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Modelling the effect of ischemia on myocardial electrophysiology

Myocardial infarction (MI), also known as a heart attack is one of the lifelong chronic diseases that can give a permanent damage to the heart muscle. This creates a disruption of oxygen supply to the myocardium that could lead to arrhythmia. However, the underlying mechanism that relate MI and arrh...

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Main Authors: P. N. A. Nasuha, Mohd Nor, Mohd Jamil, Mohamed Mokhtarudin
Format: Conference or Workshop Item
Language:English
Published: IET 2022
Subjects:
TJ Mechanical engineering and machinery
TS Manufactures
Online Access:http://umpir.ump.edu.my/id/eprint/41954/1/Modelling%20the%20effect%20of%20ischemia%20on%20myocardial%20electrophysiology.pdf
http://umpir.ump.edu.my/id/eprint/41954/
https://doi.org/10.1049/icp.2022.2671
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spelling my.ump.umpir.419542024-07-16T05:00:04Z http://umpir.ump.edu.my/id/eprint/41954/ Modelling the effect of ischemia on myocardial electrophysiology P. N. A. Nasuha, Mohd Nor Mohd Jamil, Mohamed Mokhtarudin TJ Mechanical engineering and machinery TS Manufactures Myocardial infarction (MI), also known as a heart attack is one of the lifelong chronic diseases that can give a permanent damage to the heart muscle. This creates a disruption of oxygen supply to the myocardium that could lead to arrhythmia. However, the underlying mechanism that relate MI and arrhythmia is difficult to be described. In this study, a mathematical model to investigate the relationship between MI and arrhythmia is developed using the oxygen diffusion model coupled with the myocardium electrophysiological model based on the work by Ten Tusscher et al. Four levels of ischemia are simulated by modifying the initial oxygen percentage, which are reduced by 10%, 40%, 50%, and 90%. From the simulations, the myocardium electrophysiology is affected by the reduction of oxygen and validated some of the findings from previous clinical works. It is also found that a larger oxygen reduction within the myocardium causes overload of intracellular sodium and calcium ions, which has been previously studied that this could potentially give higher risk of myocardial injury. In addition, oxygen reduction in myocardium causes changes in the morphology of the action potential, which could initiate arrhythmia post-ischemia. IET 2022 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41954/1/Modelling%20the%20effect%20of%20ischemia%20on%20myocardial%20electrophysiology.pdf P. N. A. Nasuha, Mohd Nor and Mohd Jamil, Mohamed Mokhtarudin (2022) Modelling the effect of ischemia on myocardial electrophysiology. In: IET Conference Proceedings. IET Conference Proceedings; 2022 Engineering Technology International Conference, ETIC 2022 , 07 - 08 September 2022 , Pahang, Virtual. 498 -503., 2022 (22). ISSN 2732-4494 ISBN 978-183953782-0 https://doi.org/10.1049/icp.2022.2671
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TJ Mechanical engineering and machinery
TS Manufactures
spellingShingle TJ Mechanical engineering and machinery
TS Manufactures
P. N. A. Nasuha, Mohd Nor
Mohd Jamil, Mohamed Mokhtarudin
Modelling the effect of ischemia on myocardial electrophysiology
description Myocardial infarction (MI), also known as a heart attack is one of the lifelong chronic diseases that can give a permanent damage to the heart muscle. This creates a disruption of oxygen supply to the myocardium that could lead to arrhythmia. However, the underlying mechanism that relate MI and arrhythmia is difficult to be described. In this study, a mathematical model to investigate the relationship between MI and arrhythmia is developed using the oxygen diffusion model coupled with the myocardium electrophysiological model based on the work by Ten Tusscher et al. Four levels of ischemia are simulated by modifying the initial oxygen percentage, which are reduced by 10%, 40%, 50%, and 90%. From the simulations, the myocardium electrophysiology is affected by the reduction of oxygen and validated some of the findings from previous clinical works. It is also found that a larger oxygen reduction within the myocardium causes overload of intracellular sodium and calcium ions, which has been previously studied that this could potentially give higher risk of myocardial injury. In addition, oxygen reduction in myocardium causes changes in the morphology of the action potential, which could initiate arrhythmia post-ischemia.
format Conference or Workshop Item
author P. N. A. Nasuha, Mohd Nor
Mohd Jamil, Mohamed Mokhtarudin
author_facet P. N. A. Nasuha, Mohd Nor
Mohd Jamil, Mohamed Mokhtarudin
author_sort P. N. A. Nasuha, Mohd Nor
title Modelling the effect of ischemia on myocardial electrophysiology
title_short Modelling the effect of ischemia on myocardial electrophysiology
title_full Modelling the effect of ischemia on myocardial electrophysiology
title_fullStr Modelling the effect of ischemia on myocardial electrophysiology
title_full_unstemmed Modelling the effect of ischemia on myocardial electrophysiology
title_sort modelling the effect of ischemia on myocardial electrophysiology
publisher IET
publishDate 2022
url http://umpir.ump.edu.my/id/eprint/41954/1/Modelling%20the%20effect%20of%20ischemia%20on%20myocardial%20electrophysiology.pdf
http://umpir.ump.edu.my/id/eprint/41954/
https://doi.org/10.1049/icp.2022.2671
_version_ 1822924482182905856
score 13.235362

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