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Aptamer-based rapid diagnosis for point-of-care application

Aptasensors have attracted considerable interest and widespread application in point-of-care testing worldwide. One of the biggest challenges of a point-of-care (POC) is the reduction of treatment time compared to central facilities that diagnose and monitor the applications. Over the past decades,...

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Main Authors:	Futane, Abhishek, Narayanamurthy, Vigneswaran, Jadhav, Pramod, Srinivasan, Arthi
Format:	Article
Language:	English English
Published:	Springer Science and Business Media Deutschland GmbH 2023
Subjects:	QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/38694/1/Aptamer-based%20rapid%20diagnosis%20for%20point-of-care%20application.pdf http://umpir.ump.edu.my/id/eprint/38694/2/Aptamer-based%20rapid%20diagnosis%20for%20point-of-care%20application_ABS.pdf http://umpir.ump.edu.my/id/eprint/38694/ https://doi.org/10.1007/s10404-022-02622-3 https://doi.org/10.1007/s10404-022-02622-3
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spelling	my.ump.umpir.386942023-10-31T07:34:12Z http://umpir.ump.edu.my/id/eprint/38694/ Aptamer-based rapid diagnosis for point-of-care application Futane, Abhishek Narayanamurthy, Vigneswaran Jadhav, Pramod Srinivasan, Arthi QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Aptasensors have attracted considerable interest and widespread application in point-of-care testing worldwide. One of the biggest challenges of a point-of-care (POC) is the reduction of treatment time compared to central facilities that diagnose and monitor the applications. Over the past decades, biosensors have been introduced that offer more reliable, cost-effective, and accurate detection methods. Aptamer-based biosensors have unprecedented advantages over biosensors that use natural receptors such as antibodies and enzymes. In the current epidemic, point-of-care testing (POCT) is advantageous because it is easy to use, more accessible, faster to detect, and has high accuracy and sensitivity, reducing the burden of testing on healthcare systems. POCT is beneficial for daily epidemic control as well as early detection and treatment. This review provides detailed information on the various design strategies and virus detection methods using aptamer-based sensors. In addition, we discussed the importance of different aptamers and their detection principles. Aptasensors with higher sensitivity, specificity, and flexibility are critically discussed to establish simple, cost-effective, and rapid detection methods. POC-based aptasensors’ diagnostic applications are classified and summarised based on infectious and infectious diseases. Finally, the design factors to be considered are outlined to meet the future of rapid POC-based sensors. Springer Science and Business Media Deutschland GmbH 2023-02 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/38694/1/Aptamer-based%20rapid%20diagnosis%20for%20point-of-care%20application.pdf pdf en http://umpir.ump.edu.my/id/eprint/38694/2/Aptamer-based%20rapid%20diagnosis%20for%20point-of-care%20application_ABS.pdf Futane, Abhishek and Narayanamurthy, Vigneswaran and Jadhav, Pramod and Srinivasan, Arthi (2023) Aptamer-based rapid diagnosis for point-of-care application. Microfluidics and Nanofluidics, 27 (15). pp. 1-33. ISSN 1613-4982. (Published) https://doi.org/10.1007/s10404-022-02622-3 https://doi.org/10.1007/s10404-022-02622-3
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
building	UMPSA Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Pahang Al-Sultan Abdullah
content_source	UMPSA Institutional Repository
url_provider	http://umpir.ump.edu.my/
language	English English
topic	QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology
spellingShingle	QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Futane, Abhishek Narayanamurthy, Vigneswaran Jadhav, Pramod Srinivasan, Arthi Aptamer-based rapid diagnosis for point-of-care application
description	Aptasensors have attracted considerable interest and widespread application in point-of-care testing worldwide. One of the biggest challenges of a point-of-care (POC) is the reduction of treatment time compared to central facilities that diagnose and monitor the applications. Over the past decades, biosensors have been introduced that offer more reliable, cost-effective, and accurate detection methods. Aptamer-based biosensors have unprecedented advantages over biosensors that use natural receptors such as antibodies and enzymes. In the current epidemic, point-of-care testing (POCT) is advantageous because it is easy to use, more accessible, faster to detect, and has high accuracy and sensitivity, reducing the burden of testing on healthcare systems. POCT is beneficial for daily epidemic control as well as early detection and treatment. This review provides detailed information on the various design strategies and virus detection methods using aptamer-based sensors. In addition, we discussed the importance of different aptamers and their detection principles. Aptasensors with higher sensitivity, specificity, and flexibility are critically discussed to establish simple, cost-effective, and rapid detection methods. POC-based aptasensors’ diagnostic applications are classified and summarised based on infectious and infectious diseases. Finally, the design factors to be considered are outlined to meet the future of rapid POC-based sensors.
format	Article
author	Futane, Abhishek Narayanamurthy, Vigneswaran Jadhav, Pramod Srinivasan, Arthi
author_facet	Futane, Abhishek Narayanamurthy, Vigneswaran Jadhav, Pramod Srinivasan, Arthi
author_sort	Futane, Abhishek
title	Aptamer-based rapid diagnosis for point-of-care application
title_short	Aptamer-based rapid diagnosis for point-of-care application
title_full	Aptamer-based rapid diagnosis for point-of-care application
title_fullStr	Aptamer-based rapid diagnosis for point-of-care application
title_full_unstemmed	Aptamer-based rapid diagnosis for point-of-care application
title_sort	aptamer-based rapid diagnosis for point-of-care application
publisher	Springer Science and Business Media Deutschland GmbH
publishDate	2023
url	http://umpir.ump.edu.my/id/eprint/38694/1/Aptamer-based%20rapid%20diagnosis%20for%20point-of-care%20application.pdf http://umpir.ump.edu.my/id/eprint/38694/2/Aptamer-based%20rapid%20diagnosis%20for%20point-of-care%20application_ABS.pdf http://umpir.ump.edu.my/id/eprint/38694/ https://doi.org/10.1007/s10404-022-02622-3 https://doi.org/10.1007/s10404-022-02622-3
_version_	1822923719927922688
score	13.232414

Aptamer-based rapid diagnosis for point-of-care application

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