Staff View: Mapping the human genetic architecture of COVID-19

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-speci...

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Main Author:	Hajar Fauzan, Ahmad
Format:	Article
Language:	English
Published:	Springer Nature 2021
Subjects:	HV Social pathology. Social and public welfare RA Public aspects of medicine RA0421 Public health. Hygiene. Preventive Medicine
Online Access:	http://umpir.ump.edu.my/id/eprint/35374/3/Mapping%20the%20human%20genetic%20architecture%20of%20COVID.docx http://umpir.ump.edu.my/id/eprint/35374/ https://www.nature.com/articles/s41586-021-03767-x#Sec5 https://doi.org/10.1038/s41586-021-03767-x
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spelling	my.ump.umpir.353742022-10-07T05:11:31Z http://umpir.ump.edu.my/id/eprint/35374/ Mapping the human genetic architecture of COVID-19 Hajar Fauzan, Ahmad HV Social pathology. Social and public welfare RA Public aspects of medicine RA0421 Public health. Hygiene. Preventive Medicine The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease. Springer Nature 2021 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/35374/3/Mapping%20the%20human%20genetic%20architecture%20of%20COVID.docx Hajar Fauzan, Ahmad (2021) Mapping the human genetic architecture of COVID-19. Nature, 600. pp. 472-477. ISSN ISSN 1476-4687 (online) ISSN 0028-0836 (print) https://www.nature.com/articles/s41586-021-03767-x#Sec5 https://doi.org/10.1038/s41586-021-03767-x
institution	Universiti Malaysia Pahang
building	UMP Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Pahang
content_source	UMP Institutional Repository
url_provider	http://umpir.ump.edu.my/
language	English
topic	HV Social pathology. Social and public welfare RA Public aspects of medicine RA0421 Public health. Hygiene. Preventive Medicine
spellingShingle	HV Social pathology. Social and public welfare RA Public aspects of medicine RA0421 Public health. Hygiene. Preventive Medicine Hajar Fauzan, Ahmad Mapping the human genetic architecture of COVID-19
description	The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
format	Article
author	Hajar Fauzan, Ahmad
author_facet	Hajar Fauzan, Ahmad
author_sort	Hajar Fauzan, Ahmad
title	Mapping the human genetic architecture of COVID-19
title_short	Mapping the human genetic architecture of COVID-19
title_full	Mapping the human genetic architecture of COVID-19
title_fullStr	Mapping the human genetic architecture of COVID-19
title_full_unstemmed	Mapping the human genetic architecture of COVID-19
title_sort	mapping the human genetic architecture of covid-19
publisher	Springer Nature
publishDate	2021
url	http://umpir.ump.edu.my/id/eprint/35374/3/Mapping%20the%20human%20genetic%20architecture%20of%20COVID.docx http://umpir.ump.edu.my/id/eprint/35374/ https://www.nature.com/articles/s41586-021-03767-x#Sec5 https://doi.org/10.1038/s41586-021-03767-x
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score	13.211869

Mapping the human genetic architecture of COVID-19

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