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Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.

In this study, a simplex-centroid mixture design using design of experiment (DOE) software was implemented to evaluate the effect of biopolymers as excipients, which are hydroxypropyl methylcellulose, and alginate, on the gastrointestinal tolerance of probiotic tablet containing Saccharomyces boular...

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Main Authors: Mohd Akmal, Azhar, Mimi Sakinah, Abdul Munaim
Format: Article
Language:English
Published: Taylor & Francis 2020
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/30455/1/azhar2020.pdf
http://umpir.ump.edu.my/id/eprint/30455/
https://www.tandfonline.com/loi/iddi20
https://doi.org/10.1080/03639045.2020.1862176
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spelling my.ump.umpir.304552021-01-15T04:06:19Z http://umpir.ump.edu.my/id/eprint/30455/ Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. Mohd Akmal, Azhar Mimi Sakinah, Abdul Munaim TP Chemical technology In this study, a simplex-centroid mixture design using design of experiment (DOE) software was implemented to evaluate the effect of biopolymers as excipients, which are hydroxypropyl methylcellulose, and alginate, on the gastrointestinal tolerance of probiotic tablet containing Saccharomyces boulardii. Microbial viability and dissolution time were used to evaluate the ideal formulation made using 39.01% carboxymethylcellulose and 60.99% alginate as excipients, which protected the probiotics from the acidic condition in the stomach with good dissolution time. The formulated probiotic tablet is more stable in terms of viability when stored at 4 C compared to room temperature. However, the viability remains above 106 CFU/tablet after six months of storage at room temperature. This study shows that the simplex-centroid mixture design is valid and can be used to formulate probiotic tablets that possess gastrointestinal tolerance. This study can lead to the development of commercial production of probiotic yeast tablets with gastrointestinal tolerance. Taylor & Francis 2020-12-16 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/30455/1/azhar2020.pdf Mohd Akmal, Azhar and Mimi Sakinah, Abdul Munaim (2020) Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture. Drug Development and Industrial Pharmacy. pp. 1-9. ISSN 0363-9045 https://www.tandfonline.com/loi/iddi20 https://doi.org/10.1080/03639045.2020.1862176
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Mohd Akmal, Azhar
Mimi Sakinah, Abdul Munaim
Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.
description In this study, a simplex-centroid mixture design using design of experiment (DOE) software was implemented to evaluate the effect of biopolymers as excipients, which are hydroxypropyl methylcellulose, and alginate, on the gastrointestinal tolerance of probiotic tablet containing Saccharomyces boulardii. Microbial viability and dissolution time were used to evaluate the ideal formulation made using 39.01% carboxymethylcellulose and 60.99% alginate as excipients, which protected the probiotics from the acidic condition in the stomach with good dissolution time. The formulated probiotic tablet is more stable in terms of viability when stored at 4 C compared to room temperature. However, the viability remains above 106 CFU/tablet after six months of storage at room temperature. This study shows that the simplex-centroid mixture design is valid and can be used to formulate probiotic tablets that possess gastrointestinal tolerance. This study can lead to the development of commercial production of probiotic yeast tablets with gastrointestinal tolerance.
format Article
author Mohd Akmal, Azhar
Mimi Sakinah, Abdul Munaim
author_facet Mohd Akmal, Azhar
Mimi Sakinah, Abdul Munaim
author_sort Mohd Akmal, Azhar
title Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.
title_short Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.
title_full Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.
title_fullStr Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.
title_full_unstemmed Design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.
title_sort design and optimization of a probiotic tablet for gastrointestinal tolerance by a simplex-centroid mixture.
publisher Taylor & Francis
publishDate 2020
url http://umpir.ump.edu.my/id/eprint/30455/1/azhar2020.pdf
http://umpir.ump.edu.my/id/eprint/30455/
https://www.tandfonline.com/loi/iddi20
https://doi.org/10.1080/03639045.2020.1862176
_version_ 1690371143469367296
score 13.211869

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