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Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin

In this work, the direct electrochemistry of hemoglobin (Hb), which was immobilized on carbonyl functionalized single walled carbon nanotube (SWCNT) and deposited onto a gold (Au) electrode has been described. The synthesis of the network of crosslinked SWCNT /Hb was done with the help of crosslinki...

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Main Authors: A. K. M., Kafi, C. C. L., Yam, Nina Suhaity, Azmi, Mashitah, Mohd Yusoff
Format: Article
Language:English
Published: American Scientific Publishers 2018
Subjects:
QD Chemistry
Online Access:http://umpir.ump.edu.my/id/eprint/15618/1/Carbonyl%20Functionalized%20Single%20Walled%20Carbon%20Nanotube-Hb%20Crosslinked%20Network1.pdf
http://umpir.ump.edu.my/id/eprint/15618/
https://doi.org/10.1166/jnn.2018.14327
https://doi.org/10.1166/jnn.2018.14327
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spelling my.ump.umpir.156182023-04-03T00:48:22Z http://umpir.ump.edu.my/id/eprint/15618/ Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin A. K. M., Kafi C. C. L., Yam Nina Suhaity, Azmi Mashitah, Mohd Yusoff QD Chemistry In this work, the direct electrochemistry of hemoglobin (Hb), which was immobilized on carbonyl functionalized single walled carbon nanotube (SWCNT) and deposited onto a gold (Au) electrode has been described. The synthesis of the network of crosslinked SWCNT /Hb was done with the help of crosslinking agent EDC (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide). The UV–Vis and FTIR spectroscopy of SWCNT/Hb networks showed that Hb maintained its natural structure and kept good stability. In addition with this, scanning electron microscopy (SEM) illustrated that SWCNT/Hb networks had a featured layered structure and Hb being strongly liked with SWCNT surface. Cyclic voltammetry (CV) was used to study and to optimize the performance of the resulting modified electrode. The cyclic voltammetric (CV) responses of SWCNT/Hb networks in pH 7.0 exhibit prominent redox couple for the FeIII/II redox process with a midpoint potential of -0.46 V and -0.34, cathodic and anodic respectively. Furthermore, SWCNT/Hb networks are utilized for the detection of hydrogen peroxide (H2O2). Electrochemical measurements reveal that the resulting SWCNT/Hb electrodes display high electrocatalytic activity to H2O2 with high sensitivity, wide linear range, and low detection limit. Overall, the electrochemical results are due to excellent biocompatibility and excellent electron transport efficiency of CNT as well as high Hb loading and synergistic catalytic effect of the modified electrode toward H2O2. American Scientific Publishers 2018 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/15618/1/Carbonyl%20Functionalized%20Single%20Walled%20Carbon%20Nanotube-Hb%20Crosslinked%20Network1.pdf A. K. M., Kafi and C. C. L., Yam and Nina Suhaity, Azmi and Mashitah, Mohd Yusoff (2018) Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin. Journal of Nanoscience and Nanotechnology, 18 (4). pp. 2422-2428. ISSN 1533-4880 (Print); 1533-4899 (Online) https://doi.org/10.1166/jnn.2018.14327 https://doi.org/10.1166/jnn.2018.14327
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
A. K. M., Kafi
C. C. L., Yam
Nina Suhaity, Azmi
Mashitah, Mohd Yusoff
Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin
description In this work, the direct electrochemistry of hemoglobin (Hb), which was immobilized on carbonyl functionalized single walled carbon nanotube (SWCNT) and deposited onto a gold (Au) electrode has been described. The synthesis of the network of crosslinked SWCNT /Hb was done with the help of crosslinking agent EDC (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide). The UV–Vis and FTIR spectroscopy of SWCNT/Hb networks showed that Hb maintained its natural structure and kept good stability. In addition with this, scanning electron microscopy (SEM) illustrated that SWCNT/Hb networks had a featured layered structure and Hb being strongly liked with SWCNT surface. Cyclic voltammetry (CV) was used to study and to optimize the performance of the resulting modified electrode. The cyclic voltammetric (CV) responses of SWCNT/Hb networks in pH 7.0 exhibit prominent redox couple for the FeIII/II redox process with a midpoint potential of -0.46 V and -0.34, cathodic and anodic respectively. Furthermore, SWCNT/Hb networks are utilized for the detection of hydrogen peroxide (H2O2). Electrochemical measurements reveal that the resulting SWCNT/Hb electrodes display high electrocatalytic activity to H2O2 with high sensitivity, wide linear range, and low detection limit. Overall, the electrochemical results are due to excellent biocompatibility and excellent electron transport efficiency of CNT as well as high Hb loading and synergistic catalytic effect of the modified electrode toward H2O2.
format Article
author A. K. M., Kafi
C. C. L., Yam
Nina Suhaity, Azmi
Mashitah, Mohd Yusoff
author_facet A. K. M., Kafi
C. C. L., Yam
Nina Suhaity, Azmi
Mashitah, Mohd Yusoff
author_sort A. K. M., Kafi
title Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin
title_short Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin
title_full Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin
title_fullStr Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin
title_full_unstemmed Carbonyl functionalized single walled carbon nanotube-hb crosslinked network : A novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin
title_sort carbonyl functionalized single walled carbon nanotube-hb crosslinked network : a novel platform for studying bio-electrochemistry and electrocatalysis of hemoglobin
publisher American Scientific Publishers
publishDate 2018
url http://umpir.ump.edu.my/id/eprint/15618/1/Carbonyl%20Functionalized%20Single%20Walled%20Carbon%20Nanotube-Hb%20Crosslinked%20Network1.pdf
http://umpir.ump.edu.my/id/eprint/15618/
https://doi.org/10.1166/jnn.2018.14327
https://doi.org/10.1166/jnn.2018.14327
_version_ 1762392383700336640
score 13.211869

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