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Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling

A pharmaceutical importance compound, mesoxalic acid, can be produced through selective oxidation of glycerol using laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system. Since mesoxalic acid is the fourth product in the serial oxidation, identification of the reaction conditions and its’ kinetic to m...

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Main Authors: Hong, Chi Shein, Chin, S. Y., Cheng, C. K., Chua, Gek Kee
Format: Article
Language:English
Published: Taylor & Francis 2019
Subjects:
QD Chemistry
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/26220/1/Selective%20oxidation%20of%20glycerol%20to%20mesoxalic%20acid.pdf
http://umpir.ump.edu.my/id/eprint/26220/
https://doi.org/10.1080/00986445.2019.1566128
https://doi.org/10.1080/00986445.2019.1566128
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spelling my.ump.umpir.262202019-12-06T09:01:54Z http://umpir.ump.edu.my/id/eprint/26220/ Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling Hong, Chi Shein Chin, S. Y. Cheng, C. K. Chua, Gek Kee QD Chemistry TP Chemical technology A pharmaceutical importance compound, mesoxalic acid, can be produced through selective oxidation of glycerol using laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system. Since mesoxalic acid is the fourth product in the serial oxidation, identification of the reaction conditions and its’ kinetic to maximize the production is essential. Hence, the objective of this study is to examine the effects of process conditions on the distribution of the products and the kinetic. Mesoxalic acid attained was 0.0712 M (>200% of control) at 19 °C, pH 5.5, 1:3 of glycerol/TEMPO ratio and TEMPO/laccase ratio of 9:3. To conclude, a moderate temperature that preserves the activity of laccase would favor the formation of mesoxalic acid. The serial chemical reactions could be expressed by a power law rate obtained via MATLAB through fitting of the experimental kinetic data. Oxidising from tartronic acid to mesoxalic acid was found to require higher activation energy (25.06 kJ/mol) as compared to other steps. Taylor & Francis 2019-02-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26220/1/Selective%20oxidation%20of%20glycerol%20to%20mesoxalic%20acid.pdf Hong, Chi Shein and Chin, S. Y. and Cheng, C. K. and Chua, Gek Kee (2019) Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling. Chemical Engineering Communications, 206 (12). pp. 1645-1660. ISSN 0098-6445 (print); 1563-5201 (online). (Published) https://doi.org/10.1080/00986445.2019.1566128 https://doi.org/10.1080/00986445.2019.1566128
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QD Chemistry
TP Chemical technology
spellingShingle QD Chemistry
TP Chemical technology
Hong, Chi Shein
Chin, S. Y.
Cheng, C. K.
Chua, Gek Kee
Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling
description A pharmaceutical importance compound, mesoxalic acid, can be produced through selective oxidation of glycerol using laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system. Since mesoxalic acid is the fourth product in the serial oxidation, identification of the reaction conditions and its’ kinetic to maximize the production is essential. Hence, the objective of this study is to examine the effects of process conditions on the distribution of the products and the kinetic. Mesoxalic acid attained was 0.0712 M (>200% of control) at 19 °C, pH 5.5, 1:3 of glycerol/TEMPO ratio and TEMPO/laccase ratio of 9:3. To conclude, a moderate temperature that preserves the activity of laccase would favor the formation of mesoxalic acid. The serial chemical reactions could be expressed by a power law rate obtained via MATLAB through fitting of the experimental kinetic data. Oxidising from tartronic acid to mesoxalic acid was found to require higher activation energy (25.06 kJ/mol) as compared to other steps.
format Article
author Hong, Chi Shein
Chin, S. Y.
Cheng, C. K.
Chua, Gek Kee
author_facet Hong, Chi Shein
Chin, S. Y.
Cheng, C. K.
Chua, Gek Kee
author_sort Hong, Chi Shein
title Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling
title_short Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling
title_full Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling
title_fullStr Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling
title_full_unstemmed Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling
title_sort selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-n-oxyl system : effect of process conditions and the kinetic modeling
publisher Taylor & Francis
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/26220/1/Selective%20oxidation%20of%20glycerol%20to%20mesoxalic%20acid.pdf
http://umpir.ump.edu.my/id/eprint/26220/
https://doi.org/10.1080/00986445.2019.1566128
https://doi.org/10.1080/00986445.2019.1566128
_version_ 1822921066012475392
score 13.235796

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