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Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development

With the long-term goal of developing an ultra-sensitive microcantilever-based biosensor for versatile biomarker detection, new controlled bioreceptor-analytes systems are being explored to overcome the disadvantages of conventional ones. Gold (Au) microwires have been used as a probe to overcome th...

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Main Authors: Nurul Akmal, Che Lah, Gray, Robert, Trigueros, Sonia
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
TK Electrical engineering. Electronics Nuclear engineering
TS Manufactures
Online Access:http://umpir.ump.edu.my/id/eprint/31405/1/Synthesis%20characterisation%20and%20cytotoxicity%20of%20gold%20microwires%20for%20ultra.pdf
http://umpir.ump.edu.my/id/eprint/31405/
https://doi.org/10.1186/s12934-020-01478-y
https://doi.org/10.1186/s12934-020-01478-y
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spelling my.ump.umpir.314052021-06-30T05:06:20Z http://umpir.ump.edu.my/id/eprint/31405/ Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development Nurul Akmal, Che Lah Gray, Robert Trigueros, Sonia TK Electrical engineering. Electronics Nuclear engineering TS Manufactures With the long-term goal of developing an ultra-sensitive microcantilever-based biosensor for versatile biomarker detection, new controlled bioreceptor-analytes systems are being explored to overcome the disadvantages of conventional ones. Gold (Au) microwires have been used as a probe to overcome the tolerance problem that occurs in response to changes in environmental conditions. However, the cytotoxicity of Au microwires is still unclear. Here, we examined the cytotoxicity of Au microwires systems using both commercial and as-synthesised Au microwires. In vitro experiments show that commercial Au microwires with an average quoted length of 5.6 µm are highly toxic against Gram-negative Escherichia coli (E. coli) at 50 µg/mL. However, this toxicity is due to the presence of CTAB surfactant not by the microwires. Conversely, the as-synthesised Au microwires show non-cytotoxicity even at the maximum viable concentration (330 µg/mL). These findings may lead to the development of potentially life-saving cytotoxicity-free biosensors for an early diagnostic of potential diseases. BioMed Central Ltd 2021-02-17 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/31405/1/Synthesis%20characterisation%20and%20cytotoxicity%20of%20gold%20microwires%20for%20ultra.pdf Nurul Akmal, Che Lah and Gray, Robert and Trigueros, Sonia (2021) Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development. Microbial Cell Factories, 20 (1). pp. 1-11. ISSN 1475-2859 https://doi.org/10.1186/s12934-020-01478-y https://doi.org/10.1186/s12934-020-01478-y
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TK Electrical engineering. Electronics Nuclear engineering
TS Manufactures
spellingShingle TK Electrical engineering. Electronics Nuclear engineering
TS Manufactures
Nurul Akmal, Che Lah
Gray, Robert
Trigueros, Sonia
Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development
description With the long-term goal of developing an ultra-sensitive microcantilever-based biosensor for versatile biomarker detection, new controlled bioreceptor-analytes systems are being explored to overcome the disadvantages of conventional ones. Gold (Au) microwires have been used as a probe to overcome the tolerance problem that occurs in response to changes in environmental conditions. However, the cytotoxicity of Au microwires is still unclear. Here, we examined the cytotoxicity of Au microwires systems using both commercial and as-synthesised Au microwires. In vitro experiments show that commercial Au microwires with an average quoted length of 5.6 µm are highly toxic against Gram-negative Escherichia coli (E. coli) at 50 µg/mL. However, this toxicity is due to the presence of CTAB surfactant not by the microwires. Conversely, the as-synthesised Au microwires show non-cytotoxicity even at the maximum viable concentration (330 µg/mL). These findings may lead to the development of potentially life-saving cytotoxicity-free biosensors for an early diagnostic of potential diseases.
format Article
author Nurul Akmal, Che Lah
Gray, Robert
Trigueros, Sonia
author_facet Nurul Akmal, Che Lah
Gray, Robert
Trigueros, Sonia
author_sort Nurul Akmal, Che Lah
title Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development
title_short Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development
title_full Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development
title_fullStr Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development
title_full_unstemmed Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development
title_sort synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development
publisher BioMed Central Ltd
publishDate 2021
url http://umpir.ump.edu.my/id/eprint/31405/1/Synthesis%20characterisation%20and%20cytotoxicity%20of%20gold%20microwires%20for%20ultra.pdf
http://umpir.ump.edu.my/id/eprint/31405/
https://doi.org/10.1186/s12934-020-01478-y
https://doi.org/10.1186/s12934-020-01478-y
_version_ 1705057023512543232
score 13.211869

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