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Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling

Age is a major risk for heart failure, which is associated with the reduction in ventricular compliance, increase in arterial stiffening, and increase in systemic vascular resistance. In this study, a lumped-parameter model is used to investigate the effect of aging on the possibility of heart failu...

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Main Authors: Siti Munirah, Muhammad Ali, El-Bouri, Wahbi K., Mohd Jamil, Mohamed Mokhtarudin
Format: Conference or Workshop Item
Language:English
English
Published: Institute of Electrical and Electronics Engineers Inc. 2022
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TK Electrical engineering. Electronics Nuclear engineering
TS Manufactures
Online Access:http://umpir.ump.edu.my/id/eprint/39079/1/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped.pdf
http://umpir.ump.edu.my/id/eprint/39079/2/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped-parameter%20modelling_ABS.pdf
http://umpir.ump.edu.my/id/eprint/39079/
https://doi.org/10.1109/IECBES54088.2022.10079315
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spelling my.ump.umpir.390792023-11-14T03:39:21Z http://umpir.ump.edu.my/id/eprint/39079/ Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling Siti Munirah, Muhammad Ali El-Bouri, Wahbi K. Mohd Jamil, Mohamed Mokhtarudin T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering TS Manufactures Age is a major risk for heart failure, which is associated with the reduction in ventricular compliance, increase in arterial stiffening, and increase in systemic vascular resistance. In this study, a lumped-parameter model is used to investigate the effect of aging on the possibility of heart failure occurrence. Model parameters including the systemic and pulmonary arterial compliance and resistance, and the left ventricular elastance are calculated for different ages using a ratio-based method. These parameters are then used in the lumped-parameter model. Our findings show that as age increases, there is a leftward and a rightward shift in the left ventricle and right ventricle pressure-volume loops, respectively. For the left ventricle, there is a decrease in stroke volume and an increase in ventricular pressure as the age increases. This correlates with the occurrence of arterial hypertension in the older population. Meanwhile, the right ventricular pressure is maintained as the population gets older, despite the increase in the stroke volume. This is possibly due to the shift in intraventricular septum that causes an enlargement of the right ventricle as the age increases. This study provides understanding on the effect of age on the occurrence of heart failure.This study demonstrates the relationship of aging with cardiac hemodynamics, which provides the potential risk of heart failure occurrence. Although there are many risk factors that can cause heart failure, aging has been strongly associated with its occurrence. Understanding how age affects heart failure can help to differentiate them from other effects such as dietary, gender, and early cardiovascular diseases including arrhythmia and myocardial infarction. Institute of Electrical and Electronics Engineers Inc. 2022 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/39079/1/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped.pdf pdf en http://umpir.ump.edu.my/id/eprint/39079/2/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped-parameter%20modelling_ABS.pdf Siti Munirah, Muhammad Ali and El-Bouri, Wahbi K. and Mohd Jamil, Mohamed Mokhtarudin (2022) Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling. In: 7th IEEE-EMBS Conference on Biomedical Engineering and Sciences, IECBES 2022 - Proceedings, 7-9 December 2022 , Virtual, Online. pp. 160-164. (187642). ISBN 978-166549469-4 https://doi.org/10.1109/IECBES54088.2022.10079315
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TK Electrical engineering. Electronics Nuclear engineering
TS Manufactures
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TK Electrical engineering. Electronics Nuclear engineering
TS Manufactures
Siti Munirah, Muhammad Ali
El-Bouri, Wahbi K.
Mohd Jamil, Mohamed Mokhtarudin
Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling
description Age is a major risk for heart failure, which is associated with the reduction in ventricular compliance, increase in arterial stiffening, and increase in systemic vascular resistance. In this study, a lumped-parameter model is used to investigate the effect of aging on the possibility of heart failure occurrence. Model parameters including the systemic and pulmonary arterial compliance and resistance, and the left ventricular elastance are calculated for different ages using a ratio-based method. These parameters are then used in the lumped-parameter model. Our findings show that as age increases, there is a leftward and a rightward shift in the left ventricle and right ventricle pressure-volume loops, respectively. For the left ventricle, there is a decrease in stroke volume and an increase in ventricular pressure as the age increases. This correlates with the occurrence of arterial hypertension in the older population. Meanwhile, the right ventricular pressure is maintained as the population gets older, despite the increase in the stroke volume. This is possibly due to the shift in intraventricular septum that causes an enlargement of the right ventricle as the age increases. This study provides understanding on the effect of age on the occurrence of heart failure.This study demonstrates the relationship of aging with cardiac hemodynamics, which provides the potential risk of heart failure occurrence. Although there are many risk factors that can cause heart failure, aging has been strongly associated with its occurrence. Understanding how age affects heart failure can help to differentiate them from other effects such as dietary, gender, and early cardiovascular diseases including arrhythmia and myocardial infarction.
format Conference or Workshop Item
author Siti Munirah, Muhammad Ali
El-Bouri, Wahbi K.
Mohd Jamil, Mohamed Mokhtarudin
author_facet Siti Munirah, Muhammad Ali
El-Bouri, Wahbi K.
Mohd Jamil, Mohamed Mokhtarudin
author_sort Siti Munirah, Muhammad Ali
title Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling
title_short Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling
title_full Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling
title_fullStr Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling
title_full_unstemmed Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling
title_sort age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling
publisher Institute of Electrical and Electronics Engineers Inc.
publishDate 2022
url http://umpir.ump.edu.my/id/eprint/39079/1/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped.pdf
http://umpir.ump.edu.my/id/eprint/39079/2/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped-parameter%20modelling_ABS.pdf
http://umpir.ump.edu.my/id/eprint/39079/
https://doi.org/10.1109/IECBES54088.2022.10079315
_version_ 1822923821569540096
score 13.235362

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