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Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica

This study aims to investigate the influence of agitation and solvent percentage on the phytochemical extraction from Asystasia gangetica through response surface methodology and to optimize the extraction condition. The experiment was conducted based on the central composite design with two variabl...

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Main Authors: Norazwina, Zainol, Nor Hazwani, Aziz, Amir Syarifudin, Baharudin
Format: Article
Language:English
Published: Elsevier Ltd 2023
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/40789/1/Influence%20of%20agitation%20and%20solvent%20percentage%20on%20the%20extraction%20of%20phytochemical.pdf
http://umpir.ump.edu.my/id/eprint/40789/
https://doi.org/10.1016/j.focha.2023.100538
https://doi.org/10.1016/j.focha.2023.100538
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spelling my.ump.umpir.407892024-03-29T01:52:49Z http://umpir.ump.edu.my/id/eprint/40789/ Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica Norazwina, Zainol Nor Hazwani, Aziz Amir Syarifudin, Baharudin TP Chemical technology This study aims to investigate the influence of agitation and solvent percentage on the phytochemical extraction from Asystasia gangetica through response surface methodology and to optimize the extraction condition. The experiment was conducted based on the central composite design with two variables: solvent percentage and agitation speed. The total phenolic compound (Folin–Ciocalteu method), total flavonoid compound (Dowd method), and antioxidant activity (modified DPPH free radical scavenging assay), were analyzed through the analysis of variance. All models were significant (p-value <0.05) with strong R2 values (over 80 %), indicating satisfactory regression analysis. The optimum condition is achieved at 204 rpm agitation speed and 72 % solvent percentage with total phenolic, total flavonoid, and antioxidant activity at its maximum value of 0.2086 mg/ml, 0.2082 mg/ml, and 1.0494 nmol/ul, respectively. The influence of factors on each phytochemical varies, with both being significant for total flavonoid compound extraction and insignificant for antioxidant activity. Meanwhile, for the total phenolic compound, the solvent percentage is insignificant. Determining the significant factors during phytochemical extraction could be useful in tailoring the suitable range to maximize yield. The bioactive compounds and nutritional composition of A. gangetica could be used to develop functional foods and development of drugs to manage various disease. Elsevier Ltd 2023-12 Article PeerReviewed pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/40789/1/Influence%20of%20agitation%20and%20solvent%20percentage%20on%20the%20extraction%20of%20phytochemical.pdf Norazwina, Zainol and Nor Hazwani, Aziz and Amir Syarifudin, Baharudin (2023) Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica. Food Chemistry Advances, 3 (100538). pp. 1-8. ISSN 2772-753X. (Published) https://doi.org/10.1016/j.focha.2023.100538 https://doi.org/10.1016/j.focha.2023.100538
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Norazwina, Zainol
Nor Hazwani, Aziz
Amir Syarifudin, Baharudin
Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica
description This study aims to investigate the influence of agitation and solvent percentage on the phytochemical extraction from Asystasia gangetica through response surface methodology and to optimize the extraction condition. The experiment was conducted based on the central composite design with two variables: solvent percentage and agitation speed. The total phenolic compound (Folin–Ciocalteu method), total flavonoid compound (Dowd method), and antioxidant activity (modified DPPH free radical scavenging assay), were analyzed through the analysis of variance. All models were significant (p-value <0.05) with strong R2 values (over 80 %), indicating satisfactory regression analysis. The optimum condition is achieved at 204 rpm agitation speed and 72 % solvent percentage with total phenolic, total flavonoid, and antioxidant activity at its maximum value of 0.2086 mg/ml, 0.2082 mg/ml, and 1.0494 nmol/ul, respectively. The influence of factors on each phytochemical varies, with both being significant for total flavonoid compound extraction and insignificant for antioxidant activity. Meanwhile, for the total phenolic compound, the solvent percentage is insignificant. Determining the significant factors during phytochemical extraction could be useful in tailoring the suitable range to maximize yield. The bioactive compounds and nutritional composition of A. gangetica could be used to develop functional foods and development of drugs to manage various disease.
format Article
author Norazwina, Zainol
Nor Hazwani, Aziz
Amir Syarifudin, Baharudin
author_facet Norazwina, Zainol
Nor Hazwani, Aziz
Amir Syarifudin, Baharudin
author_sort Norazwina, Zainol
title Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica
title_short Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica
title_full Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica
title_fullStr Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica
title_full_unstemmed Influence of agitation and solvent percentage on the extraction of phytochemical compound from Asystasia gangetica
title_sort influence of agitation and solvent percentage on the extraction of phytochemical compound from asystasia gangetica
publisher Elsevier Ltd
publishDate 2023
url http://umpir.ump.edu.my/id/eprint/40789/1/Influence%20of%20agitation%20and%20solvent%20percentage%20on%20the%20extraction%20of%20phytochemical.pdf
http://umpir.ump.edu.my/id/eprint/40789/
https://doi.org/10.1016/j.focha.2023.100538
https://doi.org/10.1016/j.focha.2023.100538
_version_ 1822924213847064576
score 13.235796

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