Cover Image

Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction

A reverse micellar was modified by combining the anionic AOT and zwitterionic lauryl sulfobetaine surfactant for the extraction of erythromycin was proposed for the first time as a new approach for antibiotic extraction. The stability of the mixed reverse micelle was evaluated in terms of the critic...

Full description

Saved in:
Bibliographic Details
Main Authors: Siti Norazimah, Mohamad-Aziz, Zularisam, A. W., Mimi Sakinah, A. M.
Format: Article
Language:English
Published: Elsevier 2019
Subjects:
Q Science (General)
QD Chemistry
T Technology (General)
Online Access:http://umpir.ump.edu.my/id/eprint/25164/1/journal%20accepted%203.pdf
http://umpir.ump.edu.my/id/eprint/25164/
http://doi.org/10.1016/j.seppur.2019.115816
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.ump.umpir.25164
record_format eprints
spelling my.ump.umpir.251642019-10-24T08:31:31Z http://umpir.ump.edu.my/id/eprint/25164/ Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction Siti Norazimah, Mohamad-Aziz Zularisam, A. W. Mimi Sakinah, A. M. Q Science (General) QD Chemistry T Technology (General) A reverse micellar was modified by combining the anionic AOT and zwitterionic lauryl sulfobetaine surfactant for the extraction of erythromycin was proposed for the first time as a new approach for antibiotic extraction. The stability of the mixed reverse micelle was evaluated in terms of the critical micelle concentration (CMC) using the Wilhelmy Ring method, as well as the thermodynamic properties prior to extraction. The effect of parameters such as AOT concentration, lauryl sulfobetaine fraction and pH of the aqueous phase was investigated during forward extraction. Isopropanol volume percent (%), NaCl concentration, and pH of aqueous phase were investigated during backward extraction. The thermodynamic analysis confirmed the stability of the mixed AOT/lauryl sulfobetaine reverse micelle with a positive synergistic effect. The surface activity was enhanced, by which the CMC of the mixed reverse micelle was significantly lowered, ranging from 0.7 to 5.7 g/L. The overall thermodynamic data comprising ΔGm (between -15.44 to -20.24 kJ/mol), ΔGads (between -27.03 to -28.97 kJ/mol), and ΔGo ex (range between -0.39 to 8.87 kJ/mol) are affirmative that micellization was spontaneous. Erythromycin was also found to be interfacially active at all tested condition. The highest erythromycin solubilisation (94.2%) was achieved, even with low AOT surfactant (60.0 g/L) which reflects the synergy between AOT and lauryl sulfobetaine. In addition, in the absence of isopropanol, erythromycin was found to be successfully recovered during the backward extraction. However, isopropanol is still considered as a recovery booster which enables higher erythromycin recovery. Elsevier 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/25164/1/journal%20accepted%203.pdf Siti Norazimah, Mohamad-Aziz and Zularisam, A. W. and Mimi Sakinah, A. M. (2019) Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction. Separation and Purification Technology, 229. pp. 1-42. ISSN 1383-5866 http://doi.org/10.1016/j.seppur.2019.115816 doi: https://doi.org/10.1016/j.seppur.2019.115816
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic Q Science (General)
QD Chemistry
T Technology (General)
spellingShingle Q Science (General)
QD Chemistry
T Technology (General)
Siti Norazimah, Mohamad-Aziz
Zularisam, A. W.
Mimi Sakinah, A. M.
Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
description A reverse micellar was modified by combining the anionic AOT and zwitterionic lauryl sulfobetaine surfactant for the extraction of erythromycin was proposed for the first time as a new approach for antibiotic extraction. The stability of the mixed reverse micelle was evaluated in terms of the critical micelle concentration (CMC) using the Wilhelmy Ring method, as well as the thermodynamic properties prior to extraction. The effect of parameters such as AOT concentration, lauryl sulfobetaine fraction and pH of the aqueous phase was investigated during forward extraction. Isopropanol volume percent (%), NaCl concentration, and pH of aqueous phase were investigated during backward extraction. The thermodynamic analysis confirmed the stability of the mixed AOT/lauryl sulfobetaine reverse micelle with a positive synergistic effect. The surface activity was enhanced, by which the CMC of the mixed reverse micelle was significantly lowered, ranging from 0.7 to 5.7 g/L. The overall thermodynamic data comprising ΔGm (between -15.44 to -20.24 kJ/mol), ΔGads (between -27.03 to -28.97 kJ/mol), and ΔGo ex (range between -0.39 to 8.87 kJ/mol) are affirmative that micellization was spontaneous. Erythromycin was also found to be interfacially active at all tested condition. The highest erythromycin solubilisation (94.2%) was achieved, even with low AOT surfactant (60.0 g/L) which reflects the synergy between AOT and lauryl sulfobetaine. In addition, in the absence of isopropanol, erythromycin was found to be successfully recovered during the backward extraction. However, isopropanol is still considered as a recovery booster which enables higher erythromycin recovery.
format Article
author Siti Norazimah, Mohamad-Aziz
Zularisam, A. W.
Mimi Sakinah, A. M.
author_facet Siti Norazimah, Mohamad-Aziz
Zularisam, A. W.
Mimi Sakinah, A. M.
author_sort Siti Norazimah, Mohamad-Aziz
title Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_short Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_full Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_fullStr Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_full_unstemmed Reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
title_sort reverse micellar modified mixed anionic and zwitterionic surfactant system for antibiotic extraction
publisher Elsevier
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/25164/1/journal%20accepted%203.pdf
http://umpir.ump.edu.my/id/eprint/25164/
http://doi.org/10.1016/j.seppur.2019.115816
_version_ 1648741189078220800
score 13.211869

Similar Items