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Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology

Objective: Nanoemulsions consist of fine oil-in-water dispersions, with droplets covering the size range of 50–500 nm. Olive oil is frequently utilized in cosmetic and pharmaceutical topical product for its healing, protecting, and moisturizing properties due to its high fatty acid and antioxidant c...

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Main Authors: Wan Maznah, Wan Ishak, Mohd Hanif, Zulfakar
Format: Article
Language:English
Published: Innovare Academic Sciences Pvt Ltd 2022
Subjects:
Q Science (General)
RL Dermatology
RS Pharmacy and materia medica
Online Access:http://umpir.ump.edu.my/id/eprint/34864/1/Optimization%2C%20Development%20and%20Safety%20Evaluation%20Of%20Olive%20Oil%20Nanoemulsion%20For%20Topical%20Application.pdf
http://umpir.ump.edu.my/id/eprint/34864/
https://journals.innovareacademics.in/index.php/ajpcr/article/view/45964
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spelling my.ump.umpir.348642023-12-27T02:05:33Z http://umpir.ump.edu.my/id/eprint/34864/ Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology Wan Maznah, Wan Ishak Mohd Hanif, Zulfakar Q Science (General) RL Dermatology RS Pharmacy and materia medica Objective: Nanoemulsions consist of fine oil-in-water dispersions, with droplets covering the size range of 50–500 nm. Olive oil is frequently utilized in cosmetic and pharmaceutical topical product for its healing, protecting, and moisturizing properties due to its high fatty acid and antioxidant content. In the present work, a nanoemulsion composed of olive oil, Span 80 as surfactant, and Labrasol as cosurfactant was developed using a high-pressure homogenization method and was evaluated for its physicochemical characteristics. Methods: Response surface methodology was utilized to investigate the influence of the main nanoemulsion components: olive oil (X1), Span 80 (X2), and Labrasol (X3) on the droplet size (Y1) and polydispersity index (PDI) (Y2). A total of 17 formulations were generated by the Box-Behnken model. Results: The model was found to be highly significant with R2 values of 0.9833 and 0.9382 for droplet size and PDI, respectively. The optimized nanoemulsion presented the droplet size of 144.2±0.8 nm and PDI of 0.105±0.014. Span 80 seems to be the most influential factor that determines the droplet size as it has higher significant linear and interaction effects. The developed nanoemulsion was, further, evaluated with an in vivo skin irritancy study using the rat model. Conclusion: Results indicate that the developed nanoemulsion did not demonstrate any skin irritations in gross and histological examinations, suggesting that it is safe for topical applications. Innovare Academic Sciences Pvt Ltd 2022-09 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/34864/1/Optimization%2C%20Development%20and%20Safety%20Evaluation%20Of%20Olive%20Oil%20Nanoemulsion%20For%20Topical%20Application.pdf Wan Maznah, Wan Ishak and Mohd Hanif, Zulfakar (2022) Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology. Asian Journal of Pharmaceutical and Clinical Research, 15 (9). pp. 167-173. ISSN 0974-2441(print); 2455-3891(online). (Published) https://journals.innovareacademics.in/index.php/ajpcr/article/view/45964
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic Q Science (General)
RL Dermatology
RS Pharmacy and materia medica
spellingShingle Q Science (General)
RL Dermatology
RS Pharmacy and materia medica
Wan Maznah, Wan Ishak
Mohd Hanif, Zulfakar
Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology
description Objective: Nanoemulsions consist of fine oil-in-water dispersions, with droplets covering the size range of 50–500 nm. Olive oil is frequently utilized in cosmetic and pharmaceutical topical product for its healing, protecting, and moisturizing properties due to its high fatty acid and antioxidant content. In the present work, a nanoemulsion composed of olive oil, Span 80 as surfactant, and Labrasol as cosurfactant was developed using a high-pressure homogenization method and was evaluated for its physicochemical characteristics. Methods: Response surface methodology was utilized to investigate the influence of the main nanoemulsion components: olive oil (X1), Span 80 (X2), and Labrasol (X3) on the droplet size (Y1) and polydispersity index (PDI) (Y2). A total of 17 formulations were generated by the Box-Behnken model. Results: The model was found to be highly significant with R2 values of 0.9833 and 0.9382 for droplet size and PDI, respectively. The optimized nanoemulsion presented the droplet size of 144.2±0.8 nm and PDI of 0.105±0.014. Span 80 seems to be the most influential factor that determines the droplet size as it has higher significant linear and interaction effects. The developed nanoemulsion was, further, evaluated with an in vivo skin irritancy study using the rat model. Conclusion: Results indicate that the developed nanoemulsion did not demonstrate any skin irritations in gross and histological examinations, suggesting that it is safe for topical applications.
format Article
author Wan Maznah, Wan Ishak
Mohd Hanif, Zulfakar
author_facet Wan Maznah, Wan Ishak
Mohd Hanif, Zulfakar
author_sort Wan Maznah, Wan Ishak
title Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology
title_short Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology
title_full Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology
title_fullStr Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology
title_full_unstemmed Optimization, Development and Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology
title_sort optimization, development and safety evaluation of olive oil nanoemulsion for topical application: a response surface methodology
publisher Innovare Academic Sciences Pvt Ltd
publishDate 2022
url http://umpir.ump.edu.my/id/eprint/34864/1/Optimization%2C%20Development%20and%20Safety%20Evaluation%20Of%20Olive%20Oil%20Nanoemulsion%20For%20Topical%20Application.pdf
http://umpir.ump.edu.my/id/eprint/34864/
https://journals.innovareacademics.in/index.php/ajpcr/article/view/45964
_version_ 1822923955452772352
score 13.235796

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