Staff View: Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples

Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples

Official figures for drug abuse and seizure rates in Malaysia are currently obtained from drug sweep operations carried out by The Royal Malaysia Police (PDRM) in collaboration with The National Antidrug Agency (AADK). This method can provide a useful general picture of drug abuse in our society, bu...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohammad Azimuddin, Izani, Nurul `Azyyati, Sabri, Nurul Nadiah, Hamidon, Kooi Yeong, Khaw, Iekhsan, Othman, Mueller, Jochen, Joo Hui, Tay
Format:	Conference or Workshop Item
Language:	English
Published:	Universiti Teknologi MARA 2022
Subjects:	RA0421 Public health. Hygiene. Preventive Medicine TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/35778/1/Izani%20et%20al.pdf http://umpir.ump.edu.my/id/eprint/35778/
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.ump.umpir.35778
record_format	eprints
spelling	my.ump.umpir.357782022-11-29T06:14:12Z http://umpir.ump.edu.my/id/eprint/35778/ Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples Mohammad Azimuddin, Izani Nurul `Azyyati, Sabri Nurul Nadiah, Hamidon Kooi Yeong, Khaw Iekhsan, Othman Mueller, Jochen Joo Hui, Tay RA0421 Public health. Hygiene. Preventive Medicine TP Chemical technology Official figures for drug abuse and seizure rates in Malaysia are currently obtained from drug sweep operations carried out by The Royal Malaysia Police (PDRM) in collaboration with The National Antidrug Agency (AADK). This method can provide a useful general picture of drug abuse in our society, but consumption rates and drug use prevalence may be underestimated because the data is obtained directly from consumers. Wastewater-based epidemiology (WBE) has been widely used to objectively monitor population-level drug use, particularly in the Western countries [1-4]. By collecting raw sewage samples from municipal wastewater treatment plants (WWTPs) and quantifying the concentrations of drug residues or its metabolites in the samples, the population-normalized total consumption for a given drug within the population of a sewage treatment service area could be estimated. In this study, an analytical method based on solid phase extraction (SPE) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was validated for the determination of amphetamine (AM), methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), and morphine (MOR) in wastewater. The method was tested on sewage samples collected from WWTPs in the Kuantan area to see if it was sensitive enough to detect these compounds. In the future, this method will be applied to assess the consumption of these drugs using the WBE approach. Universiti Teknologi MARA 2022 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/35778/1/Izani%20et%20al.pdf Mohammad Azimuddin, Izani and Nurul `Azyyati, Sabri and Nurul Nadiah, Hamidon and Kooi Yeong, Khaw and Iekhsan, Othman and Mueller, Jochen and Joo Hui, Tay (2022) Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples. In: 2 nd Applied Science Research International Conference 2022 (2 nd ASRIC 2022), 21 September 2022 , Virtual Conference. pp. 1-3.. ISBN 978-629-97630 (online)
institution	Universiti Malaysia Pahang
building	UMP Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Pahang
content_source	UMP Institutional Repository
url_provider	http://umpir.ump.edu.my/
language	English
topic	RA0421 Public health. Hygiene. Preventive Medicine TP Chemical technology
spellingShingle	RA0421 Public health. Hygiene. Preventive Medicine TP Chemical technology Mohammad Azimuddin, Izani Nurul `Azyyati, Sabri Nurul Nadiah, Hamidon Kooi Yeong, Khaw Iekhsan, Othman Mueller, Jochen Joo Hui, Tay Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples
description	Official figures for drug abuse and seizure rates in Malaysia are currently obtained from drug sweep operations carried out by The Royal Malaysia Police (PDRM) in collaboration with The National Antidrug Agency (AADK). This method can provide a useful general picture of drug abuse in our society, but consumption rates and drug use prevalence may be underestimated because the data is obtained directly from consumers. Wastewater-based epidemiology (WBE) has been widely used to objectively monitor population-level drug use, particularly in the Western countries [1-4]. By collecting raw sewage samples from municipal wastewater treatment plants (WWTPs) and quantifying the concentrations of drug residues or its metabolites in the samples, the population-normalized total consumption for a given drug within the population of a sewage treatment service area could be estimated. In this study, an analytical method based on solid phase extraction (SPE) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was validated for the determination of amphetamine (AM), methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), and morphine (MOR) in wastewater. The method was tested on sewage samples collected from WWTPs in the Kuantan area to see if it was sensitive enough to detect these compounds. In the future, this method will be applied to assess the consumption of these drugs using the WBE approach.
format	Conference or Workshop Item
author	Mohammad Azimuddin, Izani Nurul `Azyyati, Sabri Nurul Nadiah, Hamidon Kooi Yeong, Khaw Iekhsan, Othman Mueller, Jochen Joo Hui, Tay
author_facet	Mohammad Azimuddin, Izani Nurul `Azyyati, Sabri Nurul Nadiah, Hamidon Kooi Yeong, Khaw Iekhsan, Othman Mueller, Jochen Joo Hui, Tay
author_sort	Mohammad Azimuddin, Izani
title	Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples
title_short	Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples
title_full	Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples
title_fullStr	Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples
title_full_unstemmed	Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples
title_sort	validation of analytical method for testing the levels of illicit drugs in municipal wastewater influent samples
publisher	Universiti Teknologi MARA
publishDate	2022
url	http://umpir.ump.edu.my/id/eprint/35778/1/Izani%20et%20al.pdf http://umpir.ump.edu.my/id/eprint/35778/
_version_	1751536401670733824
score	13.211869

Validation of analytical method for testing the levels of illicit drugs in Municipal Wastewater influent samples

Similar Items