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The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial

Probiotics are widely used as an adjuvant therapy in various diseases. Nonetheless, it is uncertain how they affect the gut microbiota composition and metabolic and inflammatory outcomes in women who have recently experienced gestational diabetes mellitus (post-GDM). A randomized, double-blind, plac...

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Main Authors: Zubaidah, Hasain, Raja Affendi, Raja Ali, Hajar Fauzan, Ahmad, Ummul Fahri, Abdul Rauf, Oon, Seok Fang, Norfilza Mohd, Mokhtar
Format: Article
Language:English
Published: MDPI 2022
Subjects:
HD28 Management. Industrial Management
Q Science (General)
T Technology (General)
Online Access:http://umpir.ump.edu.my/id/eprint/37443/1/The%20roles%20of%20probiotics%20in%20the%20gut%20microbiota%20composition%20and%20metabolic%20outcomes%20in%20asymptomatic%20post-gestational%20diabetes%20women.pdf
http://umpir.ump.edu.my/id/eprint/37443/
https://doi.org/10.3390/nu14183878
https://doi.org/10.3390/nu14183878
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spelling my.ump.umpir.374432023-07-20T03:50:53Z http://umpir.ump.edu.my/id/eprint/37443/ The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial Zubaidah, Hasain Raja Affendi, Raja Ali Hajar Fauzan, Ahmad Ummul Fahri, Abdul Rauf Oon, Seok Fang Norfilza Mohd, Mokhtar HD28 Management. Industrial Management Q Science (General) T Technology (General) Probiotics are widely used as an adjuvant therapy in various diseases. Nonetheless, it is uncertain how they affect the gut microbiota composition and metabolic and inflammatory outcomes in women who have recently experienced gestational diabetes mellitus (post-GDM). A randomized, double-blind, placebo-controlled clinical trial involving 132 asymptomatic post-GDM women was conducted to close this gap (Clinical Trial Registration: NCT05273073). The intervention (probiotics) group received a cocktail of six probiotic strains from Bifidobacterium and Lactobacillus for 12 weeks, while the placebo group received an identical sachet devoid of living microorganisms. Anthropometric measurements, biochemical analyses, and 16S rRNA gene sequencing results were evaluated pre- and post-intervention. After the 12-week intervention, the probiotics group’s fasting blood glucose level significantly decreased (mean difference −0.20 mmol/L; p = 0.0021). The HbA1c, total cholesterol, triglycerides, and high-sensitivity C-reactive protein levels were significantly different between the two groups (p < 0.05). Sequencing data also demonstrated a large rise in the Bifidobacterium adolescentis following probiotic supplementation. Our findings suggest that multi-strain probiotics are beneficial for improved metabolic and inflammatory outcomes in post-GDM women by modulating gut dysbiosis. This study emphasizes the necessity for a comprehensive strategy for postpartum treatment that includes probiotics to protect post-GDM women from developing glucose intolerance. MDPI 2022-09 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/37443/1/The%20roles%20of%20probiotics%20in%20the%20gut%20microbiota%20composition%20and%20metabolic%20outcomes%20in%20asymptomatic%20post-gestational%20diabetes%20women.pdf Zubaidah, Hasain and Raja Affendi, Raja Ali and Hajar Fauzan, Ahmad and Ummul Fahri, Abdul Rauf and Oon, Seok Fang and Norfilza Mohd, Mokhtar (2022) The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial. Nutrients, 14 (18). 3878--. ISSN 2072-6643. (Published) https://doi.org/10.3390/nu14183878 https://doi.org/10.3390/nu14183878
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic HD28 Management. Industrial Management
Q Science (General)
T Technology (General)
spellingShingle HD28 Management. Industrial Management
Q Science (General)
T Technology (General)
Zubaidah, Hasain
Raja Affendi, Raja Ali
Hajar Fauzan, Ahmad
Ummul Fahri, Abdul Rauf
Oon, Seok Fang
Norfilza Mohd, Mokhtar
The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial
description Probiotics are widely used as an adjuvant therapy in various diseases. Nonetheless, it is uncertain how they affect the gut microbiota composition and metabolic and inflammatory outcomes in women who have recently experienced gestational diabetes mellitus (post-GDM). A randomized, double-blind, placebo-controlled clinical trial involving 132 asymptomatic post-GDM women was conducted to close this gap (Clinical Trial Registration: NCT05273073). The intervention (probiotics) group received a cocktail of six probiotic strains from Bifidobacterium and Lactobacillus for 12 weeks, while the placebo group received an identical sachet devoid of living microorganisms. Anthropometric measurements, biochemical analyses, and 16S rRNA gene sequencing results were evaluated pre- and post-intervention. After the 12-week intervention, the probiotics group’s fasting blood glucose level significantly decreased (mean difference −0.20 mmol/L; p = 0.0021). The HbA1c, total cholesterol, triglycerides, and high-sensitivity C-reactive protein levels were significantly different between the two groups (p < 0.05). Sequencing data also demonstrated a large rise in the Bifidobacterium adolescentis following probiotic supplementation. Our findings suggest that multi-strain probiotics are beneficial for improved metabolic and inflammatory outcomes in post-GDM women by modulating gut dysbiosis. This study emphasizes the necessity for a comprehensive strategy for postpartum treatment that includes probiotics to protect post-GDM women from developing glucose intolerance.
format Article
author Zubaidah, Hasain
Raja Affendi, Raja Ali
Hajar Fauzan, Ahmad
Ummul Fahri, Abdul Rauf
Oon, Seok Fang
Norfilza Mohd, Mokhtar
author_facet Zubaidah, Hasain
Raja Affendi, Raja Ali
Hajar Fauzan, Ahmad
Ummul Fahri, Abdul Rauf
Oon, Seok Fang
Norfilza Mohd, Mokhtar
author_sort Zubaidah, Hasain
title The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial
title_short The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial
title_full The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial
title_fullStr The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial
title_full_unstemmed The roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : A randomized controlled trial
title_sort roles of probiotics in the gut microbiota composition and metabolic outcomes in asymptomatic post-gestational diabetes women : a randomized controlled trial
publisher MDPI
publishDate 2022
url http://umpir.ump.edu.my/id/eprint/37443/1/The%20roles%20of%20probiotics%20in%20the%20gut%20microbiota%20composition%20and%20metabolic%20outcomes%20in%20asymptomatic%20post-gestational%20diabetes%20women.pdf
http://umpir.ump.edu.my/id/eprint/37443/
https://doi.org/10.3390/nu14183878
https://doi.org/10.3390/nu14183878
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score 13.211869

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