Cover Image

Antibiotic purification by using metal ion affinity zeolite adsorbent

Antibiotics are chemical substances that can inhibit the growth of, and even destroy, harmful microorganisms. They are derived from special microorganisms or other living systems, and are produced on an industrial scale using a fermentation process. For a new antibiotic, manufacturers must be able t...

Full description

Saved in:
Bibliographic Details
Main Author: Saparudin, Wasimin
Format: Undergraduates Project Papers
Language:English
Published: 2010
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/3305/1/SAPARUDIN_BIN_WASIMIN.PDF
http://umpir.ump.edu.my/id/eprint/3305/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.ump.umpir.3305
record_format eprints
spelling my.ump.umpir.33052021-07-06T04:10:43Z http://umpir.ump.edu.my/id/eprint/3305/ Antibiotic purification by using metal ion affinity zeolite adsorbent Saparudin, Wasimin TP Chemical technology Antibiotics are chemical substances that can inhibit the growth of, and even destroy, harmful microorganisms. They are derived from special microorganisms or other living systems, and are produced on an industrial scale using a fermentation process. For a new antibiotic, manufacturers must be able to easily isolate it. For the isolation process, choosing a suitable adsorbent such as zeolite will result in high yield and a better quality of antibiotic product. Impurities from the fermentation process need to be isolate from the antibiotic. The purpose of this research is to use zeolite as an immobilized metal ion affinity stationary phase for antibiotic purification and to study the best parameter in purification process. In this research, zeolite was use as an immobilized metal ion affinity stationary phase for antibiotic purification. The method used in this research to purified the antibiotic was by using adsorption process. The antibiotic used in this research is Rfampicin. Zeolite H-Y and zeolite H-Beta that immobilized with metal ion was used as an adsorbent. Three parameters have been studied to elucidated the best condition for purification process, that is effect of contact time, effect of different pH and effect of different adsorbent. The samples were analyzed Using UV-VIS Spectrometer. The results show that the optimum contact time of adsorption of rifampicin is at 7 minutes. At this time, the zeolite has reached it limit to adsorb impurities. The maximum rifampicin adsorption is at pH 7. Effect of pH is related to pKa of the antibiotic. The third parameter studied shows that the best adsorbent is zeolite that immobilized with metal nikel. From the data and supported theories by various authors, it can be conclude that studied the different condition in adsorption process have a significant effect on antibiotic purification. 2010-04 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/3305/1/SAPARUDIN_BIN_WASIMIN.PDF Saparudin, Wasimin (2010) Antibiotic purification by using metal ion affinity zeolite adsorbent. Faculty of Chemical and Natural Resources Engineering , Universiti Malaysia Pahang .
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Saparudin, Wasimin
Antibiotic purification by using metal ion affinity zeolite adsorbent
description Antibiotics are chemical substances that can inhibit the growth of, and even destroy, harmful microorganisms. They are derived from special microorganisms or other living systems, and are produced on an industrial scale using a fermentation process. For a new antibiotic, manufacturers must be able to easily isolate it. For the isolation process, choosing a suitable adsorbent such as zeolite will result in high yield and a better quality of antibiotic product. Impurities from the fermentation process need to be isolate from the antibiotic. The purpose of this research is to use zeolite as an immobilized metal ion affinity stationary phase for antibiotic purification and to study the best parameter in purification process. In this research, zeolite was use as an immobilized metal ion affinity stationary phase for antibiotic purification. The method used in this research to purified the antibiotic was by using adsorption process. The antibiotic used in this research is Rfampicin. Zeolite H-Y and zeolite H-Beta that immobilized with metal ion was used as an adsorbent. Three parameters have been studied to elucidated the best condition for purification process, that is effect of contact time, effect of different pH and effect of different adsorbent. The samples were analyzed Using UV-VIS Spectrometer. The results show that the optimum contact time of adsorption of rifampicin is at 7 minutes. At this time, the zeolite has reached it limit to adsorb impurities. The maximum rifampicin adsorption is at pH 7. Effect of pH is related to pKa of the antibiotic. The third parameter studied shows that the best adsorbent is zeolite that immobilized with metal nikel. From the data and supported theories by various authors, it can be conclude that studied the different condition in adsorption process have a significant effect on antibiotic purification.
format Undergraduates Project Papers
author Saparudin, Wasimin
author_facet Saparudin, Wasimin
author_sort Saparudin, Wasimin
title Antibiotic purification by using metal ion affinity zeolite adsorbent
title_short Antibiotic purification by using metal ion affinity zeolite adsorbent
title_full Antibiotic purification by using metal ion affinity zeolite adsorbent
title_fullStr Antibiotic purification by using metal ion affinity zeolite adsorbent
title_full_unstemmed Antibiotic purification by using metal ion affinity zeolite adsorbent
title_sort antibiotic purification by using metal ion affinity zeolite adsorbent
publishDate 2010
url http://umpir.ump.edu.my/id/eprint/3305/1/SAPARUDIN_BIN_WASIMIN.PDF
http://umpir.ump.edu.my/id/eprint/3305/
_version_ 1705056916527382528
score 13.211869

Similar Items