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Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method

Oral administration of drugs is preferred over other routes for several reasons: it is non-invasive, easy to administer, and easy to store. However, drug formulation for oral administration is often hindered by the drug's poor solubility, which limits its bioavailability and reduces its commerc...

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Main Authors:	AL-japairai, Khater Ahmed Saeed, Almurisi, Samah Hamed, Syed, Mahmood, Madheswaran, Thiagarajan, Chatterjee, Bappaditya, Sri, Prasanthi, Nadiatul Azra, Ahmad Mazlan, Al Hagbani, Turki, Alheibshy, Fawaz
Format:	Article
Language:	English English
Published:	Elsevier B.V. 2023
Subjects:	QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/41800/1/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions.pdf http://umpir.ump.edu.my/id/eprint/41800/2/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions%20in%20view%20of%20the%20hot%20melt%20extrusion%20%28HME%29%20method_ABS.pdf http://umpir.ump.edu.my/id/eprint/41800/ https://doi.org/10.1016/j.ijpharm.2023.123536 https://doi.org/10.1016/j.ijpharm.2023.123536
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spelling	my.ump.umpir.418002024-08-30T00:05:51Z http://umpir.ump.edu.my/id/eprint/41800/ Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method AL-japairai, Khater Ahmed Saeed Almurisi, Samah Hamed Syed, Mahmood Madheswaran, Thiagarajan Chatterjee, Bappaditya Sri, Prasanthi Nadiatul Azra, Ahmad Mazlan Al Hagbani, Turki Alheibshy, Fawaz QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Oral administration of drugs is preferred over other routes for several reasons: it is non-invasive, easy to administer, and easy to store. However, drug formulation for oral administration is often hindered by the drug's poor solubility, which limits its bioavailability and reduces its commercial value. As a solution, amorphous solid dispersion (ASD) was introduced as a drug formulation method that improves drug solubility by changing the molecular structure of the drugs from crystalline to amorphous. The hot melt extrusion (HME) method is emerging in the pharmaceutical industry as an alternative to manufacture ASD. However, despite solving solubility issues, ASD also exposes the drug to a high risk of crystallisation, either during processing or storage. Formulating a successful oral administration drug using ASD requires optimisation of the formulation, polymers, and HME manufacturing processes applied. This review presents some important considerations in ASD formulation, including strategies to improve the stability of the final product using HME to allow more new drugs to be formulated using this method. Elsevier B.V. 2023-11-25 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41800/1/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions.pdf pdf en http://umpir.ump.edu.my/id/eprint/41800/2/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions%20in%20view%20of%20the%20hot%20melt%20extrusion%20%28HME%29%20method_ABS.pdf AL-japairai, Khater Ahmed Saeed and Almurisi, Samah Hamed and Syed, Mahmood and Madheswaran, Thiagarajan and Chatterjee, Bappaditya and Sri, Prasanthi and Nadiatul Azra, Ahmad Mazlan and Al Hagbani, Turki and Alheibshy, Fawaz (2023) Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method. International Journal of Pharmaceutics, 647 (123536). pp. 1-13. ISSN 0378-5173. (Published) https://doi.org/10.1016/j.ijpharm.2023.123536 https://doi.org/10.1016/j.ijpharm.2023.123536
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
building	UMPSA Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Pahang Al-Sultan Abdullah
content_source	UMPSA Institutional Repository
url_provider	http://umpir.ump.edu.my/
language	English English
topic	QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology
spellingShingle	QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology AL-japairai, Khater Ahmed Saeed Almurisi, Samah Hamed Syed, Mahmood Madheswaran, Thiagarajan Chatterjee, Bappaditya Sri, Prasanthi Nadiatul Azra, Ahmad Mazlan Al Hagbani, Turki Alheibshy, Fawaz Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
description	Oral administration of drugs is preferred over other routes for several reasons: it is non-invasive, easy to administer, and easy to store. However, drug formulation for oral administration is often hindered by the drug's poor solubility, which limits its bioavailability and reduces its commercial value. As a solution, amorphous solid dispersion (ASD) was introduced as a drug formulation method that improves drug solubility by changing the molecular structure of the drugs from crystalline to amorphous. The hot melt extrusion (HME) method is emerging in the pharmaceutical industry as an alternative to manufacture ASD. However, despite solving solubility issues, ASD also exposes the drug to a high risk of crystallisation, either during processing or storage. Formulating a successful oral administration drug using ASD requires optimisation of the formulation, polymers, and HME manufacturing processes applied. This review presents some important considerations in ASD formulation, including strategies to improve the stability of the final product using HME to allow more new drugs to be formulated using this method.
format	Article
author	AL-japairai, Khater Ahmed Saeed Almurisi, Samah Hamed Syed, Mahmood Madheswaran, Thiagarajan Chatterjee, Bappaditya Sri, Prasanthi Nadiatul Azra, Ahmad Mazlan Al Hagbani, Turki Alheibshy, Fawaz
author_facet	AL-japairai, Khater Ahmed Saeed Almurisi, Samah Hamed Syed, Mahmood Madheswaran, Thiagarajan Chatterjee, Bappaditya Sri, Prasanthi Nadiatul Azra, Ahmad Mazlan Al Hagbani, Turki Alheibshy, Fawaz
author_sort	AL-japairai, Khater Ahmed Saeed
title	Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
title_short	Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
title_full	Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
title_fullStr	Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
title_full_unstemmed	Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
title_sort	strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (hme) method
publisher	Elsevier B.V.
publishDate	2023
url	http://umpir.ump.edu.my/id/eprint/41800/1/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions.pdf http://umpir.ump.edu.my/id/eprint/41800/2/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions%20in%20view%20of%20the%20hot%20melt%20extrusion%20%28HME%29%20method_ABS.pdf http://umpir.ump.edu.my/id/eprint/41800/ https://doi.org/10.1016/j.ijpharm.2023.123536 https://doi.org/10.1016/j.ijpharm.2023.123536
_version_	1822924589542408192
score	13.235796

Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method

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