Cover Image

A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation

A simple, sensitive and specific ultraviolet spectrophotometric method has been established for the determination of benidipine hydrochloride. The wavelength of maximum absorbance (λmax) for benidipine was found to be 237 nm. Linearity of this method was observed in a range of 2.0 – 16.0 μg/mL. The...

Full description

Saved in:
Bibliographic Details
Main Authors: AL-japairai, Khater Ahmed Saeed, Syed, Mahmood, Nadiya, Abdul Halim, Almurisi, Samah Hamed
Format: Article
Language:English
English
Published: Springer 2023
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/39285/2/A%20New%20and%20Rapid%20UV-Visible%20Spectrophotometric%20Method.pdf
http://umpir.ump.edu.my/id/eprint/39285/3/A%20new%20and%20rapid%20UV-Visible%20spectrophotometric%20method_abst.pdf
http://umpir.ump.edu.my/id/eprint/39285/
https://doi.org/10.1007/s11094-023-02822-3
https://doi.org/10.1007/s11094-023-02822-3
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.ump.umpir.39285
record_format eprints
spelling my.ump.umpir.392852023-11-14T02:48:25Z http://umpir.ump.edu.my/id/eprint/39285/ A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation AL-japairai, Khater Ahmed Saeed Syed, Mahmood Nadiya, Abdul Halim Almurisi, Samah Hamed TP Chemical technology A simple, sensitive and specific ultraviolet spectrophotometric method has been established for the determination of benidipine hydrochloride. The wavelength of maximum absorbance (λmax) for benidipine was found to be 237 nm. Linearity of this method was observed in a range of 2.0 – 16.0 μg/mL. The method showed high sensitivity with good reproducibility of results. The limit of detection and the limit of quantification were 0.34 and 1.02 μg/mL, respectively. The calibration curve was constructed by plotting a graph of the absorbance versus concentration. The coefficient of correlation was higher than 0.99. The regression equation of this curve is y = 0.0544x – 0.0526. The percentage of drug recovery was found in the acceptable range (99.72 – 101.66%), and the coefficient of variation for the precision of this method was found to be less than 2.0. The proposed method can be suitable for the analysis of benidipine in tablet formulations for quality control purposes. Springer 2023-02 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/39285/2/A%20New%20and%20Rapid%20UV-Visible%20Spectrophotometric%20Method.pdf pdf en http://umpir.ump.edu.my/id/eprint/39285/3/A%20new%20and%20rapid%20UV-Visible%20spectrophotometric%20method_abst.pdf AL-japairai, Khater Ahmed Saeed and Syed, Mahmood and Nadiya, Abdul Halim and Almurisi, Samah Hamed (2023) A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation. Pharmaceutical Chemistry Journal, 56 (11). 1506 -1511. ISSN 0091-150X. (Published) https://doi.org/10.1007/s11094-023-02822-3 https://doi.org/10.1007/s11094-023-02822-3
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
English
topic TP Chemical technology
spellingShingle TP Chemical technology
AL-japairai, Khater Ahmed Saeed
Syed, Mahmood
Nadiya, Abdul Halim
Almurisi, Samah Hamed
A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation
description A simple, sensitive and specific ultraviolet spectrophotometric method has been established for the determination of benidipine hydrochloride. The wavelength of maximum absorbance (λmax) for benidipine was found to be 237 nm. Linearity of this method was observed in a range of 2.0 – 16.0 μg/mL. The method showed high sensitivity with good reproducibility of results. The limit of detection and the limit of quantification were 0.34 and 1.02 μg/mL, respectively. The calibration curve was constructed by plotting a graph of the absorbance versus concentration. The coefficient of correlation was higher than 0.99. The regression equation of this curve is y = 0.0544x – 0.0526. The percentage of drug recovery was found in the acceptable range (99.72 – 101.66%), and the coefficient of variation for the precision of this method was found to be less than 2.0. The proposed method can be suitable for the analysis of benidipine in tablet formulations for quality control purposes.
format Article
author AL-japairai, Khater Ahmed Saeed
Syed, Mahmood
Nadiya, Abdul Halim
Almurisi, Samah Hamed
author_facet AL-japairai, Khater Ahmed Saeed
Syed, Mahmood
Nadiya, Abdul Halim
Almurisi, Samah Hamed
author_sort AL-japairai, Khater Ahmed Saeed
title A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation
title_short A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation
title_full A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation
title_fullStr A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation
title_full_unstemmed A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation
title_sort new and rapid uv-visible spectrophotometric method for benidipine hydrochloride determination: development and validation
publisher Springer
publishDate 2023
url http://umpir.ump.edu.my/id/eprint/39285/2/A%20New%20and%20Rapid%20UV-Visible%20Spectrophotometric%20Method.pdf
http://umpir.ump.edu.my/id/eprint/39285/3/A%20new%20and%20rapid%20UV-Visible%20spectrophotometric%20method_abst.pdf
http://umpir.ump.edu.my/id/eprint/39285/
https://doi.org/10.1007/s11094-023-02822-3
https://doi.org/10.1007/s11094-023-02822-3
_version_ 1822923853198786560
score 13.235796

Similar Items