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Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model

This project aims to investigate the effects of capillary size and shape toward the brain tissue poroelastic properties model using asymptotic expansion homogenization (AEH). Applying AEH to the existing poroelastic governing equations (GE) results in a new GE consists of 6 macroscale equations and...

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Main Authors:	Abbas, Shabudin, Mohd Jamil, Mohamed Mokhtarudin, Payne, Stephen J., Wan Naimah, Wan Ab Naim, Nik Abdullah, Nik Mohamed
Format:	Conference or Workshop Item
Language:	English English
Published:	Springer 2023
Subjects:	TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics
Online Access:	http://umpir.ump.edu.my/id/eprint/41780/1/Multiscale%20Modelling%20of%203-Dimensional%20Brain%20Tissue.pdf http://umpir.ump.edu.my/id/eprint/41780/2/Multiscale%20Modelling%20of%203-Dimensional%20Brain%20Tissue%20Using%20Ideal%20Capillary%20Model.pdf http://umpir.ump.edu.my/id/eprint/41780/ https://doi.org/10.1007/978-981-19-4425-3_19
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spelling	my.ump.umpir.417802024-07-02T08:12:58Z http://umpir.ump.edu.my/id/eprint/41780/ Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model Abbas, Shabudin Mohd Jamil, Mohamed Mokhtarudin Payne, Stephen J. Wan Naimah, Wan Ab Naim Nik Abdullah, Nik Mohamed TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics This project aims to investigate the effects of capillary size and shape toward the brain tissue poroelastic properties model using asymptotic expansion homogenization (AEH). Applying AEH to the existing poroelastic governing equations (GE) results in a new GE consists of 6 macroscale equations and 4 microscale cell problems. The cell problems are solved on a microstructure geometry of brain tissue with capillary embedded to obtain effective parametric tensors, namely the capillary and interstitial hydraulic conductivity (K and G ), capillary and interstitial homogenous Biot’s coefficient (αc and αt ), Young’s modulus (E) and Poisson’s ratio (v). By varying the tortuosity, the percentage difference of K is 97.98%, shows that it is highly affected by tortuosity. The percentage difference of G is 0.25% implying that tortuosity insignificantly affecting G. Meanwhile, αc and αt decreases and increases with tortuosity, respectively. The percentage difference of E and v are 0.14% and 0.03% respectively, implying that both parameters does not affected by tortuosity. Besides, K is exponentially increases with the increase of radius. On the other hand, G decreases as the radius increases. Meanwhile αc and αt increases and decreases, respectively as radius increases. The percentage differences of E and v are 18.26% and 14.55% respectively, suggesting that they are significantly affected by the radius. In conclusion, capillary shape and size have significant impact on the simulation of human brain. Thus, both characteristics should be precisely emphasized in the development of the geometry so that accurate parameters can be obtained to solve macroscale equations in future. Springer 2023 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41780/1/Multiscale%20Modelling%20of%203-Dimensional%20Brain%20Tissue.pdf pdf en http://umpir.ump.edu.my/id/eprint/41780/2/Multiscale%20Modelling%20of%203-Dimensional%20Brain%20Tissue%20Using%20Ideal%20Capillary%20Model.pdf Abbas, Shabudin and Mohd Jamil, Mohamed Mokhtarudin and Payne, Stephen J. and Wan Naimah, Wan Ab Naim and Nik Abdullah, Nik Mohamed (2023) Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model. In: Proceedings of the 2nd Energy Security and Chemical Engineering Congress. Lecture Notes in Mechanical Engineering. 2nd Energy Security and Chemical Engineering Congress (ESChE 2021) , 3-5 November 2021 , Universiti Malaysia Pahang (Virtual Conference). pp. 205-221.. ISSN 2195-4356 ISBN 978-981-19-4424-6 https://doi.org/10.1007/978-981-19-4425-3_19
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
building	UMPSA Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Pahang Al-Sultan Abdullah
content_source	UMPSA Institutional Repository
url_provider	http://umpir.ump.edu.my/
language	English English
topic	TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics
spellingShingle	TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics Abbas, Shabudin Mohd Jamil, Mohamed Mokhtarudin Payne, Stephen J. Wan Naimah, Wan Ab Naim Nik Abdullah, Nik Mohamed Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model
description	This project aims to investigate the effects of capillary size and shape toward the brain tissue poroelastic properties model using asymptotic expansion homogenization (AEH). Applying AEH to the existing poroelastic governing equations (GE) results in a new GE consists of 6 macroscale equations and 4 microscale cell problems. The cell problems are solved on a microstructure geometry of brain tissue with capillary embedded to obtain effective parametric tensors, namely the capillary and interstitial hydraulic conductivity (K and G ), capillary and interstitial homogenous Biot’s coefficient (αc and αt ), Young’s modulus (E) and Poisson’s ratio (v). By varying the tortuosity, the percentage difference of K is 97.98%, shows that it is highly affected by tortuosity. The percentage difference of G is 0.25% implying that tortuosity insignificantly affecting G. Meanwhile, αc and αt decreases and increases with tortuosity, respectively. The percentage difference of E and v are 0.14% and 0.03% respectively, implying that both parameters does not affected by tortuosity. Besides, K is exponentially increases with the increase of radius. On the other hand, G decreases as the radius increases. Meanwhile αc and αt increases and decreases, respectively as radius increases. The percentage differences of E and v are 18.26% and 14.55% respectively, suggesting that they are significantly affected by the radius. In conclusion, capillary shape and size have significant impact on the simulation of human brain. Thus, both characteristics should be precisely emphasized in the development of the geometry so that accurate parameters can be obtained to solve macroscale equations in future.
format	Conference or Workshop Item
author	Abbas, Shabudin Mohd Jamil, Mohamed Mokhtarudin Payne, Stephen J. Wan Naimah, Wan Ab Naim Nik Abdullah, Nik Mohamed
author_facet	Abbas, Shabudin Mohd Jamil, Mohamed Mokhtarudin Payne, Stephen J. Wan Naimah, Wan Ab Naim Nik Abdullah, Nik Mohamed
author_sort	Abbas, Shabudin
title	Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model
title_short	Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model
title_full	Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model
title_fullStr	Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model
title_full_unstemmed	Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model
title_sort	multiscale modelling of 3-dimensional brain tissue using ideal capillary model
publisher	Springer
publishDate	2023
url	http://umpir.ump.edu.my/id/eprint/41780/1/Multiscale%20Modelling%20of%203-Dimensional%20Brain%20Tissue.pdf http://umpir.ump.edu.my/id/eprint/41780/2/Multiscale%20Modelling%20of%203-Dimensional%20Brain%20Tissue%20Using%20Ideal%20Capillary%20Model.pdf http://umpir.ump.edu.my/id/eprint/41780/ https://doi.org/10.1007/978-981-19-4425-3_19
_version_	1822924448444973056
score	13.235318

Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model

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