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Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl

Objective: To study the aphrodisiac potential of Polyalthia (P.) bullata in fowl. Methods: In this study, testosterone, as an indicator of the aphrodisiac potential of P. bullata, was investigated for its release from TM3 Leydig cells grown in vitro and in 4 fowls given capsules containing P. bullat...

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Main Authors: Jaya Vejayan, Palliah, Yasmin Amira, Che Yahya, Chakravarthi, Srikumar, Halijah, Ibrahim, Aida, Yun
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/31734/1/Aphrodisiac%20potential%20of%20polyalthia%20bullata%20%28Tongkat%20Ali%29%20in%20fowl.pdf
http://umpir.ump.edu.my/id/eprint/31734/
https://doi.org/10.4103/2305-0500.311615
https://doi.org/10.4103/2305-0500.311615
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spelling my.ump.umpir.317342021-07-30T08:00:30Z http://umpir.ump.edu.my/id/eprint/31734/ Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl Jaya Vejayan, Palliah Yasmin Amira, Che Yahya Chakravarthi, Srikumar Halijah, Ibrahim Aida, Yun TP Chemical technology Objective: To study the aphrodisiac potential of Polyalthia (P.) bullata in fowl. Methods: In this study, testosterone, as an indicator of the aphrodisiac potential of P. bullata, was investigated for its release from TM3 Leydig cells grown in vitro and in 4 fowls given capsules containing P. bullata at a dose of 10 mg in each capsule twice a day, for 50 days. In the latter in vivo evaluation, mating behaviours were additionally determined after the treated fowls were released to the individual hens, and their testes and liver were dissected for histological examinations. Blood drawn from the fowls was assessed for any changes in diagnostic parameters. Results: In the in vitro test (TM3 Leydig cells), P. bullata was able to increase testosterone to 0.48 nmol/L within 72 h of incubation, compared to the untreated control with only 0.18 nmol/L, i.e., an increase of 170%. In the in vivo test, outcomes in the fowls dosed with P. bullata showed similar positive elevations of testosterone to (9.72±1.10) nmol/L in comparison to the controls that showed a level of only (4.05±0.84) nmol/L. Total frequencies of mating behaviours were observed (wing flapping, body shakes, crowing and beak pecking) to be 23 counts for the test compared to only 15 for the control fowls. Histological examination of the male reproductive organs provided evidence of testosterone boosting based on an observable increase in the activity at the seminiferous tubules of testis tissues without any damaging effects, compared to the controls. In the nine diagnostic blood parameters assessed, including alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase, none was remarkably elevated compared to the controls. The histological changes in the liver were not severe and mainly consisted of only localized moderate but recoverable obstructions and swellings of the vessels and tubules. Conclusions: P. bullata is able to boost testosterone both in vitro and in vivo, with no acute toxicities. Wolters Kluwer Medknow Publications 2021-03-01 Article PeerReviewed pdf en cc_by_nc_sa_4 http://umpir.ump.edu.my/id/eprint/31734/1/Aphrodisiac%20potential%20of%20polyalthia%20bullata%20%28Tongkat%20Ali%29%20in%20fowl.pdf Jaya Vejayan, Palliah and Yasmin Amira, Che Yahya and Chakravarthi, Srikumar and Halijah, Ibrahim and Aida, Yun (2021) Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl. Asian Pacific Journal of Reproduction, 10 (2). 75 -81. ISSN 2305-0500 https://doi.org/10.4103/2305-0500.311615 https://doi.org/10.4103/2305-0500.311615
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Jaya Vejayan, Palliah
Yasmin Amira, Che Yahya
Chakravarthi, Srikumar
Halijah, Ibrahim
Aida, Yun
Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
description Objective: To study the aphrodisiac potential of Polyalthia (P.) bullata in fowl. Methods: In this study, testosterone, as an indicator of the aphrodisiac potential of P. bullata, was investigated for its release from TM3 Leydig cells grown in vitro and in 4 fowls given capsules containing P. bullata at a dose of 10 mg in each capsule twice a day, for 50 days. In the latter in vivo evaluation, mating behaviours were additionally determined after the treated fowls were released to the individual hens, and their testes and liver were dissected for histological examinations. Blood drawn from the fowls was assessed for any changes in diagnostic parameters. Results: In the in vitro test (TM3 Leydig cells), P. bullata was able to increase testosterone to 0.48 nmol/L within 72 h of incubation, compared to the untreated control with only 0.18 nmol/L, i.e., an increase of 170%. In the in vivo test, outcomes in the fowls dosed with P. bullata showed similar positive elevations of testosterone to (9.72±1.10) nmol/L in comparison to the controls that showed a level of only (4.05±0.84) nmol/L. Total frequencies of mating behaviours were observed (wing flapping, body shakes, crowing and beak pecking) to be 23 counts for the test compared to only 15 for the control fowls. Histological examination of the male reproductive organs provided evidence of testosterone boosting based on an observable increase in the activity at the seminiferous tubules of testis tissues without any damaging effects, compared to the controls. In the nine diagnostic blood parameters assessed, including alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase, none was remarkably elevated compared to the controls. The histological changes in the liver were not severe and mainly consisted of only localized moderate but recoverable obstructions and swellings of the vessels and tubules. Conclusions: P. bullata is able to boost testosterone both in vitro and in vivo, with no acute toxicities.
format Article
author Jaya Vejayan, Palliah
Yasmin Amira, Che Yahya
Chakravarthi, Srikumar
Halijah, Ibrahim
Aida, Yun
author_facet Jaya Vejayan, Palliah
Yasmin Amira, Che Yahya
Chakravarthi, Srikumar
Halijah, Ibrahim
Aida, Yun
author_sort Jaya Vejayan, Palliah
title Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_short Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_full Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_fullStr Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_full_unstemmed Aphrodisiac potential of Polyalthia bullata (Tongkat Ali) in fowl
title_sort aphrodisiac potential of polyalthia bullata (tongkat ali) in fowl
publisher Wolters Kluwer Medknow Publications
publishDate 2021
url http://umpir.ump.edu.my/id/eprint/31734/1/Aphrodisiac%20potential%20of%20polyalthia%20bullata%20%28Tongkat%20Ali%29%20in%20fowl.pdf
http://umpir.ump.edu.my/id/eprint/31734/
https://doi.org/10.4103/2305-0500.311615
https://doi.org/10.4103/2305-0500.311615
_version_ 1706957262495416320
score 13.211869

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