Cover Image

Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer

Thymoquinone, a bioactive component of the black seed of Nigella sativa, has received great attention from researchers due to its wide spectrum of pharmacological potentials. The present review highlights the molecular and functional mechanisms of thymoquinone serving as a therapeutic molecule comba...

Full description

Saved in:
Bibliographic Details
Main Authors: Tabassum, Shabana, Thakur, Vikram, Norhayati, Rosli, Solachuddin Jauhari, Arief Ichwan, Mishra, Puranjan, Wastuti Hidayati, Suriyah
Format: Article
Language:English
Published: Elsevier 2022
Subjects:
QA Mathematics
Online Access:http://umpir.ump.edu.my/id/eprint/35072/1/shabana%20Tabassum%20Gene%20Reports.pdf
http://umpir.ump.edu.my/id/eprint/35072/
http://www.elsevier.com/locate/genrep
https://doi.org/10.1016/j.genrep.2022.101600
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.ump.umpir.35072
record_format eprints
spelling my.ump.umpir.350722022-09-02T04:15:02Z http://umpir.ump.edu.my/id/eprint/35072/ Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer Tabassum, Shabana Thakur, Vikram Norhayati, Rosli Solachuddin Jauhari, Arief Ichwan Mishra, Puranjan Wastuti Hidayati, Suriyah QA Mathematics Thymoquinone, a bioactive component of the black seed of Nigella sativa, has received great attention from researchers due to its wide spectrum of pharmacological potentials. The present review highlights the molecular and functional mechanisms of thymoquinone serving as a therapeutic molecule combating oral and lung cancer by following the most recent literature. This summarized the latest nanotechnological interventions enhancing the efficacy and availability of thymoquinone in the in-vitro and in-vivo cancer models. Thymoquinone exhibits a significantly promising anticancer effect against oral and lung cancer by prompting intrinsic and extrinsic pathways of apoptosis through the activation of different caspases cascades, up and downregulation of apoptotic genes, antitumor cell proliferation, ROS regulation, etc. The accomplished insight into molecular and functional mechanisms of thymoquinone particularly combating oral and lung cancer will provide a better understanding and exploration of thymoquinone in an ethnopharmacological context. Elsevier 2022 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/35072/1/shabana%20Tabassum%20Gene%20Reports.pdf Tabassum, Shabana and Thakur, Vikram and Norhayati, Rosli and Solachuddin Jauhari, Arief Ichwan and Mishra, Puranjan and Wastuti Hidayati, Suriyah (2022) Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer. Gene Reports, 27 (101600). pp. 1-9. ISSN 2452-0144 http://www.elsevier.com/locate/genrep https://doi.org/10.1016/j.genrep.2022.101600
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QA Mathematics
spellingShingle QA Mathematics
Tabassum, Shabana
Thakur, Vikram
Norhayati, Rosli
Solachuddin Jauhari, Arief Ichwan
Mishra, Puranjan
Wastuti Hidayati, Suriyah
Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer
description Thymoquinone, a bioactive component of the black seed of Nigella sativa, has received great attention from researchers due to its wide spectrum of pharmacological potentials. The present review highlights the molecular and functional mechanisms of thymoquinone serving as a therapeutic molecule combating oral and lung cancer by following the most recent literature. This summarized the latest nanotechnological interventions enhancing the efficacy and availability of thymoquinone in the in-vitro and in-vivo cancer models. Thymoquinone exhibits a significantly promising anticancer effect against oral and lung cancer by prompting intrinsic and extrinsic pathways of apoptosis through the activation of different caspases cascades, up and downregulation of apoptotic genes, antitumor cell proliferation, ROS regulation, etc. The accomplished insight into molecular and functional mechanisms of thymoquinone particularly combating oral and lung cancer will provide a better understanding and exploration of thymoquinone in an ethnopharmacological context.
format Article
author Tabassum, Shabana
Thakur, Vikram
Norhayati, Rosli
Solachuddin Jauhari, Arief Ichwan
Mishra, Puranjan
Wastuti Hidayati, Suriyah
author_facet Tabassum, Shabana
Thakur, Vikram
Norhayati, Rosli
Solachuddin Jauhari, Arief Ichwan
Mishra, Puranjan
Wastuti Hidayati, Suriyah
author_sort Tabassum, Shabana
title Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer
title_short Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer
title_full Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer
title_fullStr Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer
title_full_unstemmed Therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer
title_sort therapeutic implications of thymoquinone and its molecular and functional mechanisms against oral and lung cancer
publisher Elsevier
publishDate 2022
url http://umpir.ump.edu.my/id/eprint/35072/1/shabana%20Tabassum%20Gene%20Reports.pdf
http://umpir.ump.edu.my/id/eprint/35072/
http://www.elsevier.com/locate/genrep
https://doi.org/10.1016/j.genrep.2022.101600
_version_ 1743107241701015552
score 13.211869

Similar Items