Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation
The current study offers a controlled release of niacinamide from fibrous silica (KCC-1) loaded in face serum formulation. Furthermore, three drug loading methods namely physical mixing, (Phy)/Nia-KCC-1, melting (Mel)/Nia-KCC-1 and solvent evaporation, (Sol)/Nia-KCC-1 were implemented and the percen...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Universiti Malaysia Pahang
2022
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/36797/1/Controlled%20release%20of%20niacinamide%20from%20fibrous%20silica%20nanocarrier%20in%20face%20serum%20formulation.pdf http://umpir.ump.edu.my/id/eprint/36797/ https://ncon-pgr.ump.edu.my/index.php/en/?option=com_fileman&view=file&routed=1&name=E-BOOK%20NCON%202022%20.pdf&folder=E-BOOK%20NCON%202022&container=fileman-files |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The current study offers a controlled release of niacinamide from fibrous silica (KCC-1) loaded in face serum formulation. Furthermore, three drug loading methods namely physical mixing, (Phy)/Nia-KCC-1, melting (Mel)/Nia-KCC-1 and solvent evaporation, (Sol)/Nia-KCC-1 were implemented and the percentage loading efficiency were compared. (Mel)/Nia-KCC-1 demonstrated highest percentage drug loading at 33%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 25% and 17%, respectively. Likewise, the in vitro release study also revealed similar pattern with (Mel)/Nia-KCC-1 recorded highest percentage release at 29%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 24% and 21%, respectively. As (Mel)/Nia-KCC-1 sample unveiled decent result in transporting the sample drug, the respective sample was then further loaded into the face serum formulation and the pH stability was observed for 7 days. The pH readings were at constant pH 4.3 throughout 7 days, in acceptance range according to the derma-cosmetic product that stated the effective pH is supposed to lies between pH 4 to pH 6. Therefore, it can be stated that the (Mel)/Nia-KCC-1 serum fulfilled the acceptance criteria of Ph requirement for the derma-cosmetics products. |
|---|