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Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro

Despite progressive research being done on drug therapy to treat breast cancer, the number of patients succumbing to the disease is still a major issue. Combinatorial treatment using different drugs and herbs to treat cancer patients is of major interest in scientists nowadays. Doxorubicin is one of...

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Main Authors: Muhammad Yusran, Abdul Aziz, Nadiah, Abu, Yeap, Swee Keong, Ho, Wan Yong, Abdul Rahman, Omar, Nor Hadiani, Ismail, Syahida, Ahmad, Pirozyan, Mehdi R., Akhtar, Muhammad Nadeem, Noorjahan Banu, Alitheen
Format: Article
Language:English
Published: MDPI - Open Access Publishing 2016
Subjects:
Q Science (General)
Online Access:http://umpir.ump.edu.my/id/eprint/14412/1/Combinatorial%20Cytotoxic%20Effects%20of%20Damnacanthal%20and%20Doxorubicin%20against%20Human%20Breast%20Cancer%20MCF-7%20Cells%20in%20Vitro.pdf
http://umpir.ump.edu.my/id/eprint/14412/
http://www.mdpi.com/1420-3049/21/9/1228
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spelling my.ump.umpir.144122018-04-19T01:06:32Z http://umpir.ump.edu.my/id/eprint/14412/ Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro Muhammad Yusran, Abdul Aziz Nadiah, Abu Yeap, Swee Keong Ho, Wan Yong Abdul Rahman, Omar Nor Hadiani, Ismail Syahida, Ahmad Pirozyan, Mehdi R. Akhtar, Muhammad Nadeem Noorjahan Banu, Alitheen Q Science (General) Despite progressive research being done on drug therapy to treat breast cancer, the number of patients succumbing to the disease is still a major issue. Combinatorial treatment using different drugs and herbs to treat cancer patients is of major interest in scientists nowadays. Doxorubicin is one of the most used drugs to treat breast cancer patients. The combination of doxorubicin to other drugs such as tamoxifen has been reported. Nevertheless, the combination of doxorubicin with a natural product-derived agent has not been studied yet. Morinda citrifolia has always been sought out for its remarkable remedies. Damnacanthal, an anthraquinone that can be extracted from the roots of Morinda citrifolia is a promising compound that possesses a variety of biological properties. This study aimed to study the therapeutic effects of damnacanthal in combination with doxorubicin in breast cancer cells. Collectively, the combination of both these molecules enhanced the efficacy of induced cell death in MCF-7 as evidenced by the MTT assay, cell cycle, annexin V and expression of apoptosis-related genes and proteins. The effectiveness of doxorubicin as an anti-cancer drug was increased upon addition of damnacanthal. These results could provide a promising approach to treat breast cancer patients. MDPI - Open Access Publishing 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/14412/1/Combinatorial%20Cytotoxic%20Effects%20of%20Damnacanthal%20and%20Doxorubicin%20against%20Human%20Breast%20Cancer%20MCF-7%20Cells%20in%20Vitro.pdf Muhammad Yusran, Abdul Aziz and Nadiah, Abu and Yeap, Swee Keong and Ho, Wan Yong and Abdul Rahman, Omar and Nor Hadiani, Ismail and Syahida, Ahmad and Pirozyan, Mehdi R. and Akhtar, Muhammad Nadeem and Noorjahan Banu, Alitheen (2016) Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro. Molecules, 21 (9). pp. 1-15. ISSN 1420-3049 (print); 1420-3049 (online) http://www.mdpi.com/1420-3049/21/9/1228 DOI: 10.3390/molecules21091228
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Muhammad Yusran, Abdul Aziz
Nadiah, Abu
Yeap, Swee Keong
Ho, Wan Yong
Abdul Rahman, Omar
Nor Hadiani, Ismail
Syahida, Ahmad
Pirozyan, Mehdi R.
Akhtar, Muhammad Nadeem
Noorjahan Banu, Alitheen
Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro
description Despite progressive research being done on drug therapy to treat breast cancer, the number of patients succumbing to the disease is still a major issue. Combinatorial treatment using different drugs and herbs to treat cancer patients is of major interest in scientists nowadays. Doxorubicin is one of the most used drugs to treat breast cancer patients. The combination of doxorubicin to other drugs such as tamoxifen has been reported. Nevertheless, the combination of doxorubicin with a natural product-derived agent has not been studied yet. Morinda citrifolia has always been sought out for its remarkable remedies. Damnacanthal, an anthraquinone that can be extracted from the roots of Morinda citrifolia is a promising compound that possesses a variety of biological properties. This study aimed to study the therapeutic effects of damnacanthal in combination with doxorubicin in breast cancer cells. Collectively, the combination of both these molecules enhanced the efficacy of induced cell death in MCF-7 as evidenced by the MTT assay, cell cycle, annexin V and expression of apoptosis-related genes and proteins. The effectiveness of doxorubicin as an anti-cancer drug was increased upon addition of damnacanthal. These results could provide a promising approach to treat breast cancer patients.
format Article
author Muhammad Yusran, Abdul Aziz
Nadiah, Abu
Yeap, Swee Keong
Ho, Wan Yong
Abdul Rahman, Omar
Nor Hadiani, Ismail
Syahida, Ahmad
Pirozyan, Mehdi R.
Akhtar, Muhammad Nadeem
Noorjahan Banu, Alitheen
author_facet Muhammad Yusran, Abdul Aziz
Nadiah, Abu
Yeap, Swee Keong
Ho, Wan Yong
Abdul Rahman, Omar
Nor Hadiani, Ismail
Syahida, Ahmad
Pirozyan, Mehdi R.
Akhtar, Muhammad Nadeem
Noorjahan Banu, Alitheen
author_sort Muhammad Yusran, Abdul Aziz
title Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro
title_short Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro
title_full Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro
title_fullStr Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro
title_full_unstemmed Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro
title_sort combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer mcf-7 cells in vitro
publisher MDPI - Open Access Publishing
publishDate 2016
url http://umpir.ump.edu.my/id/eprint/14412/1/Combinatorial%20Cytotoxic%20Effects%20of%20Damnacanthal%20and%20Doxorubicin%20against%20Human%20Breast%20Cancer%20MCF-7%20Cells%20in%20Vitro.pdf
http://umpir.ump.edu.my/id/eprint/14412/
http://www.mdpi.com/1420-3049/21/9/1228
_version_ 1643667425240023040
score 13.211869

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