKI and sepsis non-AKI in blood glucose level per cohort, per patient metrics, insulin sensitivity, and insulin dosage. In conclusion, it can be concluded that sepsis contributes much to reducing insulin sensitivity and thus plays an important role in affecting the blood glucose level. Clinical Relevance - This demonstrates that, despite AKI, sepsis had more impact on insulin sensitivity and plays an essential role in blood glucose outcome and the success of glycemic control.
format Conference or Workshop Item
author Farhah, M.
Fatanah, M. S.
Mohd Zulfakar, M.
Ummu Kulthum, Jamaludin
Normy, R.
Syatirah, M. Z.
Jihan, M. Z.N.
author_facet Farhah, M.
Fatanah, M. S.
Mohd Zulfakar, M.
Ummu Kulthum, Jamaludin
Normy, R.
Syatirah, M. Z.
Jihan, M. Z.N.
author_sort Farhah, M.
title Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI
title_short Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI
title_full Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI
title_fullStr Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI
title_full_unstemmed Modeling of insulin sensitivity for Sepsis-AKI and Sepsis Non-AKI
title_sort modeling of insulin sensitivity for sepsis-aki and sepsis non-aki
publisher Institute of Electrical and Electronics Engineers Inc.
publishDate 2022
url http://umpir.ump.edu.my/id/eprint/42104/1/Modeling%20of%20insulin%20sensitivity%20for%20Sepsis-AKI%20and%20Sepsis%20Non-AKI.pdf
http://umpir.ump.edu.my/id/eprint/42104/2/Modeling%20of%20insulin%20sensitivity%20for%20Sepsis-AKI%20and%20Sepsis%20Non-AKI_ABS.pdf
http://umpir.ump.edu.my/id/eprint/42104/
https://doi.org/10.1109/IECBES54088.2022.10079433
_version_ 1822924685475577856
score 13.23648

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