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Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review

Benefits achieved by the biodegradable magnesium (Mg) and zinc (Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resis...

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Main Authors: Shahed, Chowdhury Ahmed, Faiz, Ahmad, Günister, Ebru, Farhana, Mohd Foudzi, Ali, Saad, Malik, Khurshid, Wan Sharuzi, Wan Harun
Format: Article
Language:English
Published: KeAi Communications Co. 2023
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
Online Access:http://umpir.ump.edu.my/id/eprint/38877/1/Antibacterial%20mechanism%20with%20consequent%20cytotoxicity%20of%20different%20reinforcements.pdf
http://umpir.ump.edu.my/id/eprint/38877/
https://doi.org/10.1016/j.jma.2023.08.018
https://doi.org/10.1016/j.jma.2023.08.018
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spelling my.ump.umpir.388772023-11-14T02:32:49Z http://umpir.ump.edu.my/id/eprint/38877/ Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review Shahed, Chowdhury Ahmed Faiz, Ahmad Günister, Ebru Farhana, Mohd Foudzi Ali, Saad Malik, Khurshid Wan Sharuzi, Wan Harun T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics Benefits achieved by the biodegradable magnesium (Mg) and zinc (Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resistant bacteria, bringing osteomyelitis, necrosis, and even death. This study evaluates the antibacterial performance of biodegradable Mg and Zn alloys of different reinforcements, including silver (Ag), copper (Cu), lithium (Li), and gallium (Ga). Copper ions (Cu2+) can eradicate biofilms and antibiotic-resistant bacteria by extracting electrons from the cellular structure. Silver ion (Ag+) kills bacteria by creating bonds with the thiol group. Gallium ion (Ga3+) inhibits ferric ion (Fe3+) absorption, leading to nutrient deficiency and bacterial death. Nanoparticles and reactive oxygen species (ROS) can penetrate bacteria cell walls directly, develop bonds with receptors, and damage nucleotides. Antibacterial action depends on the alkali nature of metal ions and their degradation rate, which often causes cytotoxicity in living cells. Therefore, this review emphasizes the insight into degradation rate, antibacterial mechanism, and their consequent cytotoxicity and observes the correlation between antibacterial performance and oxidation number of metal ions. KeAi Communications Co. 2023 Article PeerReviewed pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/38877/1/Antibacterial%20mechanism%20with%20consequent%20cytotoxicity%20of%20different%20reinforcements.pdf Shahed, Chowdhury Ahmed and Faiz, Ahmad and Günister, Ebru and Farhana, Mohd Foudzi and Ali, Saad and Malik, Khurshid and Wan Sharuzi, Wan Harun (2023) Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review. Journal of Magnesium and Alloys. pp. 1-21. ISSN 2213-9567. (Published) https://doi.org/10.1016/j.jma.2023.08.018 https://doi.org/10.1016/j.jma.2023.08.018
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
Shahed, Chowdhury Ahmed
Faiz, Ahmad
Günister, Ebru
Farhana, Mohd Foudzi
Ali, Saad
Malik, Khurshid
Wan Sharuzi, Wan Harun
Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review
description Benefits achieved by the biodegradable magnesium (Mg) and zinc (Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resistant bacteria, bringing osteomyelitis, necrosis, and even death. This study evaluates the antibacterial performance of biodegradable Mg and Zn alloys of different reinforcements, including silver (Ag), copper (Cu), lithium (Li), and gallium (Ga). Copper ions (Cu2+) can eradicate biofilms and antibiotic-resistant bacteria by extracting electrons from the cellular structure. Silver ion (Ag+) kills bacteria by creating bonds with the thiol group. Gallium ion (Ga3+) inhibits ferric ion (Fe3+) absorption, leading to nutrient deficiency and bacterial death. Nanoparticles and reactive oxygen species (ROS) can penetrate bacteria cell walls directly, develop bonds with receptors, and damage nucleotides. Antibacterial action depends on the alkali nature of metal ions and their degradation rate, which often causes cytotoxicity in living cells. Therefore, this review emphasizes the insight into degradation rate, antibacterial mechanism, and their consequent cytotoxicity and observes the correlation between antibacterial performance and oxidation number of metal ions.
format Article
author Shahed, Chowdhury Ahmed
Faiz, Ahmad
Günister, Ebru
Farhana, Mohd Foudzi
Ali, Saad
Malik, Khurshid
Wan Sharuzi, Wan Harun
author_facet Shahed, Chowdhury Ahmed
Faiz, Ahmad
Günister, Ebru
Farhana, Mohd Foudzi
Ali, Saad
Malik, Khurshid
Wan Sharuzi, Wan Harun
author_sort Shahed, Chowdhury Ahmed
title Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review
title_short Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review
title_full Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review
title_fullStr Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review
title_full_unstemmed Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : A review
title_sort antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys : a review
publisher KeAi Communications Co.
publishDate 2023
url http://umpir.ump.edu.my/id/eprint/38877/1/Antibacterial%20mechanism%20with%20consequent%20cytotoxicity%20of%20different%20reinforcements.pdf
http://umpir.ump.edu.my/id/eprint/38877/
https://doi.org/10.1016/j.jma.2023.08.018
https://doi.org/10.1016/j.jma.2023.08.018
_version_ 1822923772767764480
score 13.244413

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