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Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability

This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactant...

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Main Authors: Rashid, Muhammad Abid, Naza, Tehreem, Abbas, Madeeha, Nazir, Sadia, Younas, Nafisa, Majeed, Sana, Qureshi, Naseem, Akhtar, Muhammad Nadeem
Format: Article
Language:English
Published: Elsevier 2019
Subjects:
QR Microbiology
Online Access:http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf
http://umpir.ump.edu.my/id/eprint/23931/
https://doi.org/10.1016/j.colcom.2018.11.006
https://doi.org/10.1016/j.colcom.2018.11.006
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spelling my.ump.umpir.239312019-01-23T08:21:16Z http://umpir.ump.edu.my/id/eprint/23931/ Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem QR Microbiology This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactants tween 20/60, 1-propanol and phosphate buffer. The optimum weight ratios of components and MEs areas were determined by pseudo-ternary phase diagram. All formulations were physically characterized by centrifugation, pH, refractive index, conductivity, viscosity, surface tension and partition coefficient. The specific residence site of chloramphenicol was detected by 1H NMR study. It was uncovered that drug is entrapped between the oxyethylene groups of hydrophilic shell of MEs. So, the drug was screened from bulk water and its stability was enhanced. Thus, all characterizations have suggested that formulated MEs have potential for ocular application, being able to use as efficient drug carrier for ocular drug delivery. Elsevier 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf Rashid, Muhammad Abid and Naza, Tehreem and Abbas, Madeeha and Nazir, Sadia and Younas, Nafisa and Majeed, Sana and Qureshi, Naseem and Akhtar, Muhammad Nadeem (2019) Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability. Colloid and Interface Science Communications, 28. pp. 41-48. ISSN 2215-0382 https://doi.org/10.1016/j.colcom.2018.11.006 https://doi.org/10.1016/j.colcom.2018.11.006
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QR Microbiology
spellingShingle QR Microbiology
Rashid, Muhammad Abid
Naza, Tehreem
Abbas, Madeeha
Nazir, Sadia
Younas, Nafisa
Majeed, Sana
Qureshi, Naseem
Akhtar, Muhammad Nadeem
Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
description This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactants tween 20/60, 1-propanol and phosphate buffer. The optimum weight ratios of components and MEs areas were determined by pseudo-ternary phase diagram. All formulations were physically characterized by centrifugation, pH, refractive index, conductivity, viscosity, surface tension and partition coefficient. The specific residence site of chloramphenicol was detected by 1H NMR study. It was uncovered that drug is entrapped between the oxyethylene groups of hydrophilic shell of MEs. So, the drug was screened from bulk water and its stability was enhanced. Thus, all characterizations have suggested that formulated MEs have potential for ocular application, being able to use as efficient drug carrier for ocular drug delivery.
format Article
author Rashid, Muhammad Abid
Naza, Tehreem
Abbas, Madeeha
Nazir, Sadia
Younas, Nafisa
Majeed, Sana
Qureshi, Naseem
Akhtar, Muhammad Nadeem
author_facet Rashid, Muhammad Abid
Naza, Tehreem
Abbas, Madeeha
Nazir, Sadia
Younas, Nafisa
Majeed, Sana
Qureshi, Naseem
Akhtar, Muhammad Nadeem
author_sort Rashid, Muhammad Abid
title Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_short Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_full Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_fullStr Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_full_unstemmed Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_sort chloramphenicol loaded microemulsions: development, characterization and stability
publisher Elsevier
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf
http://umpir.ump.edu.my/id/eprint/23931/
https://doi.org/10.1016/j.colcom.2018.11.006
https://doi.org/10.1016/j.colcom.2018.11.006
_version_ 1643669724959080448
score 13.211869

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