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3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities

Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis...

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Main Authors: Aldhaher, Abdullah, Shahabipour, Fahimeh, Shaito, Abdullah, Al-Assaf, Saphwan, Elnour, Ahmed A.M., Sallam, El Bashier, Teimourtash, Shahin, A. Elfadil, Abdelgadir
Format: Article
Language:English
Published: Elsevier Ltd 2023
Subjects:
QD Chemistry
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/38862/1/Dr.%20Ahmed_%20Helyion_Research%20Artical.pdf
http://umpir.ump.edu.my/id/eprint/38862/
https://doi.org/10.1016/j.heliyon.2023.e17050
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spelling my.ump.umpir.388622023-10-12T06:16:28Z http://umpir.ump.edu.my/id/eprint/38862/ 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin A. Elfadil, Abdelgadir QD Chemistry TP Chemical technology Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials. Elsevier Ltd 2023 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/38862/1/Dr.%20Ahmed_%20Helyion_Research%20Artical.pdf Aldhaher, Abdullah and Shahabipour, Fahimeh and Shaito, Abdullah and Al-Assaf, Saphwan and Elnour, Ahmed A.M. and Sallam, El Bashier and Teimourtash, Shahin and A. Elfadil, Abdelgadir (2023) 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities. Heliyon, 9 (7). ISSN 2405-8440. (Published) https://doi.org/10.1016/j.heliyon.2023.e17050 10.1016/j.heliyon.2023.e17050
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QD Chemistry
TP Chemical technology
spellingShingle QD Chemistry
TP Chemical technology
Aldhaher, Abdullah
Shahabipour, Fahimeh
Shaito, Abdullah
Al-Assaf, Saphwan
Elnour, Ahmed A.M.
Sallam, El Bashier
Teimourtash, Shahin
A. Elfadil, Abdelgadir
3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
description Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials.
format Article
author Aldhaher, Abdullah
Shahabipour, Fahimeh
Shaito, Abdullah
Al-Assaf, Saphwan
Elnour, Ahmed A.M.
Sallam, El Bashier
Teimourtash, Shahin
A. Elfadil, Abdelgadir
author_facet Aldhaher, Abdullah
Shahabipour, Fahimeh
Shaito, Abdullah
Al-Assaf, Saphwan
Elnour, Ahmed A.M.
Sallam, El Bashier
Teimourtash, Shahin
A. Elfadil, Abdelgadir
author_sort Aldhaher, Abdullah
title 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
title_short 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
title_full 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
title_fullStr 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
title_full_unstemmed 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
title_sort 3d hydrogel/ bioactive glass scaffolds in bone tissue engineering: status and future opportunities
publisher Elsevier Ltd
publishDate 2023
url http://umpir.ump.edu.my/id/eprint/38862/1/Dr.%20Ahmed_%20Helyion_Research%20Artical.pdf
http://umpir.ump.edu.my/id/eprint/38862/
https://doi.org/10.1016/j.heliyon.2023.e17050
_version_ 1822923768717115392
score 13.235796

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