Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis
A series of aminated- (1–9) and sulfonamide-containing diarylpentadienones (10–18) were synthesized, structurally characterized, and evaluated for their in vitro anti-diabetic potential on α-glucosidase and DPP-4 enzymes. It was found that all the new molecules were nonassociated PAINS compounds. Th...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Academic Press Inc.
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/30212/1/Development%20of%20diarylpentadienone%20analogues%20as%20alpha-glucosidase%20inhibitor.pdf http://umpir.ump.edu.my/id/eprint/30212/2/Development%20of%20diarylpentadienone%20analogues%20as%20alpha-glucosidase%20inhibitor_FULL.pdf http://umpir.ump.edu.my/id/eprint/30212/ https://doi.org/10.1016/j.bioorg.2020.104277 https://doi.org/10.1016/j.bioorg.2020.104277 |
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