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Thymoquinone and its pharmacological perspective: A review

Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally and clinically used natural medicine. The diverse pharmacological properties of TQ have been identified including antimicrobial, antihistamine, antioxidant effects, immunomodulator, and anticancer activities....

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Main Authors: Tabassum, Shabana, Norhayati, Rosli, Arief Ichwan, Solachuddin Jauhari, Mishrad, Puranjan
Format: Article
Language:English
Published: Elsevier 2021
Subjects:
QA Mathematics
RC Internal medicine
Online Access:http://umpir.ump.edu.my/id/eprint/32907/1/Pharmacological%20Research%20-%20TQ%20and%20Its%20Pharmacological%20Perspective%20A%20Review.pdf
http://umpir.ump.edu.my/id/eprint/32907/
https://doi.org/10.1016/j.prmcm.2021.100020
https://doi.org/10.1016/j.prmcm.2021.100020
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spelling my.ump.umpir.329072022-06-17T03:55:41Z http://umpir.ump.edu.my/id/eprint/32907/ Thymoquinone and its pharmacological perspective: A review Tabassum, Shabana Norhayati, Rosli Arief Ichwan, Solachuddin Jauhari Mishrad, Puranjan QA Mathematics RC Internal medicine Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally and clinically used natural medicine. The diverse pharmacological properties of TQ have been identified including antimicrobial, antihistamine, antioxidant effects, immunomodulator, and anticancer activities. In this review, investigations regarding the effects of TQ in oxidative stress, immunomodulation, and various type of cancer have been reviewed based on the available relevant literature. TQ-based induction of the immune system by modulating different inflammatory mediators i.e., cytokines, leukins, interleukins, interferons, and other immune cells have been reviewed here. Several studies signified remarkable anticancer potentials of TQ depending upon its concentration and type of cancer cell. Conclusively, understanding pharmacological activities of TQ its molecular mechanism could help researchers to develop a potent analog of well-established chemotherapeutic drugs in clinical trials. Elsevier 2021-12 Article PeerReviewed pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/32907/1/Pharmacological%20Research%20-%20TQ%20and%20Its%20Pharmacological%20Perspective%20A%20Review.pdf Tabassum, Shabana and Norhayati, Rosli and Arief Ichwan, Solachuddin Jauhari and Mishrad, Puranjan (2021) Thymoquinone and its pharmacological perspective: A review. Pharmacological Research - Modern Chinese Medicine, 1 (100020). pp. 1-10. ISSN 2667-1425 https://doi.org/10.1016/j.prmcm.2021.100020 https://doi.org/10.1016/j.prmcm.2021.100020
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QA Mathematics
RC Internal medicine
spellingShingle QA Mathematics
RC Internal medicine
Tabassum, Shabana
Norhayati, Rosli
Arief Ichwan, Solachuddin Jauhari
Mishrad, Puranjan
Thymoquinone and its pharmacological perspective: A review
description Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally and clinically used natural medicine. The diverse pharmacological properties of TQ have been identified including antimicrobial, antihistamine, antioxidant effects, immunomodulator, and anticancer activities. In this review, investigations regarding the effects of TQ in oxidative stress, immunomodulation, and various type of cancer have been reviewed based on the available relevant literature. TQ-based induction of the immune system by modulating different inflammatory mediators i.e., cytokines, leukins, interleukins, interferons, and other immune cells have been reviewed here. Several studies signified remarkable anticancer potentials of TQ depending upon its concentration and type of cancer cell. Conclusively, understanding pharmacological activities of TQ its molecular mechanism could help researchers to develop a potent analog of well-established chemotherapeutic drugs in clinical trials.
format Article
author Tabassum, Shabana
Norhayati, Rosli
Arief Ichwan, Solachuddin Jauhari
Mishrad, Puranjan
author_facet Tabassum, Shabana
Norhayati, Rosli
Arief Ichwan, Solachuddin Jauhari
Mishrad, Puranjan
author_sort Tabassum, Shabana
title Thymoquinone and its pharmacological perspective: A review
title_short Thymoquinone and its pharmacological perspective: A review
title_full Thymoquinone and its pharmacological perspective: A review
title_fullStr Thymoquinone and its pharmacological perspective: A review
title_full_unstemmed Thymoquinone and its pharmacological perspective: A review
title_sort thymoquinone and its pharmacological perspective: a review
publisher Elsevier
publishDate 2021
url http://umpir.ump.edu.my/id/eprint/32907/1/Pharmacological%20Research%20-%20TQ%20and%20Its%20Pharmacological%20Perspective%20A%20Review.pdf
http://umpir.ump.edu.my/id/eprint/32907/
https://doi.org/10.1016/j.prmcm.2021.100020
https://doi.org/10.1016/j.prmcm.2021.100020
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score 13.211869

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