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A Review on Metabolic Pathway Analysis in Biological Production

Metabolic pathway analysis has become significant for evaluating intrinsic network characteristics in biochemical reaction network reconstruction. Current applications of metabolic pathway analysis involve identifying the enzyme for the desired production, identifying pathways of optimal production...

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Main Authors: Lim, Sim Yi, Tan, Li Chin, Mohd Saberi, Mohamad, Safaai, Deris, Saad, Subair, Zuwairie, Ibrahim
Format: Article
Language:English
Published: Bentham Science Publishers 2015
Subjects:
QD Chemistry
Online Access:http://umpir.ump.edu.my/id/eprint/12809/1/fkee-2015-zuwairie-A%20Review%20on%20Metabolic%20Pathway.pdf
http://umpir.ump.edu.my/id/eprint/12809/
http://www.eurekaselect.com/137955/article#
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spelling my.ump.umpir.128092018-02-08T02:35:01Z http://umpir.ump.edu.my/id/eprint/12809/ A Review on Metabolic Pathway Analysis in Biological Production Lim, Sim Yi Tan, Li Chin Mohd Saberi, Mohamad Safaai, Deris Saad, Subair Zuwairie, Ibrahim QD Chemistry Metabolic pathway analysis has become significant for evaluating intrinsic network characteristics in biochemical reaction network reconstruction. Current applications of metabolic pathway analysis involve identifying the enzyme for the desired production, identifying pathways of optimal production, determining non-redundant pathways for drug design, and genome comparisons by alignment of pathways for missing genes identification. With the expanded application of bioinformatics, more organized methods have been intro- duced to examine the overall metabolic networks and network reconstruction based on genomic data. There are several in silico approaches for analysing metabolic pathways, including elementary mode analysis and extreme pathway under pathway topology analysis, flux balance analysis and metabolic flux analysis under analysis of metabolic fluxes, and metabolic control analysis. In this paper, elementary mode analysis, flux balance analysis, metabolic flux analysis and metabolic control analysis are reviewed, together with their application in metabolic network reconstruction and biologi- cal production enhancement in biological organisms. Next, a comparison of strengths and weaknesses between each of the metabolic pathway analysis methods is presented in this paper. Bentham Science Publishers 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/12809/1/fkee-2015-zuwairie-A%20Review%20on%20Metabolic%20Pathway.pdf Lim, Sim Yi and Tan, Li Chin and Mohd Saberi, Mohamad and Safaai, Deris and Saad, Subair and Zuwairie, Ibrahim (2015) A Review on Metabolic Pathway Analysis in Biological Production. Mini-Reviews in Organic Chemistry, 13 (6). pp. 506-523. ISSN 1570-193X (print); 1875-6298 (online) http://www.eurekaselect.com/137955/article# DOI: 10.2174/1570193X13666151218191358
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Lim, Sim Yi
Tan, Li Chin
Mohd Saberi, Mohamad
Safaai, Deris
Saad, Subair
Zuwairie, Ibrahim
A Review on Metabolic Pathway Analysis in Biological Production
description Metabolic pathway analysis has become significant for evaluating intrinsic network characteristics in biochemical reaction network reconstruction. Current applications of metabolic pathway analysis involve identifying the enzyme for the desired production, identifying pathways of optimal production, determining non-redundant pathways for drug design, and genome comparisons by alignment of pathways for missing genes identification. With the expanded application of bioinformatics, more organized methods have been intro- duced to examine the overall metabolic networks and network reconstruction based on genomic data. There are several in silico approaches for analysing metabolic pathways, including elementary mode analysis and extreme pathway under pathway topology analysis, flux balance analysis and metabolic flux analysis under analysis of metabolic fluxes, and metabolic control analysis. In this paper, elementary mode analysis, flux balance analysis, metabolic flux analysis and metabolic control analysis are reviewed, together with their application in metabolic network reconstruction and biologi- cal production enhancement in biological organisms. Next, a comparison of strengths and weaknesses between each of the metabolic pathway analysis methods is presented in this paper.
format Article
author Lim, Sim Yi
Tan, Li Chin
Mohd Saberi, Mohamad
Safaai, Deris
Saad, Subair
Zuwairie, Ibrahim
author_facet Lim, Sim Yi
Tan, Li Chin
Mohd Saberi, Mohamad
Safaai, Deris
Saad, Subair
Zuwairie, Ibrahim
author_sort Lim, Sim Yi
title A Review on Metabolic Pathway Analysis in Biological Production
title_short A Review on Metabolic Pathway Analysis in Biological Production
title_full A Review on Metabolic Pathway Analysis in Biological Production
title_fullStr A Review on Metabolic Pathway Analysis in Biological Production
title_full_unstemmed A Review on Metabolic Pathway Analysis in Biological Production
title_sort review on metabolic pathway analysis in biological production
publisher Bentham Science Publishers
publishDate 2015
url http://umpir.ump.edu.my/id/eprint/12809/1/fkee-2015-zuwairie-A%20Review%20on%20Metabolic%20Pathway.pdf
http://umpir.ump.edu.my/id/eprint/12809/
http://www.eurekaselect.com/137955/article#
_version_ 1643666995633192960
score 13.211869

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