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Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin

The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium al...

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Main Authors: Hassani, Abdelkader, Mahmood, Syed, Enezei, H. H., Siti Aslina, Hussain, Hamad, Hamad Ali, Aldoghachi, Ahmed Faris, Hagar, Abdullah, Doolaanea, Abd Almonem, Ibrahim, Wisam Nabeel
Format: Article
Language:English
Published: MDPI - Open Access Publishing 2020
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TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/28559/1/Formulation%2C%20characterization%20and%20biological%20activity%20screening%20of%20sodium.pdf
http://umpir.ump.edu.my/id/eprint/28559/
https://doi.org/10.3390/molecules25092244
https://doi.org/10.3390/molecules25092244
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spelling my.ump.umpir.285592021-02-03T03:56:36Z http://umpir.ump.edu.my/id/eprint/28559/ Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin Hassani, Abdelkader Mahmood, Syed Enezei, H. H. Siti Aslina, Hussain Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel TP Chemical technology The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy. MDPI - Open Access Publishing 2020-05-01 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/28559/1/Formulation%2C%20characterization%20and%20biological%20activity%20screening%20of%20sodium.pdf Hassani, Abdelkader and Mahmood, Syed and Enezei, H. H. and Siti Aslina, Hussain and Hamad, Hamad Ali and Aldoghachi, Ahmed Faris and Hagar, Abdullah and Doolaanea, Abd Almonem and Ibrahim, Wisam Nabeel (2020) Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin. Molecules, 25 (9). pp. 1-21. ISSN 1420-3049 (print); 1420-3049 (online) https://doi.org/10.3390/molecules25092244 https://doi.org/10.3390/molecules25092244
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Hassani, Abdelkader
Mahmood, Syed
Enezei, H. H.
Siti Aslina, Hussain
Hamad, Hamad Ali
Aldoghachi, Ahmed Faris
Hagar, Abdullah
Doolaanea, Abd Almonem
Ibrahim, Wisam Nabeel
Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin
description The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy.
format Article
author Hassani, Abdelkader
Mahmood, Syed
Enezei, H. H.
Siti Aslina, Hussain
Hamad, Hamad Ali
Aldoghachi, Ahmed Faris
Hagar, Abdullah
Doolaanea, Abd Almonem
Ibrahim, Wisam Nabeel
author_facet Hassani, Abdelkader
Mahmood, Syed
Enezei, H. H.
Siti Aslina, Hussain
Hamad, Hamad Ali
Aldoghachi, Ahmed Faris
Hagar, Abdullah
Doolaanea, Abd Almonem
Ibrahim, Wisam Nabeel
author_sort Hassani, Abdelkader
title Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin
title_short Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin
title_full Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin
title_fullStr Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin
title_full_unstemmed Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin
title_sort formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin
publisher MDPI - Open Access Publishing
publishDate 2020
url http://umpir.ump.edu.my/id/eprint/28559/1/Formulation%2C%20characterization%20and%20biological%20activity%20screening%20of%20sodium.pdf
http://umpir.ump.edu.my/id/eprint/28559/
https://doi.org/10.3390/molecules25092244
https://doi.org/10.3390/molecules25092244
_version_ 1691733256093827072
score 13.211869

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