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Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines

Glycosaminoglycans (GAGs) are long unbranched polysaccharide that composed of repeating disaccharide units. They are classified into heparan sulfate (HS), heparin, chondroitin sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS) and hyaluronic acid (HA). During the last decade, demand of GAGs w...

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Main Authors: Nurul Haida, Idrus, Nina Suhaity, Azmi, Che Nur Mazadillina, Che Zahari, J. A. Ichwan, Solachuddin
Format: Conference or Workshop Item
Language:English
English
Published: Trans Tech Publications Ltd 2019
Subjects:
Q Science (General)
TD Environmental technology. Sanitary engineering
Online Access:http://umpir.ump.edu.my/id/eprint/25474/1/Nurul%20Haida%20-%20SISTEC%202019%20-15%20July%202019.doc
http://umpir.ump.edu.my/id/eprint/25474/3/15.1%20Cytotoxic%20and%20anti-%20inflammatory%20activities%20of%20glycosaminoglycans%20%28GAGs%29.pdf
http://umpir.ump.edu.my/id/eprint/25474/
https://doi.org/10.4028/www.scientific.net/MSF.981.258
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spelling my.ump.umpir.254742023-05-17T04:33:47Z http://umpir.ump.edu.my/id/eprint/25474/ Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines Nurul Haida, Idrus Nina Suhaity, Azmi Che Nur Mazadillina, Che Zahari J. A. Ichwan, Solachuddin Q Science (General) TD Environmental technology. Sanitary engineering Glycosaminoglycans (GAGs) are long unbranched polysaccharide that composed of repeating disaccharide units. They are classified into heparan sulfate (HS), heparin, chondroitin sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS) and hyaluronic acid (HA). During the last decade, demand of GAGs were getting increased due to their potential uses. Vertebrate animal, commonly cartilaginous mammalian tissue, were potential producer of GAGs and have the higher number of biological activities extracted from sea bass waste. Sea bass waste from Lates calcarifer was used as the raw material to extract crude GAGs. Different part of sea bass waste such as, gills, viscera and air bladders were used. The higher content of crude GAGs in sea bass waste was used in cytotoxic and inflammatory study. Different concentration of extract GAGs from gills were used ranging between 0.16-20 mg/mL. GAGs from sea bass waste (gills) showed dose-dependent cytotoxic activity towards MCF-7 cell line in lower concentration. Meanwhile, for anti-inflammatory study GAGs from sea bass waste (gills) showed dose-dependent manner and also reduce NO production in LPS-stimulated cells. This research study concluded that, GAGs from sea bass waste are the alternative source that can be used for cancer and inflammation study. Trans Tech Publications Ltd 2019-07-19 Conference or Workshop Item NonPeerReviewed text en http://umpir.ump.edu.my/id/eprint/25474/1/Nurul%20Haida%20-%20SISTEC%202019%20-15%20July%202019.doc pdf en http://umpir.ump.edu.my/id/eprint/25474/3/15.1%20Cytotoxic%20and%20anti-%20inflammatory%20activities%20of%20glycosaminoglycans%20%28GAGs%29.pdf Nurul Haida, Idrus and Nina Suhaity, Azmi and Che Nur Mazadillina, Che Zahari and J. A. Ichwan, Solachuddin (2019) Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines. In: Symposium on Industrial Science and Technology, SISTEC 2019, 22-23 Aug. 2019 , Kuantan, Malaysia. pp. 258-264., 981. (Submitted) https://doi.org/10.4028/www.scientific.net/MSF.981.258
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
English
topic Q Science (General)
TD Environmental technology. Sanitary engineering
spellingShingle Q Science (General)
TD Environmental technology. Sanitary engineering
Nurul Haida, Idrus
Nina Suhaity, Azmi
Che Nur Mazadillina, Che Zahari
J. A. Ichwan, Solachuddin
Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines
description Glycosaminoglycans (GAGs) are long unbranched polysaccharide that composed of repeating disaccharide units. They are classified into heparan sulfate (HS), heparin, chondroitin sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS) and hyaluronic acid (HA). During the last decade, demand of GAGs were getting increased due to their potential uses. Vertebrate animal, commonly cartilaginous mammalian tissue, were potential producer of GAGs and have the higher number of biological activities extracted from sea bass waste. Sea bass waste from Lates calcarifer was used as the raw material to extract crude GAGs. Different part of sea bass waste such as, gills, viscera and air bladders were used. The higher content of crude GAGs in sea bass waste was used in cytotoxic and inflammatory study. Different concentration of extract GAGs from gills were used ranging between 0.16-20 mg/mL. GAGs from sea bass waste (gills) showed dose-dependent cytotoxic activity towards MCF-7 cell line in lower concentration. Meanwhile, for anti-inflammatory study GAGs from sea bass waste (gills) showed dose-dependent manner and also reduce NO production in LPS-stimulated cells. This research study concluded that, GAGs from sea bass waste are the alternative source that can be used for cancer and inflammation study.
format Conference or Workshop Item
author Nurul Haida, Idrus
Nina Suhaity, Azmi
Che Nur Mazadillina, Che Zahari
J. A. Ichwan, Solachuddin
author_facet Nurul Haida, Idrus
Nina Suhaity, Azmi
Che Nur Mazadillina, Che Zahari
J. A. Ichwan, Solachuddin
author_sort Nurul Haida, Idrus
title Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines
title_short Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines
title_full Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines
title_fullStr Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines
title_full_unstemmed Cytotoxic and anti- inflammatory activities of glycosaminoglycans (GAGs) from selected sea food waste extract on cell lines
title_sort cytotoxic and anti- inflammatory activities of glycosaminoglycans (gags) from selected sea food waste extract on cell lines
publisher Trans Tech Publications Ltd
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/25474/1/Nurul%20Haida%20-%20SISTEC%202019%20-15%20July%202019.doc
http://umpir.ump.edu.my/id/eprint/25474/3/15.1%20Cytotoxic%20and%20anti-%20inflammatory%20activities%20of%20glycosaminoglycans%20%28GAGs%29.pdf
http://umpir.ump.edu.my/id/eprint/25474/
https://doi.org/10.4028/www.scientific.net/MSF.981.258
_version_ 1768006843516321792
score 13.211869

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