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Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system

Magnetic nanoparticles (MNPs) have been studied for various medical applications by taking advantage of their unique magnetic properties. Magnetic immunoassay (MIA) is a technique for the rapid detection of target biomarkers by antigen-antibody reaction between antibody-modified MNPs and the target...

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Main Authors: Yamashita, Kei, Kishimoto, Kouhei, Kuroda, Hiroto, Wang, Jin, Sakai, Kenji, Mohd Mawardi, Saari, Kiwa, Toshihiko
Format: Article
Language:English
English
Published: Institute of Electrical and Electronics Engineers Inc. 2023
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
TK Electrical engineering. Electronics Nuclear engineering
Online Access:http://umpir.ump.edu.my/id/eprint/40842/1/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents.pdf
http://umpir.ump.edu.my/id/eprint/40842/2/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents%20evaluated%20by%20HTS-SQUID%20magnetic%20immunoassay%20system_ABS.pdf
http://umpir.ump.edu.my/id/eprint/40842/
https://doi.org/10.1109/TASC.2023.3239830
https://doi.org/10.1109/TASC.2023.3239830
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spelling my.ump.umpir.408422024-05-28T08:04:01Z http://umpir.ump.edu.my/id/eprint/40842/ Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system Yamashita, Kei Kishimoto, Kouhei Kuroda, Hiroto Wang, Jin Sakai, Kenji Mohd Mawardi, Saari Kiwa, Toshihiko T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering Magnetic nanoparticles (MNPs) have been studied for various medical applications by taking advantage of their unique magnetic properties. Magnetic immunoassay (MIA) is a technique for the rapid detection of target biomarkers by antigen-antibody reaction between antibody-modified MNPs and the target biomarker. In this study, we aim to improve the accuracy of the MIA, we evaluated the AC magnetic properties of MNPs in the biological solvents. To measure the magnetic signal of MNPs, we used the developed HTS-SQUID magnetic immunoassay system. First, we evaluated the instability of the HTS-SQUID magnetic immunoassay system using pellets of manganese (II) fluoride. The results show that the device instability due to operating time does not affect the measurement of magnetic signal changes in MNPs due to biological solvents. Since the magnetic properties of MNPs depend on particle size and viscosity, we measured the time evolution of the magnetic signal of Resovist in glycerin, human serum, sheep whole blood, and NaCl. It was found that the magnetic signal of Resovist decreased exponentially with ions contained in the solvent. The results are fitted as the exponential double function, suggesting that the magnetic signal of MNPs in biological solvents is affected by the aggregation of MNPs in the blood and that there are at least two steps in the mechanism of the aggregation. Institute of Electrical and Electronics Engineers Inc. 2023-08-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/40842/1/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents.pdf pdf en http://umpir.ump.edu.my/id/eprint/40842/2/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents%20evaluated%20by%20HTS-SQUID%20magnetic%20immunoassay%20system_ABS.pdf Yamashita, Kei and Kishimoto, Kouhei and Kuroda, Hiroto and Wang, Jin and Sakai, Kenji and Mohd Mawardi, Saari and Kiwa, Toshihiko (2023) Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system. IEEE Transactions on Applied Superconductivity, 33 (1600405). pp. 1-5. ISSN 1051-8223. (Published) https://doi.org/10.1109/TASC.2023.3239830 https://doi.org/10.1109/TASC.2023.3239830
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
TK Electrical engineering. Electronics Nuclear engineering
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
TK Electrical engineering. Electronics Nuclear engineering
Yamashita, Kei
Kishimoto, Kouhei
Kuroda, Hiroto
Wang, Jin
Sakai, Kenji
Mohd Mawardi, Saari
Kiwa, Toshihiko
Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system
description Magnetic nanoparticles (MNPs) have been studied for various medical applications by taking advantage of their unique magnetic properties. Magnetic immunoassay (MIA) is a technique for the rapid detection of target biomarkers by antigen-antibody reaction between antibody-modified MNPs and the target biomarker. In this study, we aim to improve the accuracy of the MIA, we evaluated the AC magnetic properties of MNPs in the biological solvents. To measure the magnetic signal of MNPs, we used the developed HTS-SQUID magnetic immunoassay system. First, we evaluated the instability of the HTS-SQUID magnetic immunoassay system using pellets of manganese (II) fluoride. The results show that the device instability due to operating time does not affect the measurement of magnetic signal changes in MNPs due to biological solvents. Since the magnetic properties of MNPs depend on particle size and viscosity, we measured the time evolution of the magnetic signal of Resovist in glycerin, human serum, sheep whole blood, and NaCl. It was found that the magnetic signal of Resovist decreased exponentially with ions contained in the solvent. The results are fitted as the exponential double function, suggesting that the magnetic signal of MNPs in biological solvents is affected by the aggregation of MNPs in the blood and that there are at least two steps in the mechanism of the aggregation.
format Article
author Yamashita, Kei
Kishimoto, Kouhei
Kuroda, Hiroto
Wang, Jin
Sakai, Kenji
Mohd Mawardi, Saari
Kiwa, Toshihiko
author_facet Yamashita, Kei
Kishimoto, Kouhei
Kuroda, Hiroto
Wang, Jin
Sakai, Kenji
Mohd Mawardi, Saari
Kiwa, Toshihiko
author_sort Yamashita, Kei
title Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system
title_short Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system
title_full Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system
title_fullStr Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system
title_full_unstemmed Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system
title_sort aggregation of magnetic nanoparticles in biological solvents evaluated by hts-squid magnetic immunoassay system
publisher Institute of Electrical and Electronics Engineers Inc.
publishDate 2023
url http://umpir.ump.edu.my/id/eprint/40842/1/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents.pdf
http://umpir.ump.edu.my/id/eprint/40842/2/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents%20evaluated%20by%20HTS-SQUID%20magnetic%20immunoassay%20system_ABS.pdf
http://umpir.ump.edu.my/id/eprint/40842/
https://doi.org/10.1109/TASC.2023.3239830
https://doi.org/10.1109/TASC.2023.3239830
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score 13.232414

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