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Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship

(−)-Colchicine, an anti-microtubulin polymerization agent, is a valuable medication and the drug of choice for gout, Behçet’s disease and familial Mediterranean fever. It has a narrow therapeutic index due to its high toxicity towards normal cells. Nonetheless, numerous (−)-colchicine derivatives ha...

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Bibliographic Details
Main Authors: Ghawanmeh, Abdullah A., Al-Bajalan, Hussein M., Mackeen, Mukram Mohamed, Alali, Feras Q., K. F., Chong
Format: Article
Language:English
Published: Elsevier 2019
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/26482/1/Recent%20developments%20on%20%28%E2%88%92%29-colchicine%20derivatives%20_%20synthesis%20and%20structure.pdf
http://umpir.ump.edu.my/id/eprint/26482/
https://doi.org/10.1016/j.ejmech.2019.111788
https://doi.org/10.1016/j.ejmech.2019.111788
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http://umpir.ump.edu.my/id/eprint/26482/1/Recent%20developments%20on%20%28%E2%88%92%29-colchicine%20derivatives%20_%20synthesis%20and%20structure.pdf
http://umpir.ump.edu.my/id/eprint/26482/
https://doi.org/10.1016/j.ejmech.2019.111788
https://doi.org/10.1016/j.ejmech.2019.111788

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