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Brain capillary geometry development for multiscale modelling study

Due to low spatial resolution of functional magnetic resonance imaging (fMRI), mathematical modelling of human brain is usually developed in ischaemic stroke study in order to enhance the understanding of ischaemic stroke mechanism so that proper treatment plan can be decided to a particular stroke...

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Main Authors: Shabudin, Abbas, Maryah Harzarina, Jasni, Mohd Jamil, Mohamed Mokhtarudin
Format: Conference or Workshop Item
Language:English
English
Published: IET 2022
Subjects:
TJ Mechanical engineering and machinery
TS Manufactures
Online Access:http://umpir.ump.edu.my/id/eprint/41958/1/Brain%20capillary%20geometry%20development%20for%20multiscale%20modelling%20study_ABST.pdf
http://umpir.ump.edu.my/id/eprint/41958/2/Brain%20capillary%20geometry%20development%20for%20multiscale%20modelling%20study.pdf
http://umpir.ump.edu.my/id/eprint/41958/
https://doi.org/10.1049/icp.2022.2563
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spelling my.ump.umpir.419582024-07-16T07:33:53Z http://umpir.ump.edu.my/id/eprint/41958/ Brain capillary geometry development for multiscale modelling study Shabudin, Abbas Maryah Harzarina, Jasni Mohd Jamil, Mohamed Mokhtarudin TJ Mechanical engineering and machinery TS Manufactures Due to low spatial resolution of functional magnetic resonance imaging (fMRI), mathematical modelling of human brain is usually developed in ischaemic stroke study in order to enhance the understanding of ischaemic stroke mechanism so that proper treatment plan can be decided to a particular stroke patient. A 3D brain geometry is developed in this project using AutoLISP, which is a programming language within AutoCAD. The objective of this project is to re-create the geometry developed by El-Bouri et al. by replacing the 1-dimensional line with 3-dimensional capillary which can be meshed for the simulation. Simulation of blood flow using Stokes' cell equation is done in the 3D geometry in order to obtain effective hydraulic conductivity, K. Finally, the hydraulic conductivity obtained from the simulation is analysed and compared with previous work done by El-Bouri et al. Based on result in section 3, the initial geometry developed is further modified by adding few small cylinders and also bigger volume of the geometry with 15.21% percentage difference. Non-diagonal elements obtained in matrix K show non-zero values due to small voxel size used for the simulation (180µm), which should be increased to more than 250µm. The percentage difference of diagonal elements K 11 , K 22 , and K 33 are 8.05%, 2.65% and 21.43% respectively. The large percentage differences are probably due to additional volume added to the 3D geometry to maintain its periodicity with neighbouring voxels. Besides, meshing process and mesh size chosen are also contributing factor to the large percentage difference between both hydraulic conductivity values. IET 2022 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41958/1/Brain%20capillary%20geometry%20development%20for%20multiscale%20modelling%20study_ABST.pdf pdf en http://umpir.ump.edu.my/id/eprint/41958/2/Brain%20capillary%20geometry%20development%20for%20multiscale%20modelling%20study.pdf Shabudin, Abbas and Maryah Harzarina, Jasni and Mohd Jamil, Mohamed Mokhtarudin (2022) Brain capillary geometry development for multiscale modelling study. In: IET Conference Proceedings. IET Conference Proceedings; 2022 Engineering Technology International Conference, ETIC 2022 , 07 - 08 September 2022 , Pahang, Virtual. 26 -30., 2022 (22). ISSN 2732-4494 ISBN 978-183953782-0 https://doi.org/10.1049/icp.2022.2563
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
English
topic TJ Mechanical engineering and machinery
TS Manufactures
spellingShingle TJ Mechanical engineering and machinery
TS Manufactures
Shabudin, Abbas
Maryah Harzarina, Jasni
Mohd Jamil, Mohamed Mokhtarudin
Brain capillary geometry development for multiscale modelling study
description Due to low spatial resolution of functional magnetic resonance imaging (fMRI), mathematical modelling of human brain is usually developed in ischaemic stroke study in order to enhance the understanding of ischaemic stroke mechanism so that proper treatment plan can be decided to a particular stroke patient. A 3D brain geometry is developed in this project using AutoLISP, which is a programming language within AutoCAD. The objective of this project is to re-create the geometry developed by El-Bouri et al. by replacing the 1-dimensional line with 3-dimensional capillary which can be meshed for the simulation. Simulation of blood flow using Stokes' cell equation is done in the 3D geometry in order to obtain effective hydraulic conductivity, K. Finally, the hydraulic conductivity obtained from the simulation is analysed and compared with previous work done by El-Bouri et al. Based on result in section 3, the initial geometry developed is further modified by adding few small cylinders and also bigger volume of the geometry with 15.21% percentage difference. Non-diagonal elements obtained in matrix K show non-zero values due to small voxel size used for the simulation (180µm), which should be increased to more than 250µm. The percentage difference of diagonal elements K 11 , K 22 , and K 33 are 8.05%, 2.65% and 21.43% respectively. The large percentage differences are probably due to additional volume added to the 3D geometry to maintain its periodicity with neighbouring voxels. Besides, meshing process and mesh size chosen are also contributing factor to the large percentage difference between both hydraulic conductivity values.
format Conference or Workshop Item
author Shabudin, Abbas
Maryah Harzarina, Jasni
Mohd Jamil, Mohamed Mokhtarudin
author_facet Shabudin, Abbas
Maryah Harzarina, Jasni
Mohd Jamil, Mohamed Mokhtarudin
author_sort Shabudin, Abbas
title Brain capillary geometry development for multiscale modelling study
title_short Brain capillary geometry development for multiscale modelling study
title_full Brain capillary geometry development for multiscale modelling study
title_fullStr Brain capillary geometry development for multiscale modelling study
title_full_unstemmed Brain capillary geometry development for multiscale modelling study
title_sort brain capillary geometry development for multiscale modelling study
publisher IET
publishDate 2022
url http://umpir.ump.edu.my/id/eprint/41958/1/Brain%20capillary%20geometry%20development%20for%20multiscale%20modelling%20study_ABST.pdf
http://umpir.ump.edu.my/id/eprint/41958/2/Brain%20capillary%20geometry%20development%20for%20multiscale%20modelling%20study.pdf
http://umpir.ump.edu.my/id/eprint/41958/
https://doi.org/10.1049/icp.2022.2563
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score 13.232492

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